The synthesis of sulforaphane analogues and their protection effect against cisplatin induced cytotoxicity in kidney cells was written by Kim, Taejung;Kim, Young-Joo;Han, Im-Ho;Lee, Dahae;Ham, Jungyeob;Kang, Ki Sung;Lee, Jae Wook. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Quality Control of 4-Fluorobenzylisothiocyanate This article mentions the following:
A series of sulforaphane analogs e.g., I were synthesized with various amines by treatment of carbon disulfide followed by Boc2O and DMAP. These synthesized sulforaphane analogs were tested on cisplatin treated cultured LLC-PK1 kidney cell line. Among these analogs, several compounds including I show a potent effect on kidney cell protection assay at the concentration of 2.5 μM. Further studies with compound I revealed that the kidney cell protection effect was related by inhibiting the apoptosis pathway through JNK-p53-caspase apoptotic cascade. Compound I may be considered as a promising candidate for the development of new kidney protective agent against drug induced acute kidney disease. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzylisothiocyanate (cas: 2740-88-7Quality Control of 4-Fluorobenzylisothiocyanate).
4-Fluorobenzylisothiocyanate (cas: 2740-88-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of 4-Fluorobenzylisothiocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics