Quinazoline antifolates inhibiting thymidylate synthase. Variation of the amino acid was written by Jones, Terence R.;Smithers, Michael J.;Betteridge, Richard F.;Taylor, Michael A.;Jackman, Ann L.;Calvert, A. Hilary;Davies, Lawrence C.;Harrap, Kenneth R.. And the article was included in Journal of Medicinal Chemistry in 1986.Recommanded Product: Methyl 4-(4-aminophenyl)butanoate This article mentions the following:
Amino acid analogs I (X = Asp, Ala, Gly; R = H) (II) of N10-propargyl-5,8-dideazafolic acid (I; X = Glu, R = H) (III) were prepared by treating p-H2NC6H4CO-X-OR [X = Asp(OEt), Ala, R = Et; X = Gly, R = Me] with HCCCH2Br, treating the resulting benzoyl amino acid esters IV (X, R = same) with quinazoline V, and saponifying the resulting I [X = Asp(OEt), Ala, R = Et; X = Gly, R = Me]. Analogs VI (n = 0, 3) were also prepared II and VI inhibited thymidine synthase with less potency than III, and none of the above analogs improved upon III in inhibiting the growth of 4210 cells in culture. In the experiment, the researchers used many compounds, for example, Methyl 4-(4-aminophenyl)butanoate (cas: 20637-09-6Recommanded Product: Methyl 4-(4-aminophenyl)butanoate).
Methyl 4-(4-aminophenyl)butanoate (cas: 20637-09-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: Methyl 4-(4-aminophenyl)butanoate
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