Synthesis of chiral β-amino acid derivatives by asymmetric hydrosilylation with an imidazole derived organocatalyst was written by Jones, Simon;Li, Xianfu. And the article was included in Tetrahedron in 2012.Name: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:
The organocatalyzed-asym. hydrosilylation of a number of N-aryl and -alkyl β-substituted enamino esters proceeds in generally good yield and enantioselectivity. Crucial to obtaining high yield and selectivity was the addition of benzoic acid as an additive and under these conditions, both N-aryl and -alkyl substituents were well tolerated. β-Aryl and -alkyl substituents were evaluated and a model proposed to account for the exptl. observations based upon enamine tautomerization and conformational preferences of the reactive ketimine intermediate. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Name: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).
Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics