Thienopyridine urea inhibitors of KDR kinase was written by Heyman, H. Robin;Frey, Robin R.;Bousquet, Peter F.;Cunha, George A.;Moskey, Maria D.;Ahmed, Asma A.;Soni, Niru B.;Marcotte, Patrick A.;Pease, Lori J.;Glaser, Keith B.;Yates, Melinda;Bouska, Jennifer J.;Albert, Daniel H.;Black-Schaefer, Candace L.;Dandliker, Peter J.;Stewart, Kent D.;Rafferty, Paul;Davidsen, Steven K.;Michaelides, Michael R.;Curtin, Michael L.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Application of 16413-26-6 This article mentions the following:
A series of substituted thienopyridine ureas was prepared and evaluated for enzymic and cellular inhibition of KDR kinase activity. Several of these analogs, such as I, are potent inhibitors of KDR (<10 nM) in both enzymic and cellular assays. Further characterization of inhibitor I indicated that this analog possessed excellent in vivo potency (ED50 2.1 mg/kg) as measured in an estradiol-induced mouse uterine edema model. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Application of 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 16413-26-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics