A ring-closing metathesis approach for the synthesis of (±)-pregabalin was written by Bobade, Vivek D.;Mhaske, Pravin C.;Vadgaonkar, Kamlesh S.;Shelke, Shivaji H.. And the article was included in Monatshefte fuer Chemie in 2012.Product Details of 10203-58-4 This article mentions the following:
Efficient utilization of a Mannich-type reaction and the ring-closing metathesis (RCM) approach that leads to a convenient synthesis of 3-(aminomethyl)-5-methylhexanoic acid (pregabalin) is described. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Product Details of 10203-58-4).
Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 10203-58-4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics