A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor was written by Bach, Peter;Bostroem, Jonas;Brickmann, Kay;van Giezen, J. J. J.;Hovland, Ragnar;Petersson, Annika U.;Ray, Asim;Zetterberg, Fredrik. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Quality Control of 3-Cyanophenylisocyanate This article mentions the following:
A novel series of P2Y12 antagonists for development of drugs within the antiplatelet area is presented. The synthesis of 2-(4-carbamoylpiperazinyl)pyridine-5-carboxylates and their structure-activity relationships (SAR) are described. Several compounds showed P2Y12 antagonistic activities in the sub-micromolar range. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Quality Control of 3-Cyanophenylisocyanate).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Quality Control of 3-Cyanophenylisocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics