Synthesis of adamantane derivatives with potential antiviral activity was written by Arya, V. P.;Fernandes, F.;Ghate, S. P.;Costa-Pereira, F. X. R.;Wasaiwalla, Y. H.. And the article was included in Indian Journal of Chemistry in 1972.Electric Literature of C8H6FNS This article mentions the following:
Adamantane derivatives (I; R = e.g., NHEt, NHSO2NMe2, NHCH2(NH2)C:NOH, NHCSNHR1, R1 = e.g., allyl, CMe3, CH2C6H4F-p; CONH(CH2)3R2, R2 = e.g., piperidino, morpholino, 4-methyl-1-piperazinyl) were prepared by treating I (R = NH2) with isothiocyanates, isocyanates and Me2NSO2NHCl. Some 1-(alkylamino)adamantanes and substituted adamantane-1-carboxamides were also prepared Antiviral activity of these compounds against influenza PR3 virus was described. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzylisothiocyanate (cas: 2740-88-7Electric Literature of C8H6FNS).
4-Fluorobenzylisothiocyanate (cas: 2740-88-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Electric Literature of C8H6FNS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics