Assembly of Divalent Ligands and Their Effect on Divalent Binding to Pseudomonas aeruginosa Lectin LecA was written by Yu, Guangyun;Vicini, Anna Chiara;Pieters, Roland J.. And the article was included in Journal of Organic Chemistry in 2019.Name: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate This article mentions the following:
Divalent ligands were prepared as inhibitors for the adhesion protein of the problematic Pseudomonas aeruginosa pathogen. Bridging two binding sites enables simultaneous binding of two galactose moieties which strongly enhances binding. An alternating motif of glucose and triazole and aryl groups was shown to have the right mix of rigidity, solubility and ease of synthesis. Spacers were varied with respect to the core unit as well as the aglycon portions, to optimize dynamics and enhance interactions with the protein. Affinities of the divalent ligands were measured by ITC and Kd’s as low as 12 nM were determined, notably for a com-pounds with either a rigid (phenyl) or flexible (butyl) unit at the core. Introducing a Ph aglycon moiety next to the galactoside ligands on both termini did indeed lead to a higher enthalpy of binding which was more than compensated by entropic costs. The results were discussed in terms of thermodn. and theor. calculations of the expected and observed multivalency effects. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Name: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate).
(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate
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Ester – an overview | ScienceDirect Topics