Base initiated aromatization/C-O bond formation: a new entry to O-pyrazole polyfluoroarylated ethers was written by Tang, Xiangyang;Chang, Jing;Liu, Cuibo;Zhang, Bin. And the article was included in Tetrahedron Letters in 2014.Computed Properties of C12H14O3 This article mentions the following:
A base initiated intermol. SNAr reaction of pyrazolones with polyfluoroarenes was developed. The process involved the isomerization aromatization of pyrazolone followed by the C-O bond formation via the selective C-F bond cleavage. With this strategy, a wide range of O-pyrazole polyfluoroarylated ethers bearing diverse functional groups were synthesized in mild to good yields. Addnl., our method was also applied to the isoxazole substrates. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Computed Properties of C12H14O3).
Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C12H14O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics