Design, synthesis and evaluation of antimycotic and fungicidal activities of novel substituted 1-[(2-benzyl-1,3-dioxolan-4-yl)methyl]-1H-imidazoles was written by Talismanov, V. S.;Popkov, S. V.;Zykova, S. S.;Karmanova, O. G.;Tsaplin, G. V.. And the article was included in Journal of Pharmaceutical Sciences and Research in 2018.Product Details of 587-88-2 This article mentions the following:
In vitro tests of substituted 1-(1,3-dioxolan-4-ylmethyl)-1H-imidazoles I (R1 = H, 4-Cl; R2 = C6H5, 4-FC6H4, 1-naphthyl, etc.) showed high antimycotic activity against pathogens of C. albicans and S. salmonicolor, as well as opportunistic pathogens of F. oxysporum and F. moniliforme. The target compounds were derived by cyclization of substituted ketones with 3-chloro-1,2-propanediol followed by alkylation of the derived 4-chloromethyl-1,3-dioxolanes of sodium salts of imidazole. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Product Details of 587-88-2).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 587-88-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics