Metabolism-Guided Design of Short-Acting Calcium-Sensing Receptor Antagonists was written by Southers, James A.;Bauman, Jonathan N.;Price, David A.;Humphries, Paul S.;Balan, Gayatri;Sagal, John F.;Maurer, Tristan S.;Zhang, Yan;Oliver, Robert;Herr, Michael;Healy, David R.;Li, Mei;Kapinos, Brendon;Fate, Gwendolyn D.;Riccardi, Keith A.;Paralkar, Vishwas M.;Brown, Thomas A.;Kalgutkar, Amit S.. And the article was included in ACS Medicinal Chemistry Letters in 2010.COA of Formula: C15H21BO4 This article mentions the following:
As part of a strategy to deliver short-acting calcium-sensing receptor (CaSR) antagonists, the metabolically labile thiomethyl functionality was incorporated into the zwitterionic amino alc. derivative I with the hope of increasing human clearance through oxidative metabolism, while delivering a pharmacol. inactive sulfoxide metabolite. The effort led to the identification of thioanisoles II (R = H, F) as potent and orally active CaSR antagonists with a rapid onset of action and short pharmacokinetic half-lives, which led to a rapid and transient stimulation of parathyroid hormone in a dose-dependent fashion following oral administration to rats. On the basis of the balance between target pharmacol., safety, and human disposition profiles, compounds II were advanced as clin. candidates for the treatment of osteoporosis. In the experiment, the researchers used many compounds, for example, Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6COA of Formula: C15H21BO4).
Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C15H21BO4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics