Evaluation of stereochemically dense morpholine-based scaffolds as proline surrogates in β-turn peptides was written by Sladojevich, Filippo;Guarna, Antonio;Trabocchi, Andrea. And the article was included in Organic & Biomolecular Chemistry in 2010.Product Details of 133467-01-3 This article mentions the following:
Four peptides differing for the structure of the new morpholine-based heterocyclic compound acting as a turn inducer were synthesized in solution phase, and the conformational preferences were assessed by means of NMR anal. All spectroscopic data revealed an adaptive behavior of the turn peptides in generating turn conformations stabilized by intramol. hydrogen-bonds, despite the conformational changes of the turn inducer. Thus, this study suggests the possibility of functionalizing morpholine-containing β-turn peptides with no significant loss of the secondary framework. The 3,4-dihydro-2H-[1,4]oxazine-containing peptide showed a more compact structure stabilized by an addnl. γ-turn-forming hydrogen-bond experienced by the Gly amide proton. In the experiment, the researchers used many compounds, for example, Boc-D-Leu-OMe (cas: 133467-01-3Product Details of 133467-01-3).
Boc-D-Leu-OMe (cas: 133467-01-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 133467-01-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics