Synthesis and biological activities of bradykinin analogs with Ψ(E,CH:CH) and Ψ(CH2NH) isosteric peptide bond replacements was written by Scarso, A.;Degelaen, J.;Viville, R.;De Cock, E.;Van Marsenille, M.;Van der Auwera, L.;Tourwe, D.;Van Binst, G.. And the article was included in Bulletin des Societes Chimiques Belges in 1991.Recommanded Product: 87694-53-9 This article mentions the following:
The synthesis of bradykinin analogs is described in which the Gly4-Phe5, Phe5-Ser6, or the Pro7-Phe8 peptide bond has been replaced by a trans carbon-carbon double bond or by a reduced peptide bond. Some of the analogs display high potency and prolonged activity in the rat blood pressure test, indicating increased metabolic stability. A clear selectivity is obtained towards the myotropic effect in the guinea pig ileum. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Recommanded Product: 87694-53-9).
(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 87694-53-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics