Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine was written by Robertson, David W.;Beedle, E. E.;Krushinski, Joseph H.;Pollock, G. Don;Wilson, Harve;Wyss, Virginia L.;Hayes, J. Scott. And the article was included in Journal of Medicinal Chemistry in 1985.Application In Synthesis of Methyl 4-Hydroxy-2-methoxybenzoate This article mentions the following:
The structural requirements for optimal inotropic activity in a series of phenylimidazopyridines were investigated. 2-Phenylimidazo[4,5-c]pyridines were generally 5-10-fold more potent than analogous 2-phenylimidazo[4,5-b]pyridines, or 8-phenylpurines. Furthermore, all the imidazo[4,5-c]pyridines were orally active; in contrast, only 1 of the imidazo[4,5-b]pyridine derivatives was significantly active orally. The structure-activity relationship of this series is presented and compared to that of the imidazo[4,5-b]pyridine and purine series. The phenylimidazopyridines (80 compounds) were prepared from o-pyridinediamines and substituted benzoic acids. In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Application In Synthesis of Methyl 4-Hydroxy-2-methoxybenzoate).
Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of Methyl 4-Hydroxy-2-methoxybenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics