Rh(III)-Catalyzed Domino [4 + 2] Annulation/Aza-Michael Addition of N-(Pivaloyloxy)benzamides with 1,5-Enynes via C-H Activation: Synthesis of Functionalized Aromathecins was written by Raji Reddy, Chada;Mallesh, Kathe;Bodasu, Srinivas;Donthiri, Ramachandra Reddy. And the article was included in Journal of Organic Chemistry in 2020.Category: esters-buliding-blocks This article mentions the following:
Reported herein is the Rh(III)-catalyzed cascade annulation reaction of N-(pivaloyloxy)benzamides with 1,5-enynes to access diversely substituted aromathecin derivatives, e.g., I (R = H, Br, Cl, NO2, Me, OMe), involving C-H activation. The developed procedure offers an efficient synthetic tool for the reaction of a wide range of N-(pivaloyloxy)benzamides and 1,5-enynes with good atom-economy and functional group tolerance. The key reactions involved in this annulation are alkyne insertion and aza-Michael addition under oxidant-free mild reaction conditions. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Category: esters-buliding-blocks).
Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics