Amphiphilic mPEG-block-poly (profen amide-co-esters) copolymers: One pot biocatalytic synthesis, self-assembly in water and drug release was written by Qian, Xueqi;Wu, Qi;Xu, Fangli;Lin, Xianfu. And the article was included in Polymer in 2011.Reference of 106-79-6 This article mentions the following:
We developed a three-component, one pot biocatalytic polymerization to prepare amphiphilic diblock methoxy poly(ethylene glycol)-b-poly(profen amide-co-esters) (mPEG-PPAE) copolymers under the catalysis of Novozym-435 performed in di-Ph ether at 85° in vacuum for 48 h. 13 mPEG-PPAE copolymers with different profens, dicarboxylates, or PEG were designed and prepared as carriers for the sustained release of the ketoprofen, naproxen and ibuprofen amides. Their structure was characterized by FT-IR, 1H NMR, and GPC measurements. These copolymers can readily self-assemble into nanosized micelles with the well dispersed sphere in aqueous solution, which were confirmed by DLS and TEM. The size of the micelles was influenced by the copolymer concentrations, and the higher copolymer concentration lead to the smaller size. The in vitro ibuprofen amide sustained release behavior indicated that the copolymer is highly sensitive to acid environment, and the release of ibuprofen amide can be effectively controlled. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Reference of 106-79-6).
Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Reference of 106-79-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics