An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process was written by Prichystalova, R.;Caron-Beaudoin, E.;Richardson, L.;Dirkx, E.;Amadou, A.;Zavodna, T.;Cihak, R.;Cogliano, V.;Hynes, J.;Pelland-St-Pierre, L.;Verner, M. A.;van Tongeren, M.;Ho, V.. And the article was included in Journal of Exposure Science & Environmental Epidemiology in 2021.Reference of 84-61-7 This article mentions the following:
Endocrine disrupting chems. (EDCs) are exogenous substances that interfere with the endocrine system and cause adverse effects. We aimed to classify the effects of 24 known EDCs, prevalent in certain occupations, according to four modes of action (estrogenic, antiestrogenic, androgenic, and/or antiandrogenic). The state of the evidence of each EDC on sex hormone function was summarized and reviewed by an expert panel. For each mode of action, the experts evaluated the likelihood of endocrine disruption in five categories: “No”, “Unlikely”, “Possibly”, “Probably”, and “Yes”. Seven agents were categorized as “Yes,” or having strong evidence for their effects on sex hormone function (antiandrogenic: lead, arsenic, butylbenzyl phthalate, di-Bu phthalate, dicyclohexyl phthalate; estrogenic: nonylphenol, bisphenol A). Nine agents were categorized as “Probable,” or having probable evidence (antiandrogenic: bis(2-ethylhexyl)phthalate, nonylphenol, toluene, bisphenol A, diisononyl phthalate; androgenic: cadmium; estrogenic: copper, cadmium and; anti-estrogenic: lead). Two agents (arsenic, polychlorinated biphenyls) had opposing conclusions supporting both “probably” estrogenic and antiestrogenic effects. This synthesis will allow researchers to evaluate the health effects of selected EDCs with an added level of precision related to the mode of action. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Reference of 84-61-7).
Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 84-61-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics