Stereoselective Synthesis of Z-Vinylsilanes via Palladium-Catalyzed Direct Intermolecular Silylation of C(sp2)-H Bonds was written by Pan, Jin-Long;Chen, Chao;Ma, Zhi-Gang;Zhou, Jia;Wang, Li-Ren;Zhang, Shu-Yu. And the article was included in Organic Letters in 2017.HPLC of Formula: 587-88-2 This article mentions the following:
An efficient and convenient Pd-catalyzed direct intermol. silylation of C(sp2)-H bonds by using disilanes as the Si source with the assistance of a readily removable bidentate directing group is reported. This strategy provided a regio- and stereoselective protocol for exclusive synthesis of Z-vinylsilanes with reasonable to excellent yields and good functional group compatibility. Silylation of the isolated palladacycle intermediate revealed the Z-stereoselective pathway. Also, the practicality and effectiveness of this method were illustrated by a gram-scale experiment and further functionalization of the silylation product. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2HPLC of Formula: 587-88-2).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 587-88-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics