Synthesis of Thiazoles and Isothiazoles via Three-Component Reaction of Enaminoesters, Sulfur, and Bromodifluoroacetamides/Esters was written by Ma, Xingxing;Yu, Xiaoxia;Huang, Hua;Zhou, Yao;Song, Qiuling. And the article was included in Organic Letters in 2020.Reference of 33166-79-9 This article mentions the following:
A three-component strategy for the synthesis of thiazoles, e.g., I, and isothiazoles, e.g., II, has been developed by employing enaminoesters, fluorodibromoamides/ester, and sulfur. The thiazoles and isothiazoles were formed via two C-F bond cleavages along with the formation of new C-S, C-N, and N-S bonds. The strategy provides high selectivity for the synthesis of thiazoles/isothiazoles, which have vital applications in drug discovery and development. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Reference of 33166-79-9).
Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 33166-79-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics