Isoindolinone ureas: a novel class of KDR kinase inhibitors was written by Curtin, Michael L.;Frey, Robin R.;Heyman, H. Robin;Sarris, Kathy A.;Steinman, Douglas H.;Holmes, James H.;Bousquet, Peter F.;Cunha, George A.;Moskey, Maria D.;Ahmed, Asma A.;Pease, Lori J.;Glaser, Keith B.;Stewart, Kent D.;Davidsen, Steven K.;Michaelides, Michael R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Formula: C8H4N2O This article mentions the following:
A series of substituted isoindolinone ureas was prepared and evaluated for enzymic and cellular inhibition of KDR kinase activity. Several of these analogs, such as I, are potent inhibitors of KDR both enzymically (<50 nM) and cellularly (â?00 nM). A 3D KDR/CDK2/MAP kinase overlay model with several structurally related tyrosine kinase inhibitors was used to predict the binding interactions of the isoindolinone ureas with the KDR active site. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Formula: C8H4N2O).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Formula: C8H4N2O
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics