Design, Synthesis, and Biological Evaluation of Novel, Highly Active Soft ROCK Inhibitors was written by Boland, Sandro;Bourin, Arnaud;Alen, Jo;Geraets, Jacques;Schroeders, Pieter;Castermans, Karolien;Kindt, Nele;Boumans, Nicki;Panitti, Laura;Fransen, Silke;Vanormelingen, Jessica;Stassen, Jean Marie;Leysen, Dirk;Defert, Olivier. And the article was included in Journal of Medicinal Chemistry in 2015.Product Details of 1195768-18-3 This article mentions the following:
ROCK1 and ROCK2 play important roles in numerous cellular functions, including smooth muscle cell contraction, cell proliferation, adhesion, and migration. Consequently, ROCK inhibitors are of interest for treating multiple indications including cardiovascular diseases, inflammatory and autoimmune diseases, lung diseases, and eye diseases. However, systemic inhibition of ROCK is expected to result in significant side effects. Strategies allowing reduced systemic exposure are therefore of interest. In a continuing effort toward identification of ROCK inhibitors, we here report the design, synthesis, and evaluation of novel soft ROCK inhibitors displaying an ester function allowing their rapid inactivation in the systemic circulation. Those compounds, e.g. I, display subnanomolar activity against ROCK and strong differences of functional activity between parent compounds and expected metabolites. The binding mode of a representative compound was determined exptl. in a single-crystal X-ray diffraction study. Enzymes responsible for inactivation of these compounds once they enter systemic circulation are also discussed. In the experiment, the researchers used many compounds, for example, Methyl 3-amino-2-fluorobenzoate (cas: 1195768-18-3Product Details of 1195768-18-3).
Methyl 3-amino-2-fluorobenzoate (cas: 1195768-18-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 1195768-18-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics