The organocatalytic highly enantioselective Knoevenagel condensation: applications in the synthesis of various chiral amide derivatives was written by Ashokkumar, Veeramanoharan;Siva, Ayyanar;Sankar, Balakrishnan. And the article was included in Journal of the Iranian Chemical Society in 2019.Application of 1190-39-2 This article mentions the following:
In this work, efficient organocatalysts were designed, synthesized and successfully applied to the Knoevenagel condensation. In this reaction, different α-branched aldehydes were treated with various malonate compounds to give the desired unsaturated diester products [R1 = H, 4-Me, 3-F, etc.; R2 = Me, Et, Bn, etc.] up to 97% yield and excellent e.r up to 99.68:0.32 under the mild reaction conditions. Moreover, the Knoevenagel product, unsaturated diesters I was converted into different chiral amide derivatives II [R3 = n-BuNH, PhNH, N-morpholinyl, pyrrolidin-1-yl, 4-pyridylamino] in higher enantioselectivity. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Application of 1190-39-2).
malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 1190-39-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics