Month: December 2022

Synthesis of 2,2-dimethyl-5-hydroxymethyl-1,3-dioxane was written by Li, Peijie;Xu, Zheng;Wu, Xiaochun;Wu, Yong. And the article was included in Huaxi Yaoxue Zazhi in 2001.Name: Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate This article mentions the following:

2,2-Dimethyl-5-hydromethyl-1,3-dioxane was synthesized from di-Et malonate by condensation with formaldehyde in the presence of KHCO₃, further condensation with 2,2-dimethoxypropane, decarboxylation in DMSO-NaCl, and reduction with LiAlH₄, provide product with over all yield 41%. In the experiment, the researchers used many compounds, for example, Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7Name: Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate).

Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Name: Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crystallinity enhancement of extruded polypropylene containing poly(vinyl alcohol) fibers prepared in situ was written by Nishikawa, Riho;Eno, Ayaka;Janchai, Khunanya;Han, Ruiqi;Kida, Takumitsu;Mori, Toyoichiro;Aridome, Norifumi;Miyamoto, Akira;Yamaguchi, Masayuki. And the article was included in Polymer in 2022.Application In Synthesis of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) This article mentions the following:

The present paper describes a novel method for reinforcing isotactic polypropylene (PP) by adding poly(vinyl alc.) (PVA) fibers prepared by melt-stretching. Low-viscosity PVA droplets were deformed into fibers in the molten PP by melt-stretching them beyond the m.p. of PVA. When the obtained composite was extruded below the m.p. of PVA, the fibers became oriented toward the flow direction. The PVA demonstrated marked nucleating activity with regard to PP crystallization, which was further promoted by enlargement of the surface area by fibrillization. As a result, there was virtually no orientation relaxation of the PP chains with an increase in crystallinity, which explains the improvement in rigidity of the reinforced composite. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Application In Synthesis of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application In Synthesis of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs) was written by Lu, Yanli;Mao, Fei;Li, Xiaokang;Zheng, Xinyu;Wang, Manjiong;Xu, Qing;Zhu, Jin;Li, Jian. And the article was included in Journal of Medicinal Chemistry in 2017.Recommanded Product: 16413-26-6 This article mentions the following:

Stem cell factor receptor (c-KIT) and platelet derived growth factor receptor alpha (PDGFRα) kinases play an important role in gastrointestinal stromal tumors (GISTs). Here, the authors have discovered an c-KIT/PDGFRα dual inhibitor, compound I, with single-digit nanomolar potency against c-KIT and PDGFRα. Compared to Imatinib (1), I showed better antiproliferative efficacy against various TEL-c-KIT/PDGFRα-BaF3 isogenic cells, including three 1-resistant BaF3 cell lines, as well as against GIST-T1 and GIST-882 cell lines. Furthermore, compound I showed a good KinomeScan selectivity (468 kinases) (S score (1) = 0.01 at 1 μM concentration), good metabolic stability in liver microsomes, and no hERG inhibitory activity. It was worth noting that I inhibited GIST-T1 tumor growth (TGI = 81.5%) and even the BaF3-TEL-cKIT-T670I tumor progression (TGI = 41.9%, 1-resistant GISTs) at a dosage of 100 mg/kg/day without exhibiting apparent toxicity. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tetrasubstituted 1,3-Enynes by Gold-Catalyzed Direct C(sp²)-H Alkynylation of Acceptor-Substituted Enamines was written by Han, Chunyu;Tian, Xianhai;Zhang, Huili;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in Organic Letters in 2021.SDS of cas: 13669-10-8 This article mentions the following:

A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp²)-H functionalization of alkenes, offering 26 enynes in 62-92% yield with excellent functional group tolerance. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8SDS of cas: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors was written by Angibaud, Patrick;Van Emelen, Kristof;Decrane, Laurence;van Brandt, Sven;ten Holte, Peter;Pilatte, Isabelle;Roux, Bruno;Poncelet, Virginie;Speybrouck, David;Queguiner, Laurence;Gaurrand, Sandrine;Marien, Ann;Floren, Wim;Janssen, Lut;Verdonck, Marc;van Dun, Jacky;van Gompel, Jacky;Gilissen, Ron;Mackie, Claire;Du Jardin, Marc;Peeters, Jozef;Noppe, Marc;Van Hijfte, Luc;Freyne, Eddy;Page, Martin;Janicot, Michel;Arts, Janine. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Synthetic Route of C10H20N2O3 This article mentions the following:

Pursuing our efforts in designing 5-pyrimidylhydroxamic acid anti-cancer agents, we have identified a new series of potent histone deacetylase (HDAC) inhibitors. These compounds exhibit enzymic HDAC inhibiting properties with IC₅₀ values in the nanomolar range and inhibit tumor cell proliferation at similar levels. Good solubility, moderate bioavailability, and promising in vivo activity in xenograft model made this series of compounds interesting starting points to design new potent HDAC inhibitors. In the experiment, the researchers used many compounds, for example, tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1Synthetic Route of C10H20N2O3).

tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Synthetic Route of C10H20N2O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Infant supplement quality evaluation by inductively coupled plasma – mass spectrometry, gas chromatography, and isotope ratio mass spectrometry was written by Dehelean, A.;Kovacs, E. D.;Magdas, D. A.;Cristea, G.;Voica, C.;Feher, I.;Kovacs, M. H.;Marincas, O.;Zhang, Z.;Li, P.;Zang, Q.. And the article was included in Analytical Letters in 2019.Computed Properties of C10H20O2 This article mentions the following:

There is a growing interest by both consumers and industry in the development of food products with functional properties or health benefits. These food supplements are especially important for infants; thus their safety must be guaranteed. However, the use of different raw materials, process technologies, and storage technologies may impact food quality and safety in undesirable ways. The purpose of this work was to investigate com. available infant food supplements targeting: (1) content of macro/micro nutrients and toxic metals; (2) volatile organic compounds that contribute to flavor and aroma composition of food; (3) content of fatty acids; and (4) δ¹³C to determine the origin of the raw material for these products. These were performed in order to evaluate their quality with respect to nutraceutical value and safety. Different chemometric methods were used for the statistical interpretation of the data including anal. of variance (ANOVA), Pearson correlation, principal component anal. (PCA), and linear discriminant anal. (LDA). In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1Computed Properties of C10H20O2).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C10H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: Design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition was written by Capela, Rita;Oliveira, Rudi;Goncalves, Lidia M.;Domingos, Ana;Gut, Jiri;Rosenthal, Philip J.;Lopes, Francisca;Moreira, Rui. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:

A series of artemisinin-vinyl sulfone hybrid mols. with the potential to act in the parasite food vacuole via endoperoxide activation and falcipain inhibition was synthesized and screened for antiplasmodial activity and falcipain-2 inhibition. All conjugates were active against the Plasmodium falciparum W2 strain in the low nanomolar range and those containing the Leu-hPhe core inhibited falcipain-2 in low micromolar range. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Expedient Synthesis of Substituted Benzoheterocycles using 2-Butoxy-2,3-dihydrofurans as [4+2] Benzannulation Reagents was written by Liu, Changhui;Huang, Wenbo;Wang, Man;Pan, Bin;Gu, Yanlong. And the article was included in Advanced Synthesis & Catalysis in 2016.Category: esters-buliding-blocks This article mentions the following:

2-Alkoxy-2,3-dihydrofurans were found to be versatile benzannulation reagents. Indoles can be synthesized in good to excellent yields via the [4+2] annulation of 2-butoxy-2,3-dihydrofuran with pyrroles catalyzed by copper bromide. With the same protocol, carbazoles can also be obtained when indoles are used as starting material with the aid of p-toluenesulfonic acid. This type of benzannulation reagent can also be used to synthesize benzofuran, benzothiophene and naphthalene derivatives in the presence of a catalytic amount of triflic acid in moderate yields. This benzannulation protocol features wide substrate scope and mild reaction condition. Moreover, most of examples have a good regioselectivity. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Category: esters-buliding-blocks).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Migration of Irganox 1010, Irganox 1076, and Titanium dioxide into Doogh and corresponding food simulant from laminated packaging was written by Forooghi, Elaheh;Ahmadi, Shervin;Farhoodi, Mehdi;Mortazavian, Amir M.. And the article was included in Journal of Environmental Health Science and Engineering in 2022.Synthetic Route of C73H108O12 This article mentions the following:

Doogh is a famous Iranian drink based on fermented milk. Laminated film is one of the most common packaging for this beverage in Iran. So, chem. substances of the packaging may migrate to the Doogh and endanger human health. In this research, High-Performance Liquid Chromatog. (HPLC) was used to determine the migration of Irganox 1010 and Irganox 1076 from the contact layer and inductively coupled plasma for Titanium dioxide (TiO₂) from the second layer of three-layer laminate films into Doogh and acetic acid 3% (w/v). The influence of different storage temperatures and times was investigated by evaluating the samples stored in various conditions. The morphol., thermal and mech. properties of the film, before and after contact with food simulant were further studied. The highest amount of Irganox 1010 concentration of the tested samples were 0.8 ± 0.04 mg/l in acetic acid 3% (w/v), and 0.62 ± 0.04 mg/l in Doogh. The highest amount of TiO₂ concentration were 0.25 ± 0.04 mg/l in acetic acid 3% (w/v), and 0.12 ± 0.02 mg/l in Doogh. The migration of Irganox 1076 was determined, but it was not detected. The results indicated that the food simulant had no significant effect on the microstructure and thermal properties of the polymer, but it reduced the mech. properties. The results indicate the possible migrating of Irganox 1010 and TiO₂ through laminate packaging into Doogh in some storage conditions. Since the migration value was low, the mentioned film was proven safe for Doogh packaging, imposing no hazards on human health. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Synthetic Route of C73H108O12).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C73H108O12

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Genetic and physical mapping of the Rhodobacter sphaeroides photosynthetic gene cluster from R-prime pWS2 was written by Wu, Yongqiang;MacGregor, Barbara J.;Donohue, Timothy J.;Kaplan, Samuel;Yen, Bill. And the article was included in Plasmid in 1991.Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate This article mentions the following:

Plasmid pWS2 is an R68.45 chimera originally isolated as an R-prime which complemented the R. sphaeroides bch-420 allele. PWS2 is also able to complement a wide range of R. sphaeroides pigment and photosynthetic mutants employing nitrosoguanidine, transposon or insertion-generated mutations effecting puhA, puc, puf, cycA, bch, and crt genes. A combination of orthogonal-field-alternation gel electrophoresis, transverse alternating field gel electrophoresis, and conventional electrophoresis have been used to estimate the size of pWS2 at ≃168.3 ± 3.5 kb. A restriction map of the ≃109 kb of R. sphaeroides insert DNA was generated by partial and complete restriction endonuclease digestion coupled with Southern hybridization anal. using either gene-specific or junction fragment probes. Genes encoding bacteriochlorophyll (Bchl)-binding proteins (pufBALMX, PucBA, and puhA), cytochrome c₂ (cycA), and enzymes involved in Bchl (bch) and carotenoid (crt) biosynthesis have been shown to reside within a contiguous 53-kb region of the R. sphaeroides DNA present on pWS2. The puf operon lies at one end of the 53-kb segment, while the genes puhA, cycA, and pucBA, the latter 2 of which are located within ≃12.0 kb of each other, define the other end of this 53-kb region. The genetic and phys. mapping data provided in this paper are discussed in terms of the similarities and differences in the organization of the photosynthetic gene cluster between R. sphaeroides and other photosynthetic bacteria as well as highlighting the use of pWS2 in studies of photosynthetic gene structure and function. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics