Month: December 2022

Boehme, H. published the artcilePreparation, properties, and rearrangement of (β-alkoxycarbonylalkylidene)ammonium salts, Application of Ethyl 3-(dimethylamino)acrylate, the publication is Tetrahedron (1977), 33(8), 841-5, database is CAplus.

Methylation and protonation of β-alkoxycarbonyl enamines gave iminium salts which were characterized by 1H NMR spectroscopy. E.g., methylation with MeI and protonation with HCl of Me2NCH:CMeCO2Et gave (Me2N:CHCMe2CO2Et)+ (I) and (Me2N:CHCHMeCO2Et)+, resp. The reactions of the iminium salts with PhMgBr, MeMgBr, dimedone, and PhCOMe were studied; in some cases, secondary reactions involving amine elimination occurred. E.g., I with MeMgBr and PhCOMe gave Me2NCHMeCMe2CO2Et and PhCOCH:CHCMe2CO2Et, resp.

Tetrahedron published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Application of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sarki, Naina published the artcileSimple RuCl₃-catalyzed N-Methylation of Amines and Transfer Hydrogenation of Nitroarenes using Methanol, Synthetic Route of 10287-53-3, the publication is ChemCatChem (2021), 13(7), 1722-1729, database is CAplus.

Methanol is a potential hydrogen source and C₁ synthon, which finds interesting applications in both chem. synthesis and energy technologies. The effective utilization of this simple alc. in organic synthesis is of central importance and attracts scientific interest. Herein, a clean and cost-competitive method with the use of methanol as both C₁ synthon and H₂ source for selective N-methylation of amines by employing relatively cheap RuCl₃.xH₂O as a ligand-free catalyst. This readily available catalyst tolerates various amines comprising electron-deficient and electron-donating groups and allows them to transform into corresponding N-methylated products in moderate to excellent yields. In addition, few marketed pharmaceutical agents (e.g., venlafaxine and imipramine) were also successfully synthesized via late-stage functionalization from readily available feedstock chems., highlighting synthetic value of this advanced N-methylation reaction. Using this platform, also attempted tandem reactions with selected nitroarenes to convert them into corresponding N-methylated amines using MeOH under H₂-free conditions including transfer hydrogenation of nitroarenes-to-anilines and prepared drug mols. (e.g., benzocaine and butamben) as well as key pharmaceutical intermediates. Further enable one-shot selective and green syntheses of 1-methylbenzimidazole using ortho-phenylenediamine (OPDA) and methanol as coupling partners.

ChemCatChem published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Synthetic Route of 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Even, Catherine published the artcileAFM, x-ray diffraction and optical microscopy studies of faceted droplets of a thermotropic bicontinuous cubic mesophase, COA of Formula: C15H14O3, the publication is ChemPhysChem (2002), 3(12), 1031-1034, database is CAplus and MEDLINE.

Droplets of a new thermotropic cubic mesophase are observed at room temperature both by optical microscopy and at. force microscopy. With AFM, steps on the facets are involved in the faceting mechanism of these droplets. The AFM image shows the detail of a facet’s corner and a rough area in between.

ChemPhysChem published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, COA of Formula: C15H14O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yasui, Kengo published the artcileUse of π-allylpalladium as a nucleophile via an alkyl-allyl exchange reaction with alkylzinc, Category: esters-buliding-blocks, the publication is Tetrahedron Letters (1993), 34(47), 7619-22, database is CAplus.

Allylation of carbonyl compounds (aldehydes, ketones, esters, lactones, acid anhydrides) proceeds smoothly at room temperature by the reaction of a carbonyl compound, an allylic benzoate or allylic Ph ether, diethylzinc, and a catalytic amount of Pd(0)-complex in THF under N₂. E.g., reaction of 1.0 mmol E-PhCH:CHCHO with 1.2 mmol allyl benzoate in THF containing 0.05 mmol Pd(PPh₃)₄ and 2.4 mmol Et₂Zn in hexane gave 97% E-PhCH:CHCH(OH)CH₂CH:CH₂.

Tetrahedron Letters published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C7H11N, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dunkelblum, Ezra published the artcileSex attractant blends for field trapping of Agrotis segetum males (Lepidoptera: Noctuidae) in Israel and Germany, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate, the publication is Zeitschrift fuer Naturforschung, C: Journal of Biosciences (1985), 40C(3-4), 272-7, database is CAplus.

Lures for a monitoring system based on sex attractant trapping of A. segetum males were elaborated. Various mixtures of (Z)-5-decenyl acetate  [67446-07-5], (Z)-7-dodecenyl acetate  [14959-86-5], (Z)-9-dodecenyl acetate  [16974-11-1], (Z)-9-tetradecenyl acetate  [16725-53-4], decyl acetate  [112-17-4] and dodecyl acetate  [112-66-3] were tested in 20 different blends. From comparison of all the trap catches, a 4-component lure consisting of (Z)-5-decenyl, (Z)-7-dodecenyl, (Z)-9-tetradecenyl and dodecyl acetate is recommended for monitoring of A. segetum in both countries.

Zeitschrift fuer Naturforschung, C: Journal of Biosciences published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Suriano, Raffaella published the artcileEnvironmental Profile and Technological Validation of New High-T_gUnsaturated Polyesters from Fully Bio-Based Monomers and Reactive Diluents, Product Details of C7H10O4, the publication is Journal of Polymers and the Environment (2021), 29(4), 1122-1133, database is CAplus.

This study was focused on the synthesis and characterization of a fully bio-based unsaturated polyester resin (UPR) with good thermal properties suitable for the com. production of composite polymers. UPRs based on different ratios of bio-based furan dicarboxylic acid (FDCA), itaconic acid, and diols were synthesized. The unsaturated polymers prepared were evaluated by differential scanning calorimetry, gel permeation chromatog., FTIR and ¹H-NMR spectroscopy. The results showed pos. effects of FDCA on the glass transition temperature (T_g) of these fully bio-based polyesters, especially when FDCA was combined with 1,2-propanediol. Optimal values of T_g were obtained in the range of 30-32°C for UPRs synthesized starting with a higher concentration of FDCA in the monomer feed. The possibility of substituting styrene, which usually acts as a reactive diluent, with a greener and safer alternative during the crosslinking of UPRs, was also explored. Two bio-based reactive diluents were considered: di-Me itaconate (DMI) and butanediol dimethacrylate. After crosslinking, an average T_g of 75°C and a good crosslinking efficiency indicated by a gel content of 90% were achieved for the fully bio-based polyester obtained under milder reaction conditions and dilution with DMI. Life cycle assessment was performed on selected UPRs, and comparison with a reference fossil-based resin in terms of the calculated category indicator results confirmed the lower environmental impact of the newly prepared bio-based polyesters.

Journal of Polymers and the Environment published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C12H15ClO3, Product Details of C7H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Haifei published the artcileAg(I)/CAAA-Amidphos Complex Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Acrylates for the Formal Synthesis of (+)-Ibophyllidine, HPLC of Formula: 103-26-4, the publication is Synlett (2021), 32(14), 1437-1446, database is CAplus.

In this work, the authors introduced a multifunctional Ag(I)/CAAA-amidphos complex catalyzed asym. 1,3-dipolar cycloaddition of acrylates with α-imino esters, affording a series of 2,4,5-trisubstituted endo-pyrrolidines, e.g., I, in good yields (up to 97%) with high enantioselectivities (up to 98% ee). Meanwhile, the catalytic system was also applied in the three-component one-pot reaction of α-imino esters formed in situ under the action of N,N’-diisopropylcarbodiimide. In addition, the gram-scale reaction was realized for the formal synthesis of (+)-ibophyllidine (II) in eight steps.

Synlett published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C6H3ClIN3, HPLC of Formula: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Akcha, Selma published the artcileSynthesis, characterization, solution equilibria, DFT study, DNA binding affinity and cytotoxic properties of a cobalt(II) complex with a 5-pyrazolone ligand, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is Inorganica Chimica Acta (2018), 738-748, database is CAplus.

The authors’ work describes the synthesis, the complexation and the characterization of a cobalt(II) complex with a 5-pyrazolone ligand carrying a thioamide group on N¹ position. The study of the complexation in solution allowed the determination of the stability constants of the complex and the distribution of the species involving Co(II) over the whole pH-range. The solid cobalt(II) complex has then been synthesized and fully characterized by IR, electronic, EPR and mass spectrometries, in addition to magnetic and voltammetric measurements. The data clearly indicated an octahedral high spin Co(II) complex with two mononeg. mols. of the N,S-ligand, and two water mols., likely in a cis position because of the high anisotropy. DFT calculations performed on both the ligand and the complex structures allowed the authors to study the spectral features, and to propose the most fitting structures to the exptl. data. The interaction of the 5-pyrazolone ligand and its cobalt(II) complex with fish-sperm DNA has been studied by electronic spectrometry and cyclovoltammetry. Intercalation has been identified as a binding mode and the strength of the binding assessed. In order to explore eventual cytotoxic and/or cytostatic properties of the authors’ compounds, the ligand and the cobalt complex have been tested on PC-3 (human prostate carcinoma) and HT-29 (human colon carcinoma) using sulforhodamine B (SRB) assay.

Inorganica Chimica Acta published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Choudhary, Yogesh S. published the artcileBranched Ligand Ethyl 2-Mercaptopropionate as a Stabilizer for CdTe Quantum Dots and its use as a Cu²⁺ Ions Probe in Aqueous Medium, Name: Ethyl 2-mercaptopropanoate, the publication is ChemistrySelect (2020), 5(1), 32-39, database is CAplus.

In the present work, we explored the possibility of using a novel stabilizing ligand namely Et 2-mercaptopropionate for the synthesis of CdTe quantum dots (QDs). The QDs were synthesized and stabilized by the ligand and it was realized to be emitting at 560 nm. Extensive microscopic and photo phys. characterization were carried out in order to unearth the nature of the QDs synthesized. Interestingly, it was observed that, the photoluminescence emission of as synthesized QDs were getting quenched linearly in the presence of Cu²⁺, which prompt us to make use of these QDs for the detection of Cu²⁺ ions in aqueous media. A detailed mechanism of quenching was also proposed. The linear range over which the QDs was selective to Cu²⁺ ions was from 0.5 nM to 129.5 nM with a detection limit (LOD) of 0.5 nM providing a pathway for the QDs based Cu²⁺ probe.

ChemistrySelect published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Name: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics