Month: December 2022

Horiike, Michio published the artcileMass spectrometric indication of double-bond position in dodecenyl acetates based on a fuzzy classification, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate, the publication is Rapid Communications in Mass Spectrometry (1989), 3(4), 100-1, database is CAplus.

Ten positional isomers of dodecenyl acetate were analyzed by conventional combined gas chromatog./electron-ionization mass spectrometry. The relative intensities of some predominant fragments in the isomers examined varied with the double-bond position in the chain. The mass spectra were interpreted in terms of the standard parameters, similarity coefficients, clustering weight and clustering coefficients The original double-bond position in the acetates was located unambiguously.

Rapid Communications in Mass Spectrometry published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Recommanded Product: (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Han, Yong-Yue published the artcileProtective effect of dimethyl itaconate against fibroblast-myofibroblast differentiation during pulmonary fibrosis by inhibiting TXNIP, Safety of Dimethyl itaconate, the publication is Journal of Cellular Physiology (2021), 236(11), 7734-7744, database is CAplus and MEDLINE.

Fibroblast-myofibroblast differentiation (FMD) is a critical cellular phenotype during the occurrence and deterioration of pulmonary fibrosis (PF). FMD can increase with an elevated level of reactive oxygen species (ROS) on fibroblasts under oxidative stress. Thioredoxin-interacting protein (TXNIP) is an α-arrestin family protein that regulates the level of intracellular ROS. Nuclear factor erythroid 2-related factor 2 (Nrf2) can protect against FMD in PF. However, the relationship between Nrf2 and TXNIP in FMD remains elusive. Therefore, we established TGF-β1-induced FMD in vitro and bleomycin (BLM)-induced mouse PF model in vivo to explore whether the activation of Nrf2 can inhibit TXNIP-mediated FMD in PF. Di-Me itaconate (DMI) was selected to activate Nrf2. Our results showed that TXNIP was elevated and FMD was aggravated in mice lung tissues after BLM administration compared with the saline group. Inversely, Nrf2 decreased TXNIP expression and alleviated FMD in PF. In vitro, TXNIP overexpression enhanced FMD and increased the level of ROS. In contrast, TXNIP deficiency by small interfering RNA (siRNA) attenuated TGF-β1-induced FMD and reduced ROS. An increase in ROS by H₂O₂ can upregulate TXNIP expression. Moreover, Nrf2 also inhibited TGF-β1-induced FMD and the increase of ROS, with reducing expression of TXNIP, and the inhibitory effect was better than TXNIP siRNA. These results suggest that activation of Nrf2 by DMI can protect against PF via inhibiting TXNIP expression. Our study may provide new therapeutic targets and treatment approaches for PF.

Journal of Cellular Physiology published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Safety of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Yu-An published the artcileA Change from Kinetic to Thermodynamic Control Enables trans-Selective Stereochemical Editing of Vicinal Diols, Name: Dimethyl fumarate, the publication is Journal of the American Chemical Society (2022), 144(1), 599-605, database is CAplus and MEDLINE.

Herein, the selective, catalytic isomerization of cis-1,2-diols to trans-diequatorial-1,2-diols is reported. The method employs triphenylsilanethiol (Ph₃SiSH) as a catalyst and proceeds under mild conditions in the presence of a photoredox catalyst and under blue light irradiation The method is highly chemoselective, broadly functional group tolerant and provides concise access to trans-diol products which are not readily obtained using other methods. Mechanistic studies reveal that isomerization proceeds through a reversible hydrogen atom transfer pathway mediated by the silanethiol catalyst.

Journal of the American Chemical Society published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C10H16Br3N, Name: Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Weiqiang published the artcileSynthesis of ethyl N,N-dimethylaminoacrylate, Name: Ethyl 3-(dimethylamino)acrylate, the publication is Huagong Shengchan Yu Jishu (2008), 15(4), 29-31, database is CAplus.

Synthetic routes of Et N,N-dimethylaminoacrylate, imine complexation, high-pressure of carbon monoxide synthesis, aldol condensation, were compared with their advantages and disadvantages. The method of aldol condensation was started from Et formate and Et acetate, reacted with sodium or sodium hydride, to obtain sodium Et formylacetate, then reacted with dimethylamine hydrochloride to obtain the final product. The total yield was 60%. This process had many advantages, such as mild reaction conditions, simple procedure, high atom economy and less pollution, so it was suitable for industrial production

Huagong Shengchan Yu Jishu published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C15H14O3, Name: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chalyk, Bohdan published the artcileUnexpected Isomerization of Oxetane-Carboxylic Acids, Related Products of esters-buliding-blocks, the publication is Organic Letters (2022), 24(26), 4722-4728, database is CAplus and MEDLINE.

Many oxetane-carboxylic acids were found to be unstable. They easily isomerized into new (hetero)cyclic lactones while being stored at room temperature or slightly heated. Chemists should keep in mind the high instability of these mols., as this could dramatically affect the reaction yields and led to neg. results (especially in those reactions that require heating).

Organic Letters published new progress about 1207175-04-9. 1207175-04-9 belongs to esters-buliding-blocks, auxiliary class Oxetane,Ester, name is Ethyl 2-(oxetan-3-yl)acetate, and the molecular formula is C7H12O3, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Blank-Porat, Diana published the artcileThe anticancer prodrugs of butyric acid AN-7 and AN-9, possess antiangiogenic properties, Recommanded Product: (Pivaloyloxy)methyl butyrate, the publication is Cancer Letters (Amsterdam, Netherlands) (2007), 256(1), 39-48, database is CAplus and MEDLINE.

The antiangiogenic and antineoplastic activities of the butyric acid prodrugs AN-7 and AN-9 were demonstrated in vitro with HUVEC by inhibition of proliferation and vascular tubes formation, enhanced apoptosis, and inhibition of 22Rv-1 cells migration. In the s.c. implanted human prostate tumors (22Rv-1) in nude mice, AN-7 significantly inhibited Ki-67, HIF-1α, HER-2/neu, bFGF and increased PTEN level. AN-7 and AN-9 reduced Hb accumulation in matrigel plugs implanted s.c. in Balb-c mice. Herein, we show that the anticancer activity of AN-7 and AN-9 can be attributed in part to their antiangiogenic activities suggesting potential therapeutic benefits for prostate cancer patients.

Cancer Letters (Amsterdam, Netherlands) published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Recommanded Product: (Pivaloyloxy)methyl butyrate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rassadin, Valentin A. published the artcileAccess to a Wide Range of Sultams by Cyclodialkylation of α-Substituted Methanesulfonanilides, Synthetic Route of 19788-49-9, the publication is European Journal of Organic Chemistry (2012), 2012(26), 5028-5037, S5028/1-S5028/169, database is CAplus.

A wide range of five- and six-membered sultams bearing an α-ethoxycarbonyl-α-Me substituent or an α-aryl group (17 examples) were synthesized by the cyclodialkylation of α-substituted methanesulfonanilides with α,ω-dihaloalkanes in the presence of K₂CO₃ or under phase-transfer catalysis (PTC) conditions. Upon treatment with K₂CO₃ in N,N-dimethylformamide (DMF) or NaH in DMSO (DMSO), N-(2,3-dibromopropyl)-α-toluenesulfonanilides furnished different 1,3-diaryl-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxides in good to excellent yields (51-88 %, 16 examples). The 4-methoxyphenyl (PMP) group was easily removed from the sultam nitrogen atom by treatment of the corresponding bicyclic sultams with cerium(IV) ammonium nitrate in acetonitrile (71-84 % yield, 6 examples).

European Journal of Organic Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Stakhi, Sergey A. published the artcileDetermination of Monomer Reactivity Ratios in Controlled Copolymerization of Acrylonitrile with Unsaturated Methyl Esters, Synthetic Route of 617-52-7, the publication is Polymer Science, Series B: Polymer Chemistry (2020), 62(3), 169-175, database is CAplus.

This paper reports the investigation of copolymerization of acrylonitrile with Me acrylate, di-Me maleate, di-Me fumarate and di-Me itaconate via atom transfer radical polymerization mechanism using copper bromide as a catalyst in combination with tris(2-pyridylmethyl)amine as a ligand. The reactivity ratios of monomers were evaluated using the Finemann-Ross and Kelen-Tudos methods basing on the copolymer composition determined by ¹H NMR spectroscopy. It was found that reversible deactivation mechanism has no significant influence on the monomer reactivity ratios. It was found that among the tested comonomers Me acrylate and di-Me itaconate seem to be the most suitable ones for obtaining well-defined copolymers of acrylonitrile.

Polymer Science, Series B: Polymer Chemistry published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C17H14O5, Synthetic Route of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Stakhi, Sergey A. published the artcileTandem catalysis of Atom Transfer Radical Polymerization of acrylonitrile based on simultaneous use of two copper complexes, Recommanded Product: Dimethyl itaconate, the publication is Journal of Polymer Research (2021), 28(12), 457, database is CAplus.

The novel approach for conducting ARGET ATRP based on simultaneous use of two copper complexes based on tris[2-(dimethylamino)ethyl]amine (Me₆TREN), 2,2′-bipyridine (bipy) and tris(2-pyridylmethyl)amine (TPMA) in one pot is proposed. This approach allows to increase the rate of polymerization of acrylonitrile and to achieve polymers with high mol. weights The performed electrochem. studies allowed establishing the possible mechanism of tandem catalysis where the more reducing complex mostly acts as activator determining the high polymerization rate while the second one reversible deactivates polymer chain preserving the control over the process. The influence of initiator nature and the ratio between copper catalysts on the polymerization rate and the mol. weight parameters of the samples was studied. It was shown that the proposed system may be applied for obtaining well-defined copolymers of acrylonitrile with Me acrylate and di-Me itaconate via ARGET ATRP mechanism using low copper concentrations

Journal of Polymer Research published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C10H10O2, Recommanded Product: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gemborys, Mark W. published the artcileSynthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate, Quality Control of 6217-68-1, the publication is Journal of Medicinal Chemistry (1978), 21(7), 649-52, database is CAplus and MEDLINE.

The synthesis of N-hydroxyacetaminophen (I) [63975-21-3], a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate II [66682-85-7] is described. K p-nitrophenyl sulfate [6217-68-1] was reduced, acetylated, and treated with sulfatase to give I. I was moderately unstable at physiol. pH and temperature, but II was stable.

Journal of Medicinal Chemistry published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Quality Control of 6217-68-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics