Month: December 2022

Zhou, Hua-Jian published the artcileHydropyridylation of α,β-Unsaturated Esters through Electroreduction of 4-Cyanopyridine, Application of Methyl 3-phenyl-2-propenoate, the publication is Journal of Organic Chemistry (2022), 87(8), 5328-5338, database is CAplus and MEDLINE.

A mild and highly efficient method for the hydropyridylation of α,β-unsaturated esters has been developed. This protocol provides the products smoothly with a wide substrate scope in an undivided cell under ambient conditions. Moreover, studies showed that the scope could be extended to other unsaturated compounds, including enones and aldehydes.

Journal of Organic Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C23H20BN, Application of Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Guosong published the artcileRegioselective Radical Borylation of α,β-Unsaturated Esters and Related Compounds by Visible Light Irradiation with an Organic Photocatalyst, Related Products of esters-buliding-blocks, the publication is Organic Letters (2021), 23(11), 4353-4357, database is CAplus and MEDLINE.

Radical hydroboration reactions have only recently been reported and are still rare. Here the authors describe a photoredox radical hydroboration of α,β-unsaturated esters, amides, ketones, and nitriles with NHC-boranes that uses only an organocatalyst and visible light. The conditions are mild, the substrate scope is broad, and the α/β regioselectivity is high. The reaction requires only the organocatalyst; there is no costly metal, and there are no other additives (base, cocatalyst, initiator).

Organic Letters published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Junlei published the artcileVisible-light-mediated defluorinative cross-coupling of gem-difluoroalkenes with thiols, Computed Properties of 19788-49-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(74), 11103-11106, database is CAplus and MEDLINE.

A visible-light-mediated monofluoroalkenylation through defluorinative cross-coupling of gem-difluoroalkenes RR¹C=CF₂ [R = biphenyl-4-yl, 1-benzofuran-2-yl, 4-(trifluoromethyl)phenyl, etc.; R¹ = H, Ph, 3-(trifluoromethyl)phenyl, 4-methoxyphenyl, etc.; RR¹ = 9H-fluoren-9-yl, [2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy- 2,3-dihydro-1H-inden-1-yl]] with aryl, benzyl, and alkyl thiols R²SH (R² = cyclohexyl, 4-methoxyphenyl, 2-bromophenyl, etc.) has been reported. This novel strategy provides facile and efficient access to tri/tetra-substituted monofluoroalkenes RR¹C=C(F)SR² under mild reaction conditions with good functional group tolerance. Late-stage modification of natural products such as dehydrocholic acid and diosgenin indicated the synthetic potential of this S-H monofluoroalkenylation process.

Chemical Communications (Cambridge, United Kingdom) published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C14H22O2, Computed Properties of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cui, Fei-Hu published the artcileSelective Difunctionalization of Unactivated Aliphatic Alkenes Enabled by a Metal-Metallaaromatic Catalytic System, Formula: C12H14O2, the publication is Journal of the American Chemical Society (2022), 144(5), 2301-2310, database is CAplus and MEDLINE.

The design of organometallic catalysts is crucial in the development of catalytic reactions. Herein, the authors describe a heterometallic [Os-Cu] complex with the characteristics of bimetallics, metallaaroms. and pincer complexes. This complex serves as a highly effective catalyst for selective amino- and oxyselenation of unactivated alkenes. More than 80 examples including challenging substrates of unsym. aliphatic alkenes and amine-based nucleophiles in such reactions are provided. These reactions produce 1,2-difunctionalized products with good yields and high levels of chemo-, regio- and stereoselectivity. The study revealed that (i) the usually inert Os center activates the N- or O-centered nucleophiles, (ii) the Cu-Os bonding and its cooperative effects play essential roles in control the selectivity by bringing the reaction components into close proximity, and (iii) the metallaarom. moiety helps to stabilize the intermediate. These findings provide a versatile platform for catalyst design based on metal-metallaarom. cooperative effects that were not attained previously with bimetallic complexes.

Journal of the American Chemical Society published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Formula: C12H14O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhu, Dunming published the artcileHow carbonyl reductases control stereoselectivity: approaching the goal of rational design, Related Products of esters-buliding-blocks, the publication is Pure and Applied Chemistry (2010), 82(1), 117-128, database is CAplus.

Although Prelog’s rule and two hydrophobic binding pockets model have been used to predict and explain the stereoselectivity of enzymic ketone reduction, the mol. basis of stereo-recognition by carbonyl reductases has not been well understood. The stereo-selectivity is not only determined by the structures of enzymes and substrates, but also affected by the reaction conditions such as temperature and reaction medium. Structural anal. coupled with site-directed mutagenesis of stereo-complementary carbonyl reductases readily reveals the key elements of controlling stereo-selectivity in these enzymes. Enzyme-substrate docking and mol. modeling have been engaged to understand the enantio-selectivity diversity of the carbonyl reductase from Sporobolomyces salmonicolor (SSCR), and to guide site-saturation mutagenesis for altering the enantioselectivity of this enzyme. These studies provide valuable information for understanding of how the residues involved in substrate binding affect the orientation of bound substrate, and thus control the reaction stereo-selectivity. The in silico docking-guided semi-rational approach should be a useful methodol. for discovery of new carbonyl reductases.

Pure and Applied Chemistry published new progress about 350-19-6. 350-19-6 belongs to esters-buliding-blocks, auxiliary class Fluoride,Benzene,Ester, name is Ethyl 3,5-difluorobenzoate, and the molecular formula is C42H63O3P, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Guodong published the artcileRhodium-Catalyzed Annelation of Benzoic Acids with α,β-Unsaturated Ketones with Cleavage of C-H, CO-OH, and C-C Bonds, Related Products of esters-buliding-blocks, the publication is Angewandte Chemie, International Edition (2019), 58(19), 6435-6439, database is CAplus and MEDLINE.

In the presence of a [Cp*RhCl₂]₂ catalyst, the Lewis acid In(OTf)₃, and the mild base Na₂CO₃, aromatic carboxylates and α,β-unsaturated ketones undergo a unique hydroarylation/Claisen/retro-Claisen process to give the corresponding indanones. In this carboxylate-directed ortho-C-H annelation, the C-COR bond of the ketone and the CO-OH group of the aromatic carboxylate are cleaved, and the hydroxy group is transferred from the aromatic to the aliphatic acyl residue. This reactivity is synthetically useful, particularly when starting from cyclic ketones, which are converted into indanones bearing aliphatic carboxylate side chains, thus greatly increasing the mol. complexity of aromatic carboxylates in a single step.

Angewandte Chemie, International Edition published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C12H16O3, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hu, Xiao-Qiang published the artcileCarboxylate-directed C-H allylation with allyl alcohols or ethers, Formula: C9H8O4, the publication is Chemical Science (2018), 9(23), 5289-5294, database is CAplus and MEDLINE.

A [Ru(p-cymene)Cl₂]₂ catalyst activated allyl alcs. and ethers for the regioselective ortho-C-H allylation of aromatic and heteroaromatic carboxylates. The reaction was orthogonal to most C-H functionalizations with allyl alcs. in that allyl arenes rather than carbonyl compounds were obtained. A wide range of substrates were thus smoothly transformed to allylarenes at 50 ° in phosphate-buffered 2,2,2-trichloroethanol. The reaction concept combined the use of abundant reagents and directing groups in a sustainable, waste-minimized method for C-C bond formation.

Chemical Science published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Abbas, Zaheer published the artcileChiral ferrocene/indole-based diphosphine ligands for Rh-catalyzed asymmetric hydrogenation of functionalized olefins, HPLC of Formula: 617-52-7, the publication is Tetrahedron Letters (2020), 61(20), 151860, database is CAplus.

Convenient synthesis of a new family of chiral ferrocene/indole-based diphosphine ligands, (Rc,Rp)-IndoFerroPhos (L), from (Sc,Rp)-PPFA and 2-(diphenylphosphino)indole has been described. These new ligands exhibited high efficiency in the Rh-catalyzed asym. hydrogenation of functionalized olefins including α-dehydroamino acid esters, α-enamides and di-Me itaconate, in which up to >99% yield and 98% ee were achieved.

Tetrahedron Letters published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, HPLC of Formula: 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hu, Zhiyong published the artcileRing-Opening Ortho-C-H Allylation of Benzoic Acids with Vinylcyclopropanes: Merging Catalytic C-H and C-C Activation Concepts, Synthetic Route of 1877-71-0, the publication is Organic Letters (2019), 21(17), 6770-6773, database is CAplus and MEDLINE.

A Ru-catalyzed selective and atom-economic ortho-C-H allylation of aromatic acids with vinylcyclopropanes is reported. The reaction proceeds with selective cleavage of both a C-H and a C-C bond. A wide range of allylarenes were synthesized in high yields and stereoselectivities. The vinylcyclopropane substrates can optionally be generated in situ from a diazo compound and 1,3-butadiene. Concise syntheses of isocoumarin and 3,4-dihydroisocoumarin derivatives underline the synthetic utility of the reaction.

Organic Letters published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Synthetic Route of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Song, Renyuan published the artcileMolecularly imprinted solid-phase extraction of glutathione from urine samples, SDS of cas: 3052-61-7, the publication is Materials Science & Engineering, C: Materials for Biological Applications (2014), 69-75, database is CAplus and MEDLINE.

Molecularly imprinted polymer (MIP) particles for glutathione were synthesized through iniferter-controlled living radical precipitation polymerization (IRPP) under UV radiation at ambient temperature Static adsorption, solid-phase extraction, and high-performance liquid chromatog. were carried out to evaluate the adsorption properties and selective recognition characteristics of the polymers for glutathione and its structural analogs. The obtained IRPP-MIP particles exhibited a regularly spherical shape, rapid binding kinetics, high imprinting factor, and high selectivity compared with the MIP particles prepared using traditional free-radical precipitation polymerization The selective separation and enrichment of glutathione from the mixture of glycyl-glycine and glutathione disulfide could be achieved on the IRPP-MIP cartridge. The recoveries of glutathione, glycyl-glycine, and glutathione disulfide were 95.6% ± 3.65%, 29.5% ± 1.26%, and 49.9% ± 1.71%, resp. The detection limit (S/N = 3) of glutathione was 0.5 mg·L^– 1. The relative standard deviations (RSDs) for 10 replicate detections of 50 mg·L^– 1 of glutathione were 5.76%, and the linear range of the calibration curve was 0.5 mg·L^– 1 to 200 mg·L^– 1 under optimized conditions. The proposed approach was successfully applied to determine glutathione in spiked human urine samples with recoveries of 90.24% to 96.20% and RSDs of 0.48% to 5.67%.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C17H14O5, SDS of cas: 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics