Month: December 2022

Ishiyama, Tatsuo published the artcileOrtho-C-H borylation of benzoate esters with bis(pinacolato)diboron catalyzed by iridium-phosphine complexes, Quality Control of 1146214-86-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(1), 159-161, database is CAplus and MEDLINE.

Iridium complexes generated from [Ir(OMe)(COD)]₂ and tris[3,5-bis(trifluoromethyl)phenyl]phosphine efficiently catalyzed the ortho-C-H borylation of benzoate esters with bis(pinacolato)diboron in octane at 80 °C to produce the corresponding arylboronates in high yields with excellent regioselectivities.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1146214-86-9. 1146214-86-9 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester, name is Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoate, and the molecular formula is C15H18BF3O4, Quality Control of 1146214-86-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Takagi, Daisuke published the artcileManganese toxicity disrupts indole acetic acid homeostasis and suppresses the CO₂ assimilation reaction in rice leaves, SDS of cas: 121-79-9, the publication is Scientific Reports (2021), 11(1), 20922, database is CAplus and MEDLINE.

Despite the essentiality of Mn in terrestrial plants, its excessive accumulation in plant tissues can cause growth defects, known as Mn toxicity. Mn toxicity can be classified into apoplastic and symplastic types depending on its onset. Symplastic Mn toxicity is hypothesised to be more critical for growth defects. However, details of the relationship between growth defects and symplastic Mn toxicity remain elusive. In this study, we aimed to elucidate the mol. mechanisms underlying symplastic Mn toxicity in rice plants. We found that under excess Mn conditions, CO2 assimilation was inhibited by stomatal closure, and both carbon anabolic and catabolic activities were decreased. In addition to stomatal dysfunction, stomatal and leaf anatomical development were also altered by excess Mn accumulation. Furthermore, indole acetic acid (IAA) concentration was decreased, and auxin-responsive gene expression analyses showed IAA-deficient symptoms in leaves due to excess Mn accumulation. These results suggest that excessive Mn accumulation causes IAA deficiency, and low IAA concentrations suppress plant growth by suppressing stomatal opening and leaf anatomical development for efficient CO2 assimilation in leaves.

Scientific Reports published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C24H26ClNO4, SDS of cas: 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Suzuki, Takanori published the artcileMulti-Input/Multi-Output Molecular Response System Based on the Dynamic Redox Behavior of 3,3,4,4-Tetraaryldihydro[5]helicene Derivatives: Reversible Formation/Destruction of Chiral Fluorophore and Modulation of Chiroptical Properties by Solvent Polarity, HPLC of Formula: 126613-06-7, the publication is Chemistry – A European Journal (2009), 15(37), 9434-9441, S9434/1-S9434/20, database is CAplus and MEDLINE.

3,3,4,4-Tetaaryldihydro[5]helicenes (1, I; R = OC_nH_2n+1) and 1,1′-binaphthyl-2,2′-diylbis(diarylcarbenium)s (2²⁺, II) can be reversibly interconverted upon electron transfer, which is accompanied by a vivid color change (electrochromism) as well as by the formation/cleavage of a C-C bond (“dynamic redox behavior”). Because only the neutral donor 1 exhibits strong fluorescence, electrochem. input can further modify the fluorescent properties of the pair. Due to the configurational stability of the helicity in 1 and axial chirality in 2²⁺, the redox reaction of optically pure material proceeds stereospecifically, which induces a chiroptical change such as CD as an addnl. output. The CD spectra of dications 2²⁺ exhibit solvent dependency (chiro-solvatochromism), which is accompanied by solvatochromic behavior based on the π-π interaction of the two cationic chromophores as well as coordinative interaction of the Lewis basic solvent to the Lewis acidic triarylcarbenium moieties. Thus, the present system is endowed with multi-input functionality for modifying multiple output signals.

Chemistry – A European Journal published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C4H3Cl2N3, HPLC of Formula: 126613-06-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kurkcuoglu, M. published the artcileComposition and antimicrobial activity of the essential oils of Calamintha betulifolia Boiss. et Bal, Recommanded Product: Isobutyl palmitate, the publication is Journal of Essential Oil Research (2007), 19(3), 285-287, database is CAplus.

The water distilled essentials oil from the aerial parts of Calamintha betulifolia Boiss. et Bal. collected from three different localities in Turkey were analyzed by GC and GC/MS. Fifty six to seventy nine components representing 80.6-93.0% of the oils were characterized. Pulegone (26-54%) was found as the main constituent. The antimicrobial effects of C. betulifolia essential oil are reported here for the first time.

Journal of Essential Oil Research published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Recommanded Product: Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sohail, Aaqib published the artcileItaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection, Quality Control of 617-52-7, the publication is PLoS Pathogens (2022), 18(1), e1010219, database is CAplus and MEDLINE.

Excessive inflammation is a major cause of morbidity and mortality in many viral infections including influenza. Therefore, there is a need for therapeutic interventions that dampen and redirect inflammatory responses and, ideally, exert antiviral effects. Itaconate is an immunomodulatory metabolite which also reprograms cell metabolism and inflammatory responses when applied exogenously. We evaluated effects of endogenous itaconate and exogenous application of itaconate and its variants dimethyl- and 4-octyl-itaconate (DI, 4OI) on host responses to influenza A virus (IAV). Infection induced expression of ACOD1, the enzyme catalyzing itaconate synthesis, in monocytes and macrophages, which correlated with viral replication and was abrogated by DI and 4OI treatment. In IAV-infected mice, pulmonary inflammation and weight loss were greater in Acod1-/- than in wild-type mice, and DI treatment reduced pulmonary inflammation and mortality. The compounds reversed infection-triggered interferon responses and modulated inflammation in human cells supporting non-productive and productive infection, in peripheral blood mononuclear cells, and in human lung tissue. All three itaconates reduced ROS levels and STAT1 phosphorylation, whereas AKT phosphorylation was reduced by 4OI and DI but increased by itaconate. Single-cell RNA sequencing identified monocytes as the main target of infection and the exclusive source of ACOD1 mRNA in peripheral blood. DI treatment silenced IFN-responses predominantly in monocytes, but also in lymphocytes and natural killer cells. Ectopic synthesis of itaconate in A549 cells, which do not physiol. express ACOD1, reduced infection-driven inflammation, and DI reduced IAV- and IFNγ-induced CXCL10 expression in murine macrophages independent of the presence of endogenous ACOD1. The compounds differed greatly in their effects on cellular gene homeostasis and released cytokines/chemokines, but all three markedly reduced release of the pro-inflammatory chemokines CXCL10 (IP-10) and CCL2 (MCP-1). Viral replication did not increase under treatment despite the dramatically repressed IFN responses. In fact, 4OI strongly inhibited viral transcription in peripheral blood mononuclear cells, and the compounds reduced viral titers (4OI>Ita>DI) in A549 cells whereas viral transcription was unaffected. Taken together, these results reveal itaconates as immunomodulatory and antiviral interventions for influenza virus infection.

PLoS Pathogens published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C12H15NO, Quality Control of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Aitken, R. Alan published the artcileThe X-ray Structures of (R)-2,2′-Dimethyl-1,1′-binaphthyl and (±)-2-Bromomethyl-2′-dibromomethyl-1,1′-binaphthyl, Related Products of esters-buliding-blocks, the publication is Journal of Chemical Crystallography (2021), 51(4), 497-504, database is CAplus.

Mol. structures of (R)-2,2′-dimethyl-1,1′-binaphthyl, I [monoclinic, a = 11.24420 (11), b = 10.56190 (9), c = 13.27180 (13) Å, β = 90.7041 (9)°, space group P21] and (±)-2-bromomethyl-2′-dibromomethyl-1,1′-binaphthyl II [triclinic, a = 9.4637 (14), b = 9.9721 (18), c = 9.9922 (19) Å, α = 100.093 (5), β = 97.141 (5), γ = 92.585 (4)°, space group P^-1] was reported.

Journal of Chemical Crystallography published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shinagawa, Yuko published the artcileNew aminopropanediol derivatives as orally available and short-acting calcium-sensing receptor antagonists, Synthetic Route of 115314-17-5, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(12), 3809-3813, database is CAplus and MEDLINE.

Synthesis and structure-activity relationship studies on new aminopropanediol derivatives I (R¹ = Ph, R² = H, Me, H₂C:CHCH₂, t-Bu, cyclopentyl, Ph, etc.; R¹ = 2-pyridyl, 1-naphthyl, 2-naphthyl, R² = Me; etc.) as calcium-sensing receptor antagonists are described. Modification of the phenolic moiety of a calcilytic compound NPS 2143 led to the identification of an orally available compound (R,R)-I (R¹ = 2-MeC₆H₄; R² = cyclopropyl) which demonstrated a rapid and transient stimulation of PTH release in rats.

Bioorganic & Medicinal Chemistry Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C19H14O2, Synthetic Route of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shinagawa, Yuko published the artcileDiscovery of a Potent and Short-Acting Oral Calcilytic with a Pulsatile Secretion of Parathyroid Hormone, Product Details of C9H9NO6S, the publication is ACS Medicinal Chemistry Letters (2011), 2(3), 238-242, database is CAplus and MEDLINE.

Short-acting oral calcilytics, calcium-sensing receptor (CaSR) antagonists, have been considered as alternatives for parathyroid hormone (PTH), an injectable bone anabolic drug used in the treatment of osteoporosis. Previously, we identified aminopropandiol 1, which transiently stimulated endogenous PTH secretion in rats. However, the inhibition of cytochrome P 450 (CYP) 2D6 and the low bioavailability of 1 remain to be solved. Attempts to change the physicochem. properties of the highly lipophilic amine 1 by introduction of a carboxylic acid group as well as further structural modifications led to the discovery of the highly potent biphenylcarboxylic acid 15 (I), with a markedly reduced CYP2D6 inhibition and a significantly improved bioavailability. Compound 15 evoked a rapid and transient elevation of endogenous PTH levels in rats after oral administration in a dose-dependent manner at a dose as low as 1 mg/kg. The PTH secretion pattern correlated with the pharmacokinetic profile and agreed well with that of the exogenous PTH injection which exerts a bone anabolic effect.

ACS Medicinal Chemistry Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C15H12O6, Product Details of C9H9NO6S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vang, Le published the artcileSex Pheromones of Five Olethreutine Species (Lepidoptera: Tortricidae) Associated with the Seedlings and Fruits of Mangrove Plants in the Ryukyu Islands, Japan: Identification and Field Evaluation, Safety of (Z)-Dodec-9-en-1-yl acetate, the publication is Journal of Chemical Ecology (2005), 31(4), 859-878, database is CAplus and MEDLINE.

The sex pheromones of three Cryptophlebia, one Centroxena, and one Eucosma species (Lepidoptera: Olethreutinae) inhabiting mangroves in the Ryukyu Islands, Japan, were studied with coupled gas chromatog.-electroantennog. detection, and GC-mass spectrometry (GC-MS). The larvae of each Cryptophlebia species are specifically associated with viviparous seedlings from one of three mangrove Rhizophoraceae plants. Whereas three EAG-active alc. components, (Z)-8-dodecen-1-ol, (E)-8-dodecen-1-ol, and dodecan-1-ol, in a ratio of 100:12:4, were identified from the pheromone gland extract of female of C. horii (host: Bruguiera gymnorrhiza), two other sibling species produced the corresponding acetates, i.e., (Z)-8-dodecenyl acetate, (E)-8-dodecenyl acetate, and dodecyl acetate, in a 100:2:3 ratio from Cryptophlebia palustris (host: Rhizophora stylosa in Iriomote-jima Island) and in a 100:7:13 ratio from C. amamiana (host: Kandelia candel in Amami-oshima Island). The double bond positions of the monounsaturated components were confirmed by GC-MS analyses of their adducts with di-Me disulfide. On the other hand, the larvae of Centroxena sp. feed on fruits of Sonneratia alba, another mangrove plant in the Sonneratiaceae, and the extract of the female pheromone glands contained (8E,10E)-dodecadienyl acetate and dodecyl acetate in a ratio of 100:5. The double bond position of the diunsatd. compound was confirmed by GC-MS anal. of its adduct with 4-methyl-1,2,4-triazoline-3,5-dione. (E)-9-Dodecenyl acetate was exclusively identified in the pheromone gland extract of Eucosma coniogramma females reared from seedlings of B. gymnorrhiza. Although the roles of minor components were not revealed by field tests, synthetic lures baited with the main pheromone component of each species successfully attracted the target males, confirming that the sex pheromone is one of the most important factors for their reproductive isolation.

Journal of Chemical Ecology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C9H5ClO4S, Safety of (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Umemoto, Nao published the artcileDevelopment of regioselective [2 + 3] cycloaddition reactions of nitrile oxides with alkenes using intramolecular reactions through oxime groups [1], Recommanded Product: Dimethyl fumarate, the publication is Tetrahedron (2022), 132833, database is CAplus.

Nitrile oxides afford 2-isoxazoline heterocycles through [2 + 3] cycloaddition reactions with alkenes. These heterocycles can be converted to useful intermediates, such as β-hydroxy ketones and γ-amino alcs., leading to pharmaceutical and agrochem. compounds However, nitrile oxides directly connected to a carbonyl group show low reactivity owing to the decrease in energy of the dipole HOMO. Furthermore, when dissym. internal alkenes are used, regioselective control is difficult. Herein, authors have designed nitrile oxides bound to alkenes through the oxime group and demonstrated their intramol. [2 + 3] cycloaddition reactions. The desired cycloadducts were obtained in high yields and as single regioisomers. Furthermore, face-selective cycloaddition reactions were achieved by introducing a stereocenter into the linker moiety, affording the desired cycloadducts with good diastereoselectivity.

Tetrahedron published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C12H23N3S, Recommanded Product: Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics