Month: December 2022

Zhang, Sheng published the artcileDimethyl Itaconate Alleviates the Inflammatory Responses of Macrophages in Sepsis, Safety of Dimethyl itaconate, the publication is Inflammation (2021), 44(2), 549-557, database is CAplus and MEDLINE.

Sepsis is an inflammatory disease characterized by dysregulation of inflammation. Macrophage-mediated inflammation has been implicated in the pathophysiol. of sepsis. Itaconate is a metabolite produced in activated macrophages which has anti-inflammatory activities. In the present study, we investigated the potential effects of a cell-permeable itaconate derivative di-Me itaconate on inflammation in sepsis. We established a lipopolysaccharide (LPS)-induced septic mouse model and administered di-Me itaconate to the septic mice. The survival rate, serum level of pro-inflammatory cytokines, and lung pathol. were evaluated. We also administered di-Me itaconate to LPS-treated bone marrow-derived macrophages (BMDMs), and measured the cytokine production and Nrf2 expression. We also evaluated the effects of di-Me itaconate on Nrf2-deficient mice. Administration of di-Me itaconate enhanced survival rate, decreased serum level of TNF-α and IL-6, and ameliorated lung injury in septic mice. Di-Me itaconate also suppressed LPS-induced production of TNF-α, IL-6, and NOS2 in BMDMs. Di-Me itaconate activated Nrf2 and promoted the expression of Nrf2 and its downstream factor HO-1 and NQO-1. The regulatory activities of di-Me itaconate on inflammatory cytokine production, mouse survival rate were abolished in septic Nrf2^-/- mice. Di-Me itaconate suppressed the inflammatory responses of macrophages in sepsis.

Inflammation published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C5H5NO3S, Safety of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gu, Hai-ning published the artcileSynthesis of Gatifloxacin hydrochloride, Computed Properties of 924-99-2, the publication is Zhejiang Daxue Xuebao, Lixueban (2005), 32(1), 66-68, 74, database is CAplus.

Gatifloxacin was prepared from 3-methoxy-2,4,5-triflurobenzoic acid via acylation, followed by coupling with Et N,N-dimethylaminoacrylate, replacement with cyclopropyl amine, after cyclization and hydrolysis, condensation with 2-methylpiperazine, further hydrolysis, and saltification, provided title product with overall yield 441.1%.

Zhejiang Daxue Xuebao, Lixueban published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gu, Hai-ning published the artcileStudy on new process of synthesizing levofloxacin, Safety of Ethyl 3-(dimethylamino)acrylate, the publication is Gaoxiao Huaxue Gongcheng Xuebao (2005), 19(5), 708-711, database is CAplus.

New process for preparing the fluoroquinolone antibacterial drug levofloxacin was described. The object compound was prepared from 2,3,4,5-tetrafluorobenzoic acid, via acyl chlorination, Et N,N-dimethylamino-acrylate coupling, S-(+)-2-aminopropanol displacement, cyclization, hydrolysis, and finally N-methylpiperazine condensation, the total yield is 52.3%. Comparing to the old process conventionally used at present, the application of the new starting material Et N, N-dimethylamino-acrylate can curtail three reaction steps, they are the di-Et malonate condensation, partial hydrolysis decarboxylation and triethylorthoformate condensation. New process has many advantages, such as simple procedure, short reaction period, high optical purity, cheaper raw material, higher yield. So it should have a good prospect for industrial application.

Gaoxiao Huaxue Gongcheng Xuebao published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Safety of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Guan, Xiao-Yang published the artcileChiral sterically congested phosphane-amide bifunctional organocatalysts in asymmetric aza-Morita-Baylis-Hillman reactions of N-sulfonated imines with methyl and ethyl vinyl ketones, Recommanded Product: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), the publication is European Journal of Organic Chemistry (2008), 2150-2155, database is CAplus.

A series of chiral sterically congested phosphane-amide bifunctional Lewis bases have been prepared and their use in asym. aza-Morita-Baylis-Hillman (aza-MBH) reactions of N-sulfonated imines with activated olefins such as Me and Et vinyl ketone has been investigated under mild conditions. The aza-MBH adducts can be obtained in good-to-excellent yields (≤ 98%) and moderate-to-good enantioselectivities (≤ 91 or 93% ee) in dichloromethane at 20° C.

European Journal of Organic Chemistry published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Recommanded Product: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate).

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Ji-tao published the artcileAnalysis of aroma composition of purple sweet potato and rice wine fermented with different yeast starters, Application of Isobutyl palmitate, the publication is Shipin Kexue (Beijing, China) (2014), 35(16), 202-207, database is CAplus.

The aroma components of purple sweet potato and rice wine fermented with three different yeast starters, alc. active dry yeast and Saccharomyces cerevisiae 1383 and 1596 were analyzed. The anal. was carried out using automatic static headspace-solid phase micro-extraction-gas chromatog.-mass spectrometry. Moreover, the effect of mass ratio between purple sweet potato pulp and sacchrified sticky rice pulp on wine quality was studied. The results showed that the best mass ratio between purple sweet potato pulp and sacchrified sticky rice pulp was in the range of 3: 2-1: 1; the aroma of purple sweet potato and rice wine was composed mainly of esters, alcs., aldehydes, ketones, and alkyl vinyl. Totally 73 aroma components were identified, including 55, 54 and 55 components individually observed in the wines fermented with alc. active dry yeast, and Saccharomyces cerevisiae 1383 and 1596, resp., and 38 aroma components were common to the three wines. The most predominant aroma compound in these three wines was pentanol with relative contents of 17.67%, 17.84% and 18.63%, resp.

Shipin Kexue (Beijing, China) published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Application of Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Yanwei published the artcileCobalt-catalyzed carboxylation of aryl and vinyl chlorides with CO₂, Synthetic Route of 1877-71-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(92), 14416-14419, database is CAplus and MEDLINE.

The transition-metal-catalyzed carboxylation of aryl and vinyl chlorides with CO₂ is rarely studied, and has been achieved only with a Ni catalyst or combination of palladium and photoredox. In this work, the cobalt-catalyzed carboxylation of aryl and vinyl chlorides and bromides with CO₂ has been developed. These transformations proceed under mild conditions and exhibit a broad substrate scope, affording the corresponding carboxylic acids in good to high yields.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C23H23ClN2O4, Synthetic Route of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Xixiang published the artcileEffect of the lanthanum and cerium phenylphosphonates on the crystallization and mechanical properties of isotactic polypropylene, Recommanded Product: Tris(2,4-di-tert-butylphenyl) phosphite, the publication is Journal of Polymer Research (2021), 28(4), 124, database is CAplus.

In this article, the lanthanum phenylphosphonates (LaPPA2) and cerium phenylphosphonates (CePPA2) were synthesized and the effect on the crystallization conducts and mech. performances of isotactic polypropylene (iPP) were studied. After adding 0.05wt.% of LaPPA2 and CePPA2, the crystallization temperature enhanced appreciably. The polarized optical microscopy (POM) imagines indicated that the LaPPA2 and CePPA2 could accelerate the crystallization speed and reduce the spherulites sizes significantly. The presence of LaPPA2 and CePPA2 decreased appreciably the non-isothermal crystallization kinetics parameter F(T). Meanwhile, the nucleation efficiency of LaPPA2 and CePPA2 was similar to industrial standard NAs NA-11, HPN20E and HPN68L. In addition, the mech. properties of iPP have been improved by adding LaPPA2 and CePPA2. According to the investigation of nucleated iPP viscoelasticity, it can be confirmed that the CH/π interplay between iPP and the aromatic groups of LaPPA2 and CePPA2 promoted the attachment of iPP helix and following nucleation.

Journal of Polymer Research published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C15H14O, Recommanded Product: Tris(2,4-di-tert-butylphenyl) phosphite.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Shuang published the artcileProtonic ionic liquids as efficient phase-separation catalysts for esterification of trimethylolpropane and acrylic acid, Product Details of C15H20O6, the publication is Journal of Molecular Liquids (2022), 119403, database is CAplus.

Trimethylolpropane acrylate (TMPTA) is becoming an important organic chem. intermediate, but it’s synthesis through the acid-catalyzed esterification of trimethylolpropane and acrylic acid is a challenge due to the poor activity and catalyst separation problems. In this work, a series of 1,3-propanesultone (PS)-functionalized imidazole ionic liquids (ILs) are prepared and evaluated as the acid catalysts for this reaction, including the catalytic performance comparison, optimization of reaction conditions, and the catalytic reusability. The obtained H₂SO₄-based IL ([IMPSH]HSO₄) caused a phase-separation catalytic process (reacted as a homogeneous catalyst, but precipitated at the end of reaction like a heterogeneous catalyst), presenting the best trimethylolpropane conversion (100%) and TMPTA selectivity (86.4%). Such catalytic performance is even better than that of homogeneous H₂SO₄. Moreover, the catalyst can be steadily reused at least four times without obvious change in activity and its structure. The highly efficient and environmentally benign performance of [IMPSH]HSO₄-catalyzed esterification of trimethylolpropane and acrylic acid make it possible to achieve industrial applications.

Journal of Molecular Liquids published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Product Details of C15H20O6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Wengang published the artcileVisible-Light-Induced Selective Defluoroborylation of Polyfluoroarenes, gem-Difluoroalkenes, and Trifluoromethylalkenes, Formula: C5H10O2S, the publication is Angewandte Chemie, International Edition (2020), 59(10), 4009-4016, database is CAplus and MEDLINE.

Fluorinated organoboranes serve as versatile synthetic precursors for the preparation of value-added fluorinated organic compounds Recent progress has been mainly focused on the transition-metal catalyzed defluoroborylation. Herein, we report a photocatalytic defluoroborylation platform through direct B-H activation of N-heterocyclic carbene boranes, through the synergistic merger of a photoredox catalyst and a hydrogen atom transfer catalyst. This atom-economic and operationally simple protocol has enabled defluoroborylation of an extremely broad scope of multifluorinated substrates including polyfluoroarenes, gem-difluoroalkenes, and trifluoromethylalkenes in a highly selective fashion. Intriguingly, the defluoroborylation protocol can be transition-metal free, and the regioselectivity obtained is complementary to the reported transition-metal-catalysis in many cases.

Angewandte Chemie, International Edition published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C4H10OS, Formula: C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yuan, Chuan published the artcileStudy on catalytic pyrolysis mechanism of seaweed polysaccharide monomer, SDS of cas: 517-23-7, the publication is Combustion and Flame (2020), 1-11, database is CAplus.

In this study, L-rhamnose monohydrate (LRM) was used as a model compound of seaweed polysaccharide to study its pyrolysis and catalytic pyrolysis mechanism. Initially, the weight loss curve of LRM was obtained by thermogravimetric anal. The main weight loss temperature was found to be at 350-550°C. Then, the pyrolysis mechanism of LRM was analyzed and verified by macroscopic experiments and mol. simulations. Experiments showed that the bio-oil yield was highest when the temperature reached around 500°C, and the bio-oil contained large amount of furan substances. Finally, the effects of different proportions of catalysts (Mg-Ce/ZSM-5) on bio-oil products were studied, and the catalytic reaction mechanism was discussed.

Combustion and Flame published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C4H3Cl2N3, SDS of cas: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics