Month: December 2022

A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1 was written by van der Vlag, Ramon;Guo, Hao;Hapko, Uladzislau;Eleftheriadis, Nikolaos;Monjas, Leticia;Dekker, Frank J.;Hirsch, Anna K. H.. And the article was included in European Journal of Medicinal Chemistry in 2019.Application of 763-69-9 The following contents are mentioned in the article:

Human 15-lipoxygenase-1 (15-LOX-1) is a mammalian lipoxygenase which plays an important regulatory role in several CNS and inflammatory lung diseases. To further explore the role of this enzyme in drug discovery, novel potent inhibitors with favorable physicochem. properties are required. In order to identify such new inhibitors, we established a combinatorial screening method based on acylhydrazone chem. This represents a novel application of combinatorial chem. focusing on the improvement of physicochem. properties, rather than on potency. This strategy allowed us to efficiently screen 44 reaction mixtures of different hydrazides and our previously reported indole aldehyde core structure, without the need for individual synthesis of all possible combinations of building blocks. Our approach afforded three new inhibitors with IC₅₀ values in the nanomolar range and improved lipophilic ligand efficiency. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Application of 763-69-9).

Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application of 763-69-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Enzyme-inducing effects of salicylate derivatives was written by Goudonnet, Herve;Mounie, Jacques;Bereksi-Reguig, K.;Truchot, Roger. And the article was included in Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales in 1982.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Of the salicylate derivatives examined, salicylic acid  [69-72-7] itself, Me salicylate  [119-36-8], salicylazosulfapyridine  [599-79-1], 4-iodosalicylic acid  [16870-28-3], and acetylsalicylic acid  [50-78-2] appeared not to induce liver microsomal enzymes in rats, while salicylamide (I) [65-45-2] and benorylate (II) [5003-48-5] caused significant induction, and 3,5-diiodosalicylic acid (III) [133-91-5] was an extremely potent inducer. After 3 daily oral 125-mg/kg doses of III, for example, liver microsomal cytochrome P 450 activity was doubled. Structure-activity relations are briefly discussed. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lipase-catalyzed ring-opening copolymerization of macrocycles for diselenide-functionalized long-chain polycarbonate: Synthesis, kinetic process and ROS responsiveness was written by Li, Siqi;Ma, Xiaotong;Li, Ruizhi;Sun, Chuanhao;Hu, Jieni;Zhang, Yan. And the article was included in Reactive & Functional Polymers in 2022.Reference of 102-09-0 The following contents are mentioned in the article:

Herein, the lipase-catalyzed ring-opening copolymerization of the diethylene diselenide carbonate dimer (SeC) with its analog macrocycle (1,3,12,14-Tetraoxacyclodocosane-2,13-dione, TDC) was explored, and the small-ring carbonate (TMC) was used as control. The structure and composition of the diselenide-functionalized long-chain polycarbonates were confirmed by NMR and FTIR. The ¹³C NMR and ⁷⁷Se NMR showed that the copolymers observed random sequence. Moreover, the kinetic process of TDC + SeC copolymerization demonstrated a faster polymerization rate and higher conversion of SeC in comparison with TMC + SeC. Besides, the copolymers exhibited ROS-responsive behaviors when exposed to the oxidizing environment owing to the diselenide groups, which was confirmed by UV-vis, DLS and TEM. Therefore, the ROS responsiveness facilitated potential application for the diselenide-functionalized copolymers. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Reference of 102-09-0).

Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 102-09-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Interior air pollution in automotive cabins by volatile organic compounds diffusing from interior materials: I. Survey of 101 types of Japanese domestically produced cars for private use was written by Yoshida, Toshiaki;Matsunaga, Ichiro;Tomioka, Kimiko;Kumagai, Shinji. And the article was included in Indoor and Built Environment in 2006.Electric Literature of C7H14O3 The following contents are mentioned in the article:

The types and concentrations of organic compounds in the interior air of 101 different types of Japanese domestically produced private-use cars were examined All the vehicles had been registered in the summer season as new cars and were <3 years old. The airborne compounds in the cabins were collected for 24 h under static condition with the engine stopped and the windows, doors, and vents closed. A total of 275 organic compounds, including many aliphatic hydrocarbons and aromatic hydrocarbons, were identified, and 242 of them could be quantitated for each cabin. The sum of the concentrations of 241 compounds excluding formaldehyde was approx. 600 μg/m^-3 as a median, ranging 136-3968 μg/m^-3 for the tested cars. The findings demonstrated that the air in the cabin of these cars was contaminated by high concentrations of a large variety of organic compound diffusing from the interior materials. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Electric Literature of C7H14O3).

Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Electric Literature of C7H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amphiphilic Star-Shaped Calix[4]resorcinarene as Stationary Phase for Capillary Gas Chromatography was written by Sun, Tao;Li, Bin;Li, Yan;Zhao, Xinyu;Song, Qianqian;Jiang, Xingxing;Shuai, Xiaomin;Li, Youyang;Cai, Zhiqiang;Hu, Shaoqiang. And the article was included in Chromatographia in 2019.Product Details of 106-73-0 The following contents are mentioned in the article:

This work describes the separation performance of the amphiphilic star-shaped calix[4]resorcinarene (C4A-CL)(I) as the stationary phase for capillary gas chromatog. (GC). The statically coated C4A-CL capillary column exhibited medium polarity and high column efficiency of 3877 plates m^-1 determined by naphthalene at 120 °C. Importantly, the C4A-CL column exhibited extremely high resolving capability for aliphatic analytes with varying polarity, including n-alkanes, esters, ketones, alcs., and bromoalkanes. In addition, the C4A-CL column exhibited high selectivity and resolving capability for positional, structural and cis-/trans-isomers. Among them, the C4A-CL column displayed advantageous resolving capability over the com. DB-17 column for aromatic amine isomers. Moreover, it was applied for the determination of isomer impurities in real samples, showing good potential in GC applications. This study involved multiple reactions and reactants, such as Methyl heptanoate (cas: 106-73-0Product Details of 106-73-0).

Methyl heptanoate (cas: 106-73-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 106-73-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Upcycling of dynamic thiourea thermoset polymers by intrinsic chemical strengthening was written by Feng, Haijun;Zheng, Ning;Peng, Wenjun;Ni, Chujun;Song, Huijie;Zhao, Qian;Xie, Tao. And the article was included in Nature Communications in 2022.Quality Control of Isopropylisothiocyanate The following contents are mentioned in the article:

Thermoset polymers are indispensable but their environmental impact has been an ever-increasing concern given their typical intractability. Although concepts enabling their reprocessing have been demonstrated, their practical potential is limited by the deteriorated performance of the reprocessed materials. Here, we report a thiourea based thermoset elastomer that can be reprocessed with enhanced mech. properties. We reveal that the thiourea bonds are dynamic which leads to the reprocessibility. More importantly, they can undergo selective oxidation during high temperature reprocessing, resulting in significant chem. strengthening within certain reprocessing cycles. This is opposite to most polymers for which reprocessing typically results in material deterioration. The possibility of having materials with inherent reprocessing induced performance enhancement points to a promising direction towards polymer recycling. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Quality Control of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Upcycling of dynamic thiourea thermoset polymers by intrinsic chemical strengthening was written by Feng, Haijun;Zheng, Ning;Peng, Wenjun;Ni, Chujun;Song, Huijie;Zhao, Qian;Xie, Tao. And the article was included in Nature Communications in 2022.Recommanded Product: Isopropylisothiocyanate The following contents are mentioned in the article:

Thermoset polymers are indispensable but their environmental impact has been an ever-increasing concern given their typical intractability. Although concepts enabling their reprocessing have been demonstrated, their practical potential is limited by the deteriorated performance of the reprocessed materials. Here, we report a thiourea based thermoset elastomer that can be reprocessed with enhanced mech. properties. We reveal that the thiourea bonds are dynamic which leads to the reprocessibility. More importantly, they can undergo selective oxidation during high temperature reprocessing, resulting in significant chem. strengthening within certain reprocessing cycles. This is opposite to most polymers for which reprocessing typically results in material deterioration. The possibility of having materials with inherent reprocessing induced performance enhancement points to a promising direction towards polymer recycling. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Corresponding States Method for Estimation of Upper Flammability Limit Temperature of Chemical Compounds was written by Gharagheizi, Farhad;Ilani-Kashkouli, Poorandokht;Mohammadi, Amir H.. And the article was included in Industrial & Engineering Chemistry Research in 2012.Product Details of 763-69-9 The following contents are mentioned in the article:

The accuracy and predictability of predictive methods to determine chem. species flammability characteristics are critically important in the chem. industry. This work continued applying the gene expression programming math. strategy to modify existing thermophys. property correlations available in the literature to: optimize the number of independent parameters; amplify the generality; and improve accuracy and predictability. This work presented a simple corresponding states model to predict the upper flammability limit temperature for 1462 organic compounds from 76 chem. families. Correlation parameters included critical temperature and compound acentric factor. Obtained statistical parameters including average absolute relative deviation of results from the DIPPR 801 database values (1.7, 1.8, and 1.7% for training, optimization, and prediction sets, resp.) demonstrated improved accuracy of presented correlations. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Product Details of 763-69-9).

Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 763-69-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Highly Enantioselective Addition of Dialkylzinc to Trifluoroacetophenones, Catalyzed by 1,2-Diamines. Synthesis of Key Fragments of Inhibitors of the Enzyme 11β-HSD1 and Kinetic Analysis of the Process was written by Genov, Miroslav;Martinez-Ilarduya, Jesus M.;Calvillo-Barahona, Mercedes;Espinet, Pablo. And the article was included in Organometallics in 2010.Recommanded Product: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate The following contents are mentioned in the article:

Chiral diamines derived from (R,R)- or (S,S)-1,2-diphenylethylenediamine and (S)- or (R)-2,2′-bis(bromomethyl)-1,1′-binaphthalene perform very well as catalysts in the enantioselective addition of ZnEt₂ and ZnMe₂ to trifluoroacetophenones, avoiding reduction products, in contrast to the poor results with amino alcs. Excellent yields (up to 99%) and high enantioselectivity (up to 92%) are achieved with the best ligands. A kinetic study at low temperature (-37°) shows that the reduction reaction rate on ligandless ZnEt₂ is negligible (2 orders of magnitude slower) compared to the rate of addition reaction on [ZnR₂(N-N)]. Using this new procedure, reported fragments of inhibitors of enzyme 11β-HSD1 that are active against obesity and type 2 diabetes mellitus, as well as new unreported modified fragments of these bioactive mols., were produced efficiently and enantioselectively. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Recommanded Product: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Analgesic and antiinflammatory properties of some new salicylic acid derivatives, including QSAR was written by Langner, A.;Hagen, V.;Labes, D.;Krause, E.. And the article was included in Agents and Actions Supplements in 1982.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Results from analgesic (hot-plate and radiant-heat methods) and antiinflammatory (carrageenin rat paw edema) activity screening in 21 salicylates showed that only 4 compounds [acetylsalicylic acid piperidide, pyrrolidide (I), p-hydroxyanilide [19065-81-7], and 2-pyrimidylamide [71924-69-1] derivatives] had analgesic activity comparable to that of acetylsalicylic acid and only 4 (I and the acetylsalicylic acid p-nitranilide  [25671-41-4], α-pyridylamide, and 2-nitro-4-methoxyanilide [36930-83-3] derivatives) had antiinflammatory activity comparable to that of salicylamide. The remaining substances were either weakly active or inactive. Hansch anal. was performed on a selected number of the substances and the results are discussed in relation to structural requirements for activity. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics