Month: December 2022

Ushigoe, Yoshihiro published the artcileSynthesis of 1,2,4-trioxanes and 1,2,4-trioxepanes by N-halogenosuccinimide-mediated cyclizations of unsaturated hydroperoxyacetals, COA of Formula: C12H14O2, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1997), 5-10, database is CAplus.

Ozonolyses of vinyl ethers R¹R²C:CHOMe [R¹ = Ph, C₇H₁₅, R² = H; R¹R² = (CH₂)₅] in CH₂Cl₂ in the presence of allylic and homoallylic alcs. R⁴₂C:CR³CH₂OH (R³ = Me, H, R⁴ = H, Me) and H₂C:CMeCH₂CH₂OH give in each case the corresponding unsaturated hydroperoxy acetals R⁴₂C:CR³CH₂OCR¹R²OOH and H₂C:CMeCH₂CH₂OCR¹R²OOH, derived from capture of the carbonyl oxides by the unsaturated alcs. N-Halosuccinimide-mediated cyclizations of the hydroperoxides give the corresponding 1,2,4-trioxanes, e.g., I and/or 1,2,4-trioxepanes, e.g., II (X = Br, iodo), depending on the structure of the hydroperoxides and the identity of the N-halosuccinimides.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C17H14N2O2, COA of Formula: C12H14O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Watanabe, Junji published the artcileBioconjugate polymer by photo-iniferter approach: Hydrophilic random or block copolymer-coated surface, Application of Benzyl diethylcarbamodithioate, the publication is Materials Science & Engineering, C: Materials for Biological Applications (2009), 29(7), 2287-2293, database is CAplus.

The fabrication of a high-performance polymer material is important, since it would have the potential of being utilized as a highly effective platform for bioconjugation. In the present study, hydrophilic random or block polymers were designed by a photo-iniferter approach. As typical monomers, Bu methacrylate (BMA) and acrylic acid (AA) were selected to prepare a surface modifier on a substrate. As surface modifiers, the monomers were copolymerized in block and random sequences, and the resulting polymer-coated surfaces were compared in terms of surface wettability and the bioconjugation of the fluorescence-labeled protein. The most favorable characteristic of the resulting polymers was that they offered a dual function: the stability of the adsorbed polymer layer and bioconjugation via functional groups. In the present study, the authors focused on the phys. properties of the polymer-coated surface. Bioconjugation and cell viability were also evaluated.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C8H6BrF3S, Application of Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hoshino, Koji published the artcileIon-conductive liquid crystals: formation of stable smectic semi-bilayers by the introduction of perfluoroalkyl moieties, Application of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Macromolecular Chemistry and Physics (2002), 203(10/11), 1547-1555, database is CAplus.

Two liquid-crystalline compounds having perfluoroalkyl-terminated mesogens at both ends of poly-(ethylene oxide) chains have been prepared These compounds show smectic A (S_A) and C phases over 100°C. The S_A-Iso (isotropic) transition temperatures are higher by about 70°C than those of the two corresponding alkyl-substituted compounds The incorporation of lithium triflate into the perfluoroalkyl-terminated mesogen-containing compounds widens the temperature ranges of the S_A phases for the resulting complexes. The complexes of these compounds containing 50 mol-% of lithium triflate exhibit columnar phases. The ionic conductivities of the homotropically aligned complexes based on fluoroalkyl-terminated compounds along the direction perpendicular to the mol. director of the S_A phases are higher than those of the corresponding compound containing alkyl groups. The increase of the ionic conductivities as well as the stabilization of the smectic phases for these perfluoroalkyl-terminated compounds may be due to the formation of more stabilized layered structures through the intermol. interactions among the perfluoroalkyl moieties.

Macromolecular Chemistry and Physics published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Application of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ali, Mohammad Asif published the artcileHigh-Performance BioNylons from Itaconic and Amino Acids with Pepsin Degradability, SDS of cas: 617-52-7, the publication is Advanced Sustainable Systems (2022), 6(2), 2100052, database is CAplus.

The use of renewable feedstock for polymers has led to poor thermomech. properties with high production costs. Herein, the production of novel chiral dicarboxylic acids derived from renewable itaconic and amino acids (D- or L-leucine) is reported. In this study, rigid chiral heterocyclic dicarboxylic acid monomers are obtained with high purity from itaconic acid-derived di-Me itaconate as a starting material. Chirally interactive polyamides are prepared via melt polycondensation of hexamethylenediamine with heterocyclic diacid monomers. Further studies are conducted on D- or L-leucine-derived polyamides with homochirality that are fully amorphous. In contrast, the crystallization degree of the composite of D-leucine-derived polymer chains with L-leucine-derived chains increases to 36%, presumably due to enhanced interaction between polymer chains with different chiralities. The chirally-interacting composite shows a glass transition temperature, T_g, of approx. 117°C and a melting temperature, T_m, of approx. 213°C, which are higher than those of conventional polyamides such as polyamide 11 (T_g of approx. 57°C). The composite also shows high Young’s moduli, E, and mech. strengths σ, ranging from 2.2-3.8 GPa and 86-108 MPa, resp. In addition, the polyamides show degradability with a digestive enzyme, pepsin.

Advanced Sustainable Systems published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, SDS of cas: 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Seki, Toshimi published the artcileStudies on agents with vasodilator and β-blocking activities. V. Synthesis and pharmacological activity of the optical isomers of TZC-5665, SDS of cas: 115314-17-5, the publication is Chemical & Pharmaceutical Bulletin (1998), 46(1), 84-96, database is CAplus and MEDLINE.

Synthesis of the four optical isomers of TZC-5665, a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinones with chiral glycidyl ethers. The hypotensive and β-blocking activities of TZC-5665 and its optical isomers were examined when given i.v. into anesthetized rats. Furthermore these compounds were evaluated for inhibitory activity on cAMP phosphodiesterase III.

Chemical & Pharmaceutical Bulletin published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C8H10S, SDS of cas: 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Payne, Jack M. published the artcileVersatile Chemical Recycling Strategies: Value-Added Chemicals from Polyester and Polycarbonate Waste, Related Products of esters-buliding-blocks, the publication is ChemSusChem (2022), 15(8), e202200255, database is CAplus and MEDLINE.

Zn^II-complexes bearing half-salan ligands were exploited in the mild and selective chem. upcycling of various com. polyesters and polycarbonates. Remarkably, we report the first example of discrete metal-mediated poly(bisphenol A carbonate) (BPA-PC) methanolysis being appreciably active at room temperature Indeed, Zn(2)₂ and Zn(2)Et achieved complete BPA-PC consumption within 12-18 mins in 2-Me-THF, noting high bisphenol A (BPA) yields (S_BPA=85-91%) within 2-4 h. Further kinetic anal. found such catalysts to possess k_app values of 0.28±0.040 and 0.47±0.049 min^-1 resp. at 4 wt%, the highest reported to date. A completely circular upcycling approach to plastic waste was demonstrated through the production of several renewable poly(ester-amide)s (PEAs), based on a terephthalamide monomer derived from bottle-grade poly(ethylene terephthalate) (PET), which exhibited excellent thermal properties.

ChemSusChem published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bossart, Jonas published the artcileReal-world disease-modifying therapy usage in persons with relapsing-remitting multiple sclerosis: Cross-sectional data from the Swiss Multiple Sclerosis Registry, Quality Control of 624-49-7, the publication is Multiple Sclerosis and Related Disorders (2022), 103706, database is CAplus and MEDLINE.

Several disease-modifying therapies (DMTs), covering a broad spectrum of mechanisms of action, have been approved by regulatory agencies for the treatment of relapsing-remitting multiple sclerosis (RRMS). However, only little is known about the current real-world treatment situation in Switzerland. Based on data from a diverse population of 668 persons with RRMS from the Swiss Multiple Sclerosis Registry (SMSR), the present study aims to fill this gap with a descriptive, cross-sectional approach. Data originated from the SMSR baseline questionnaire and follow-up surveys. Data on current health status and life situation in the last 6 mo were extracted from the survey distributed throughout 2020 and 2021, while data on disease-modifying therapy (DMT) histories were included from preceding surveys. Initially, data was stratified into three DMT groups according to the current DMT status (NO (No DMT), CONTINUED (DMT started more than 6 mo ago), and NEW (DMT started less than 6 mo ago)). In a subsequent anal., the sample was stratified into groups corresponding to the five most frequently prescribed DMTs. Self-reported outcomes including therapy discontinuation or interruption, relapses and side-effects in the last 6 mo were analyzed per group. Life and health situation parameters were also determined and analyzed. The study population consisted of 445 (66.6%) individuals belonging to the CONTINUED, 84 (12.6%) to the NEW, and 139 (20.8%) to the NO group. Within the NO group, 24 (17.3%) reported relapses. Furthermore, self-reported relapses (28 (33.3%)), side-effects (39 (46.4%)), and treatment discontinuations or interruptions (30 (35.7%)) occurred more frequently in the NEW compared to the CONTINUED group (37 (8.3%), 125 (28.1%), 8 (1.8%), resp.). The three groups also differed with respect to age, time since diagnosis, number of symptoms, DMT history, and health-related quality of life. The five most frequently prescribed DMTs included fingolimod (33.4%), di-Me fumarate (25.0%), ocrelizumab (23.6%), natalizumab (10.6%) and teriflunomide (7.5%). The frequency of self-reported relapses ranged from 9.7% to 13.6%. Notable differences were found in the number of self-reported side-effects, ranging from 9.1% with natalizumab to 56.7% with di-Me fumarate. This cross-sectional anal. suggested that the majority of individuals with RRMS in Switzerland continuously receive tolerable DMT. However, groups not receiving DMT or struggling with side-effects or continued disease worsening while on DMT still persist. It is conceivable that the number of self-reported symptoms indicates the need for more detailed clarification of the DMT characteristics and expectations of treatment outcomes. Injectable DMTs no longer play a major role in the treatment of RRMS in Switzerland and a trend toward an early use of potent drugs is emerging.

Multiple Sclerosis and Related Disorders published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Quality Control of 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chotana, Ghayoor A. published the artcileIridium-catalyzed borylation of thiophenes: versatile, synthetic elaboration founded on selective C-H functionalization, Recommanded Product: Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate, the publication is Tetrahedron (2008), 64(26), 6103-6114, database is CAplus and MEDLINE.

Iridium-catalyzed borylation has been applied to various substituted thiophenes to synthesize poly-functionalized thiophenes in good to excellent yields. Apart from common functionalities compatible with iridium-catalyzed borylations, addnl. functional group tolerance to acyl (COMe) and trimethylsilyl (TMS) groups was also observed High regioselectivities were observed in borylation of 3- and 2,5-di-substituted thiophenes. Electrophilic aromatic C-H/C-Si bromination on thiophene boronate esters is shown to take place without breaking the C-B bond, and one-pot C-H borylation/Suzuki-Miyaura cross-coupling has been accomplished on 2- and 3-borylated thiophenes.

Tetrahedron published new progress about 1040281-86-4. 1040281-86-4 belongs to esters-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ester,Boronate Esters,Boronic Acids,Boronic acid and ester,Boronate Esters,, name is Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate, and the molecular formula is C12H17BO4S, Recommanded Product: Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Petrushkina, E. A. published the artcileCopper-catalyzed cross-coupling of (Z)-allyl phenyl ethers with Grignard compounds in the synthesis of insect pheromones, Product Details of C14H26O2, the publication is Russian Journal of General Chemistry (2008), 78(10), 1897-1899, database is CAplus.

(8Z)-Dodec-8-en-1-yl acetate (pheromone of oriental fruit moth Grapholita molesta) and (9Z)-dodec-9-en-1-yl acetate (pheromone of grape berry moth Paralobesia viteana) containing impurities of isomeric structures were synthesized via copper-catalyzed cross-coupling of (Z)-1-phenoxyhex-2-ene and (Z)-1-phenoxypent-2-ene, resp., with Grignard compounds in the key stage.

Russian Journal of General Chemistry published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Product Details of C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hero, Devid published the artcileFree- and reversible deactivation radical (co)polymerization of isobutylene in water under environmentally benign conditions, COA of Formula: C5H10O2S, the publication is European Polymer Journal (2021), 110336, database is CAplus.

The synthesis of a linear polyisobutylene is achieved for the first time by free radical polymerization The reaction was performed in environmentally friendly conditions, i.e., in an aqueous medium using cyclodextrin solubilizer, around room temperature This mild and straightforward radical polymerization resulted in a predominantly linear polymer with low dispersity. Isobutylene was also copolymerized with acrylamide via this cyclodextrin assisted aqueous free-radical polymerization, leading to new poly(isobutylene-co-acrylamide) amphiphilic copolymers. The feed composition of copolymerization had a huge effect on the composition and, therefore, the resulting copolymers solubility Reversible addition-fragmentation chain transfer radical polymerization (RAFT) of isobutylene was also carried out using a PEG-based sym. macro chain transfer agent. Poly(PEG-b-isobutylene-b-PEG) block-copolymer was formed in this one-pot reaction. This novel polymerization method for isobutylene opens new, environmentally benign routes to produce novel copolymers for various applications.

European Polymer Journal published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, COA of Formula: C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics