Month: December 2022

Xu, Weiping published the artcileFe-Catalyzed Dicarbofunctionalization of Vinylarenes with Alkylsilyl Peroxides and β-Keto Carbonyl Substrates, Related Products of esters-buliding-blocks, the publication is Organic Letters (2022), 24(14), 2641-2645, database is CAplus and MEDLINE.

The formation of two carbon-carbon bonds using vinylarenes with alkylsilyl peroxides and β-keto carbonyl substrates is effected in the presence of catalytic Fe(OTf)₂ under mild reaction conditions. A variety of vinylarenes with different substituents can be utilized in combination with several different alkylsilyl peroxides and β-keto carbonyl substrates.

Organic Letters published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C9H22OSi, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Niitsu, Nozomi published the artcileAnticancer derivative of butyric acid (pivalyloxymethyl butyrate) specifically potentiates the cytotoxicity of doxorubicin and daunorubicin through the suppression of microsomal glycosidic activity, COA of Formula: C10H18O4, the publication is Molecular Pharmacology (2000), 58(1), 27-36, database is CAplus and MEDLINE.

Pivalyloxymethyl butyrate (AN9) is an anticancer derivative of butyric acid. In this study, doxorubicin (DXR) and AN9 synergistically inhibited the growth of lymphoma and lung carcinoma cells, whereas there was no synergy between AN9 and antimetabolites. AN9 did not affect the intracellular uptake of DXR. Among anthracyclines and their derivatives, the synergistic effect was prominent in compounds with a daunosamine moiety, suggesting that AN9 may affect the catabolism of these compounds The degradation of DXR in the extract from AN9-treated cells was much less than that in extract from untreated cells. AN9 did not directly inhibit the enzyme activity but rather suppressed expression of the enzyme. With respect to the expression of drug resistance-related genes, there was no significant difference between untreated and AN9-treated cells. However, AN9 significantly down-regulated the levels NADPH-cytochrome P 450 reductase and DT-diaphorase mRNA in the presence of DXR but not the level of xanthine oxidase mRNA. The enhancement of the sensitivity to anthracyclines was closely associated with the suppression of the mRNA expression.

Molecular Pharmacology published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, COA of Formula: C10H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Honma, Yoshio published the artcileDifferentiation therapy for monocytic leukemia using fatty acid derivatives, Application of (Pivaloyloxy)methyl butyrate, the publication is Recent Research Developments in Lipids Research (1997), 189-198, database is CAplus.

Myeloid leukemia cells can be induced to differentiate terminally into non-dividing mature cells by various compounds, including short chain fatty acids. Many monocytoid leukemia cell lines are relatively sensitive to butyrate and its analogs with regard to the induction of differentiation and inhibition of proliferation of the cells. To develop a novel therapy for monocytic leukemia, we studied the basic issues of differentiation therapy using fatty acid derivatives

Recent Research Developments in Lipids Research published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Application of (Pivaloyloxy)methyl butyrate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kafka, Wolf A. published the artcileEAC and single cell responses of the European corn borer, Ostrinia nubilalis, Z-strain (Hbn) to the sex pheromone components z11-14:Ac, e11-14:Ac, structural analogs and some of their mixtures, Computed Properties of 16974-11-1, the publication is Acta Phytopathologica et Entomologica Hungarica (1989), 24(1-2), 117-24, database is CAplus.

Efficacy values were determined electrophysiol. for the sex-pheromone components Z– and E-tetradecenyl acetate (z11-14:Ac) and about 60 structural analoges and some of their binary mixtures in both sexes of laboratory-reared Z-strain of the European corn borer, O. nubilalis). The efficacy values were defined, on the basis of electroantennogram (EAG) dose response relations, as the ratios of source loads required for the different compounds to elicit a standard EAG-response. The compounds induced no EAG-responses in the females, but, with only small inter- and intra-individual variations, strongly differentiated responses in the males. The efficacy values varied between 1 (for the most effective compound z11-14:Ac) and about 300. Binary mixtures of the highly effective compounds induced EAG-responses which were up to nearly 100% higher than those ones which were induced by merely doubling the individual source loads (EAG enlargement about 30%). Supported by preliminary recordings from single receptor cells within morphol. different types of sensilla trichodea, there are thus indicated at least 5 different types of receptor cells. They respond either to the Z– or to the E-pheromone component (both types were found within one type of sensillum) or to some of the analogs e.g. z11-14:Ac, and a (97:3) mixture of e9- and e9-14:Ac. Responses were also elicited by y11-14:Ac (y stands for acetylenic C-C bonds), but it is still open if e11-14:Ac and y11-14:Ac excite one and the same type of the receptor cell.

Acta Phytopathologica et Entomologica Hungarica published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Computed Properties of 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Hiari, Yusuf M. published the artcileFluoroquinolones: novel class of gastrointestinal dietary lipid digestion and absorption inhibitors, Name: Ethyl 3-(dimethylamino)acrylate, the publication is Medicinal Chemistry Research (2014), 23(7), 3336-3346, database is CAplus.

Pancreatic triacylglycerol lipase (PL) has been reported as an interesting pharmacol. target for the management of dyslipidemia, atherosclerosis, and obesity. In the current study, a 4-quinoline-3-carboxylic acid system has been identified as a potent inhibitor of PL. Three new fluoroquinolones (11, 12, (I) and 13 (II)) were synthesized and evaluated in vitro with respect to their anti-lipase efficacy and potency properties and gave IC₅₀ values in the range of 18.4-29.1 μM against PL. The IC₅₀ of the standard drug orlistat was 0.2 μM. The inhibitory activities of these compounds were supported by docking studies, which suggested that they acted according to a similar mechanism to that of the known drug orlistat. In conclusion, these effective PL inhibitors could be used to advance the development of anti-obesity drugs via the regulation of the entire gastrointestinal lipolysis process.

Medicinal Chemistry Research published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Name: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shengule, Sudhir R. published the artcileDiastereoselective Pictet-Spengler reactions of a tethered 2-aminoimidazole, Formula: C10H19NO3, the publication is Australian Journal of Chemistry (2014), 67(2), 184-191, database is CAplus.

The diastereoselective Pictet-Spengler reaction of aminopropyl-2-aminoimidazole with enantiopure aldehydes was investigated. With amino acid-derived aldehydes, anti-stereochem. was favored, with a diastereoselectivity up to 92% achievable. The absolute stereochem. of the products was determined through synthesis of a rigid derivative and from NMR data in combination with mol. modeling. The diastereoselectivity dependent on the steric bulk of the amino acid side chain and independent of the nitrogen protecting group. Lewis acids catalyzed the reaction but did not affect the diastereoselectivity.

Australian Journal of Chemistry published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C9H9NO, Formula: C10H19NO3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rajmani Singh, Rahul Kumar published the artcileCopper-catalyzed enantioselective direct α-C-H amination of β-dicarbonyl derivatives with aryl hydroxylamines and mechanistic insights, Synthetic Route of 517-23-7, the publication is Molecular Catalysis (2020), 111067, database is CAplus.

Authors report a novel and efficient Cu-catalyzed direct asym. amination of tertiary β-carbonyl compounds using aryl hydroxylamine as electrophilic nitrogen donor. The process facilitates the convenient and direct synthesis of chiral α-amino carbonyl derivatives, without the need for any post-reaction manipulation. This method reveals an effective strategy for the synthesis of enantioenriched α-C-H aminated derivatives which is hitherto challenging. The choice of the robust chiral indabox ligand was ascertained to be very crucial for the desired enantioselectivity in the contemporary transformation. The reaction mechanism is fully supported by ab initio electronic structure calculations The reaction is facile, efficient and performs well at room temperature with an enantiomeric excess (ee) up to 93%.

Molecular Catalysis published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Synthetic Route of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Iliyasov, Taigib M. published the artcileStereoselective one-pot five-component synthesis of polysubstituted 1,4,5,6-tetrahydropyridines with two and three stereocenters, COA of Formula: C6H10O3, the publication is ARKIVOC (Gainesville, FL, United States) (2022), 232-244, database is CAplus.

A novel five-component stereoselective synthesis of polysubstituted tetrahydropyridines is reported. The Knoevenagel condensation – Michael addition – Mannich reaction – cyclization – dehydration cascade of aldehydes, esters of 3-oxocarboxylic acids C-H acids and ammonium acetate provides convenient access to 2-substituted alkyl (4SR,6RS)-4,6-diaryl-5,5-dicyano-1,4,5,6-tetrahydropyridine-3-carboxylates with two stereocenters and 3,5-dialkyl (4RS,5SR,6RS)-5-cyano-2,4,6-triaryl-1,4,5,6-tetrahydropyridine-5,3-carboxylates with three stereocenters in 57-84% yields. It was established that formation of products proceeds via substituted 2-hydroxypiperidines with four stereocenters. Ammonium acetate plays a dual role, acting as a base and as a nitrogen source. Five bonds are formed as a result of multicomponent process. The formation of single diastereomers was confirmed by singe crystal X-ray diffraction studies and 2D-NMR spectroscopy.

ARKIVOC (Gainesville, FL, United States) published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, COA of Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gembus, Vincent published the artcileRegioselective pinacol rearrangement of unsymmetrical cyclobutane-1,2-diols, Application In Synthesis of 517-23-7, the publication is Bulletin of the Chemical Society of Japan (2018), 91(3), 319-336, database is CAplus.

Hydroxy-sulfone I, prepared as a mixture of trans and cis isomers, was found to rearrange selectively either to the cyclopropanic β-ketosulfone II or the isomeric Me ketone III by using, resp., the tosyl fluoride/DBU and the DAST reagent. The potential of this methodol. has been illustrated by a synthesis of phytal from geranylacetone, and by the preparation from 3,4-hexanedione and prenol – via the cyclopropanic β-ketosulfone IV (X-ray) – of an advanced fragment of the juvenile hormone V.

Bulletin of the Chemical Society of Japan published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Application In Synthesis of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jaisingh, Aanchal published the artcileTuning Melt Strength and Processability of Polyolefins by Addition of a Functionalized Additive Designed via the TEMPO-Driven Thiol-ene Reaction, Application of Tris(2,4-di-tert-butylphenyl) phosphite, the publication is Industrial & Engineering Chemistry Research (2021), 60(28), 10155-10166, database is CAplus.

Thiol-ene chem. with TEMPO as an initiator has been utilized to synthesize a first-generation dendrimer having eight peripheral hydroxyl groups. Long chain branched impact copolymer polypropylene (ICP) and linear low-d. polyethylene (LLDPE) were prepared by a postreactor modification process by a melt-grafting dendrimer onto a polyolefin chain using peroxide and maleic anhydride as a co-agent. Long chain branching in ICP controlled the chain scission initiated by peroxide by increasing entanglement, while for LLDPE, it controlled the excessive crosslinking because of peroxide. Neat and modified ICP and LLDPE samples were analyzed by FT-IR, TGA, DSC, HT-GPC, MFI, and parallel-plate rheometry as well as for their melt strength. The presence of long chain branching was mainly confirmed by time-temperature superposition (TTS) anal. obtained using a parallel-plate rheometer. In comparison to neat polymers, modified ICP and LLDPE samples showed higher values of Arrhenius flow activation energy. In the case of ICP, higher processability was observed for a dendrimer-grafted sample, while modified LLDPE samples exhibited higher melt strength as compared to neat polymers. Van Gurp-Palmen plots showed a decrease in phase angle as a function of angular frequency for modified ICP and LLDPE samples, which also confirmed their thermorheol. complex behavior.

Industrial & Engineering Chemistry Research published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C42H63O3P, Application of Tris(2,4-di-tert-butylphenyl) phosphite.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics