Month: December 2022

Schmid, Lucius published the artcilePhotostable Ruthenium(II) Isocyanoborato Luminophores and Their Use in Energy Transfer and Photoredox Catalysis, Related Products of esters-buliding-blocks, the publication is JACS Au (2021), 1(6), 819-832, database is CAplus and MEDLINE.

Ruthenium(II) polypyridine complexes are among the most popular sensitizers in photocatalysis, but they face some severe limitations concerning accessible excited-state energies and photostability that could hamper future applications. In this study, the borylation of heteroleptic ruthenium(II) cyanide complexes with α-diimine ancillary ligands is identified as a useful concept to elevate the energies of photoactive metal-to-ligand charge-transfer (MLCT) states and to obtain unusually photorobust compounds suitable for thermodynamically challenging energy transfer catalysis as well as oxidative and reductive photoredox catalysis. B(C₆F₅)₃ groups attached to the CN^– ligands stabilize the metal-based t_2g-like orbitals by ~0.8 eV, leading to high ³MLCT energies (up to 2.50 eV) that are more typical for cyclometalated iridium(III) complexes. Through variation of their α-diimine ligands, nonradiative excited-state relaxation pathways involving higher-lying metal-centered states can be controlled, and their luminescence quantum yields and MLCT lifetimes can be optimized. These combined properties make the resp. isocyanoborato complexes amenable to photochem. reactions for which common ruthenium(II)-based sensitizers are unsuited, due to a lack of sufficient triplet energy or excited-state redox power. Specifically, this includes photoisomerization reactions, sensitization of nickel-catalyzed cross-couplings, pinacol couplings, and oxidative decarboxylative C-C couplings. Our work is relevant in the greater context of tailoring photoactive coordination compounds to current challenges in synthetic photochem. and solar energy conversion.

JACS Au published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Ding published the artcileRoom-temperature Pd-catalyzed methoxycarbonylation of terminal alkynes with high branched selectivity enabled by bisphosphine-picolinamide ligand, Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(7), 1041-1044, database is CAplus and MEDLINE.

Authors report the room-temperature Pd-catalyzed methoxy-carbonylation with high branched selectivity using a new class of bisphosphine-picolinamide ligands. Systematic optimization of ligand structures and reaction conditions revealed the significance of both the picolinamide and bisphosphine groups in the ligand backbone. This strategic design of ligand was leveraged to deliver various α-substituted acrylates in good to excellent yields.

Chemical Communications (Cambridge, United Kingdom) published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wu, Yinping published the artcileLarge-molecular-weight acyldiphenylphosphine oxides as low-mobility type I photoinitiator for radical polymerization, HPLC of Formula: 15625-89-5, the publication is European Polymer Journal (2022), 111380, database is CAplus.

In recent years, the light source for photopolymerization technol. is evolving from energy-hungry mercury lamps to the safer light-emitting diodes (LEDs), and it is urgent to develop new photoinitiator adapted to the photopolymerization system with LED light source. Some acyldiphenylphosphine oxide photoinitiators have been designed and developed for LED light source, but their application is severely limited in the fields of food packing, medical equipment, environmentally-friendly product, etc. due to their high mobility in photocured polymers. In this study, eight acyldiphenylphosphine oxide mols. (DAPO-1 ∼ DAPO-8) were synthesized by introducing large mol. weight groups and their UV-visible absorption, photodegradation quantum yield, photopolymerization properties, mobility and solubility in monomer were determined Thereinto, photoinitiators show lower mobility than TPO, the photoinitiator commonly used in industry, as well as good solubility in monomers and excellent photopolymerization performance. Therefore, they can serve as potential substitutes for com. TPO, especially in the application of low-migration photocurable system.

European Polymer Journal published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C17H18N3NaO3S, HPLC of Formula: 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Uozumi, Yasuhiro published the artcile(R)-2-diphenylphosphino-2′-methoxy-1,1′-binaphthyl, Quality Control of 126613-06-7, the publication is Organic Syntheses (2002), 1-13, database is CAplus.

The preparation of title compound is described in details, starting from (R)-(+)-1,1′-bi-2-naphthol. (R)-1,1′-binaphthalene-2,2′-ditriflate was coupled with diphenylphosphine oxide under Pd(OAc)₂-dppb catalysis affording (R)-2-diphenylphosphinyl-2′-trfluoromethanesulfonyloxy-1,1′-binaphthalene, then after hydrolysis the MeI etherification gave (R)-2-diphenylphosphinyl-2′-methoxy-1,1′-binaphthalene, which was reduced to the title compound by HSiCl₃.

Organic Syntheses published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C12H14BNO2, Quality Control of 126613-06-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sugie, Hajime published the artcileIdentification of the sex pheromone of the three-spotted plusia, Acanthoplusia agnata Staudinger (Lepidoptera: Noctuidae), Formula: C14H26O2, the publication is Applied Entomology and Zoology (1990), 25(4), 467-73, database is CAplus.

The sex pheromone of the three-spotted plusia, A. agnata, was extracted from abdominal tips of virgin females. The crude extract was purified by Florisil column chromatog., HPLC, and gas chromatog. Male moths were released and captured in a field cage to detect the activity of fractionated samples. The sex pheromone components of A. agnata were estimated to be (Z)-7- and (Z)-9-dodecenyl acetates according to anal. by capillary GC and GC-MS. A plastic, capsule-loaded 1.1 mg of mixture of the 2 compounds in a 10:1 ratio attracted male moths under field conditions. Thus, the sex pheromone of A. agnata was determined to be a 10:1 mixture of (Z)-7- and (Z)-9-dodecenyl acetates. This mixture also attracted male moths of Chrysodeixis eriosoma.

Applied Entomology and Zoology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C5H9IO2, Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Miyauchi, Rie published the artcileDesign, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria, Quality Control of 924-99-2, the publication is Bioorganic & Medicinal Chemistry (2009), 17(19), 6879-6889, database is CAplus and MEDLINE.

A series of novel 6-desfluoro [des-F(6)] and 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methoxyquinolones bearing 3-(1-aminocycloalkyl)pyrrolidin-1-yl substituents at the C-7 position (1-6) was synthesized to obtain potent drugs for nosocomial infections caused by Gram-pos. pathogens. The des-F(6) compounds 4-6 exhibited at least four times more potent activity against representative Gram-pos. bacteria than ciprofloxacin or moxifloxacin. Among the derivatives, 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] derivative 4, which showed favorable profiles in preliminary toxicol. and non-clin. pharmacokinetic studies, exhibited potent antibacterial activity against clin. isolated Gram-pos. pathogens that had become resistant to one or more antibiotics.

Bioorganic & Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Quality Control of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sato, Motohide published the artcileQuinolone Carboxylic Acids as a Novel Monoketo Acid Class of Human Immunodeficiency Virus Type 1 Integrase Inhibitors, SDS of cas: 924-99-2, the publication is Journal of Medicinal Chemistry (2009), 52(15), 4869-4882, database is CAplus and MEDLINE.

The synthesis and detailed structure-activity relationship of quinolonecarboxylic acids as a novel monoketo acid class of HIV-1 integrase inhibitors was presented. Compounds I (R = t-Bu), which showed an IC₅₀ of 5.8 nM in the strand transfer assay and an ED₅₀ of 0.6 nM in the antiviral assay, and I (R = i-Pr), which had an IC₅₀ of 7.2 nM and an ED₅₀ of 0.9 nM, were the most potent compounds in this class. The monoketo acid I (R = i-Pr) was much more potent at inhibiting integrase-catalyzed strand transfer processes than 3′-processing reactions, as is the case with the keto-enol acids. Elvitegravir I (R = i-Pr) was chosen as a candidate for further studies and was reported as being in phase 3 clin. trials.

Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mewshaw, Richard E. published the artcileNew Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D₂ Agonist Pharmacophore. Structure-Activity Relationships of a Series of 2-Aminomethyl Chromans, Related Products of esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (1997), 40(26), 4235-4256, database is CAplus and MEDLINE.

A series of 2-(aminomethyl)chromans (2-AMCs) was synthesized and evaluated for their affinity and selectivity for both the high- and low-affinity agonist states (D₂^High and D₂^Low, resp.) of the dopamine (DA) D₂ receptor. The 7-hydroxy-2-(aminomethyl)chroman moiety was observed to be the primary D₂ agonist pharmacophore. The 2-methylchroman moiety was discovered to be an entirely novel scaffold which could be used to access the D₂ agonist pharmacophore. Attaching various simple alkyl and arylalkyl side chains to the 7-hydroxy 2-AMC nucleus had significant effects on selectivity for the D₂^High receptor vs the 5HT_1A and α₁ receptors. A novel DA partial agonist, (R)-(-)-2-[(benzylamino)methyl]chroman-7-ol was identified as having the highest affinity and best selectivity for the D₂^High receptor vs the α₁ and 5HT_1A receptors. Several regions of the 2-AMC nucleus were modified and recognized as potential sites to modulate the level of intrinsic activity. The global min. conformer of the 7-hydroxy-2-AMC moiety was identified as fulfilling the McDermed model D₂ agonist pharmacophore criteria and was proposed as the D₂ receptor-bound conformation. Structure-activity relationships gained from these studies have aided in the synthesis of D₂ partial agonists of varying intrinsic activity levels. These agents should be of therapeutic value in treating disorders resulting from hypo- and hyperdopaminergic activity, without the side effects associated with complete D₂ agonism or antagonism.

Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Almutairi, Basil published the artcileSynergistic effect of graphene oxide/calcium phosphate nanofiller in a dentin adhesive on its dentin bond integrity and degree of conversion. A scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared, micro-Raman , and bond strength study, Name: Ethyl 4-dimethylaminobenzoate, the publication is Microscopy Research and Technique (2021), 84(9), 2082-2094, database is CAplus and MEDLINE.

The objective was to formulate and analyze a dentin adhesive incorporated with graphene oxide (GO) nanoparticle and calcium phosphate (CaP) composite. Methods comprising of SEM (SEM)-energy dispersive X-ray spectroscopy (EDX), micro-Raman spectroscopy, shear bond strength (SBS), and Fourier transform IR (FTIR) spectroscopy were used to characterize nanoparticle composite, dentin bond toughness, degree of conversion (DC), and adhesive-dentin interaction. Postsynthesis of GO nanoparticles, they were functionalized with CaP using standard process. The GO-CaP composite was not added to exptl. adhesive (neg. control group, GO-CaP-0%), and added at 2.5 and 5 wt% to yield GO-CaP-2.5% and GO-CaP 5% groups, resp. Teeth were set to form bonded samples utilizing adhesives in three groups for SBS testing, with and without thermocycling. The homogenous diffusion of GO-CaP composite was verified in the adhesive. Resin tags having standard penetrations were observed on SEM micrographs. The EDX anal. confirmed the occurrence of calcium, phosphorus, and carbon ions in the composite containing adhesives. The SBS test revealed highest mean values for GO-CaP-5% followed by GO-CaP-2.5%. The FTIR spectra verified the presence of apatite peaks and the micro-Raman spectra showed characteristic D and G bands for GO nanoparticles. GO-CaP composite in dentin adhesive may improve its bond strength. The addition of 5 wt% resulted in a bond strength that was superior to all other groups. GO-CaP-5% group demonstrated lower DC (to control), uniform distribution of GO and CaP composite within adhesive, appropriate dentin interaction, and resin tag formation.

Microscopy Research and Technique published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Name: Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Giannopoulos, Vasileios published the artcileDichlorination of β-Keto Esters and 1,3-Diketones Mediated by Oxone/Aluminum Trichloride Mixture in Aqueous Medium, Quality Control of 30414-53-0, the publication is Synthesis (2022), 54(10), 2457-2463, database is CAplus.

A new method for the α,α-dichlorination of β-keto esters using oxone/aluminum trichloride mixture in aqueous medium had been developed. This useful process had also been applied successfully for the dichlorination of 1,3-diketones. The dichlorinated compds of formula I [R¹ = CH₃, C₂H₅, vinyl, etc.; R² = CH₃, C₂H₅, t-Bu]. had been produced in one step, high yields, and short reaction times.

Synthesis published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Quality Control of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics