Month: December 2022

Shin, Dongha published the artcileGold nanoparticle-mediated non-covalent functionalization of graphene for field-effect transistors, Formula: C6H8O3, the publication is Nanoscale Advances (2021), 3(5), 1404-1412, database is CAplus.

Since its discovery, graphene has attracted much attention due to its unique elec. transport properties that can be applied to high-performance field-effect transistors (FETs). However, mounting chem. functionalities onto graphene inevitably involves the breaking of sp² bonds, resulting in the degradation of the mech. and elec. properties compared to pristine graphene. Here, we report a new strategy to chem. functionalize graphene for use in FETs without affecting the elec. performance. The key idea is to control the Fermi level of the graphene using the consecutive treatment of gold nanoparticles (AuNPs) and thiol-SAM (self-assembled monolayer) mols., inducing pos. and neg. doping effects, resp., by flipping the elec. dipoles between AuNPs and SAMs. Based on this method, we demonstrate a Dirac voltage switcher on a graphene FET using heavy metal ions on functionalized graphene, where the carboxyl functional groups of the mediating SAMs efficiently form complexes with the metal ions and, as a result, the Dirac voltage can be pos. shifted by different charge doping on graphene. We believe that the nanoparticle-mediated SAM functionalization of graphene can pave the way to developing high-performance chem., environmental, and biol. sensors that fully utilize the pristine properties of graphene.

Nanoscale Advances published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C11H20N2O3, Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Narita, Koichi published the artcileTotal Synthesis of the Bicyclic Depsipeptide HDAC Inhibitors Spiruchostatins A and B, 5”-epi-Spiruchostatin B, FK228 (FR901228) and Preliminary Evaluation of Their Biological Activity, Computed Properties of 106391-88-2, the publication is Chemistry – A European Journal (2009), 15(42), 11174-11186, S11174/1-S11174/103, database is CAplus and MEDLINE.

The bicyclic depsipeptide histone deacetylase (HDAC) inhibitors spiruchostatins A and B, 5”-epi-spiruchostatin B and FK228 were efficiently synthesized in a convergent and unified manner. The synthetic method involved the following crucial steps: (i) a Julia-Kocienski olefination of a 1,3-propanediol-derived sulfone and a L- or D-malic acid-derived aldehyde to access the most synthetically challenging unit, (3S or 3R,4E)-3-hydroxy-7-mercaptohept-4-enoic acid, present in a D-alanine- or D-valine-containing segment; (ii) a condensation of a D-valine-D-cysteine- or D-allo-isoleucine-D-cysteine-containing segment with a D-alanine- or D-valine-containing segment to directly assemble the corresponding seco-acids; and (iii) a macrocyclization of a seco-acid using the Shiina method or the Mitsunobu method to construct the requisite 15- or 16-membered macrolactone. The present synthesis has established the C5” stereochem. of spiruchostatin B. In addition, HDAC inhibitory assay and the cell-growth inhibition anal. of the synthesized depsipeptides determined the order of their potency and revealed some novel aspects of structure-activity relationships. It was also found that unnatural 5”-epi-spiruchostatin B shows extremely high selectivity (ca. 1600-fold) for class I HDAC1 (IC₅₀ = 2.4 nM) over class II HDAC6 (IC₅₀ = 3900 nM) with potent cell-growth-inhibitory activity at nanomolar levels of IC₅₀ values.

Chemistry – A European Journal published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Computed Properties of 106391-88-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nishimura, Yoshio published the artcileSynthesis of 6-unsubstituted 2-oxo, 2-thioxo, and 2-amino-3,4-dihydropyrimidines and their antiproliferative effect on HL-60 cells, Computed Properties of 924-99-2, the publication is Tetrahedron Letters (2020), 61(28), 151967, database is CAplus.

A general and efficient synthetic method for 6-unsubstituted 3,4-dihydropyrimidin-2(1H)-thiones and -ones I (R = H, C₆H₅, 4-ClC₆H₄, etc., X = S, O) has been developed. In three-component reactions, the reactivity of reagents serving as the C5-C6 fragment of the dihydropyrimidine ring was compared. The reaction of thiourea or urea, aldehydes RCHO, and Et 3-(dimethylamino)acrylate in the presence of a catalytic amount of AlCl₃ by smooth heating proceeds to give I in high yields. Synthetic novelty of the protocol are as follows: (1) Lewis acid-mediated reaction, (2) good to high yields, and (3) broad scope as for aldehydes and ureas. Hitherto unavailable 6-unsubstituted 2-aminodihydropyridimidines II (R = n-Pr, Ph) have been obtained from the 2-thioxo derivative I (X = S) by a stepwise method involving substitution reaction with the amine at the 2-position. The 6-unsubstituted compounds I and 6-Me derivatives III (R = cyclohexyl, n-Pr) were assessed for their antiproliferative effect on the human promyelocytic leukemia cell line, HL-60. The 4-propyl-6-Me derivative III (R = n-Pr) showed relatively strong activity with the IC₅₀ value of 952 nM.

Tetrahedron Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bernardes, Goncalo J. L. published the artcileDesign, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting, Formula: C14H19NO8, the publication is Organic & Biomolecular Chemistry (2010), 8(21), 4987-4996, database is CAplus and MEDLINE.

Targeting glycan-binding receptors is an attractive strategy for cell-specific drug and gene delivery. The C-type lectin asialo-glycoprotein receptor (ASGPR) is particularly suitable for liver-specific delivery due to its exclusive expression by parenchymal hepatocytes. In this study, we designed and developed an efficient synthesis of carbohydrate-functionalized β-cyclodextrins (βCDs) and liposomes for hepatocyte-specific delivery. For targeting of ASGPR, rhodamine B-loaded βCDs were functionalized with glycodendrimers. Liposomes were equipped with synthetic glycolipids containing a terminal d-GalNAc residue to mediate binding to ASGPR. Uptake studies in the human hepatocellular carcinoma cell line HepG2 demonstrated that βCDs and liposomes displaying terminal d-Gal/d-GalNAc residues were preferentially endocytosed. In contrast, uptake of βCDs and liposomes with terminal d-Man or D-GlcNAc residues was markedly reduced. The d-Gal/d-GalNAc-functionalized βCDs and liposomes presented here enable hepatocyte-specific targeting. Gal-functionalized βCDs are efficient mol. carriers to deliver doxorubicin in vitro into hepatocytes and induce apoptosis.

Organic & Biomolecular Chemistry published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Formula: C14H19NO8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Aubrecht, Jaroslav published the artcileEnhanced activity of Cu/SiO₂ and Cu/ZrO₂ catalysts in dimethyl adipate hydrogenolysis, COA of Formula: C8H14O4, the publication is Catalysis Today, database is CAplus.

According to green chem. principles, the process of ester hydrogenolysis is not sustainable. It is catalyzed by Adkins CuCr₂O₃ catalyst that brings some environmental risks. Therefore, a design of new environmentally-friendly hydrogenolysis catalysts is highly desired. We investigated eight catalysts prepared using two methods – incipient wetness impregnation (IWI) and chemisorption-hydrolysis (CH) – with a combination of two types of supports – ZrO₂ and two types of SiO₂. The preparation method affects significantly the dispersion of the resulting copper phase in case of SiO₂, and CH is essential to obtain very small and active Cu particles. On the other hand, when ZrO₂ is used, the most critical aspect is its sp. surface area, and a highly dispersed copper phase is formed on the high sp. surface area sample, both for CH and IWI preparation methods. All eight prepared catalysts were investigated in di-Me adipate hydrogenolysis to compare their activity and selectivity. Nice correlation between support – synthesis method – activity was found. ZrO₂-based catalysts and CH resulted in more active catalysts compared to SiO₂-based ones and IWI. Interestingly, Cu/SiO₂ catalyst prepared by CH was more selective to the main reaction product hexane-1,6-diol due to the presence of acid sites. In this paper, the catalyst hydrogenolysis activity was increased twice, compared to our previous experiments using Cu/ZnO prepared by deposition-precipitation

Catalysis Today published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, COA of Formula: C8H14O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Burgard, Niklas published the artcileThe Influence of Modified Experimental Dental Resin Composites on the Initial In Situ Biofilm-A Triple-Blinded, Randomized, Controlled Split-Mouth Trial, SDS of cas: 10287-53-3, the publication is Polymers (Basel, Switzerland) (2021), 13(16), 2814, database is CAplus and MEDLINE.

The purpose of the study was to investigate the bacterial viability of the initial biofilm on the surface of exptl. modified dental resin composites. Twenty-five healthy individuals with good oral hygiene were included in this study. In a split-mouth design, they received acrylic splints with five exptl. composite resin specimens. Four of them were modified with either a novel polymeric hollow-bead delivery system or methacrylated polymerizable Irgasan (Antibacterial B), while one specimen served as an unmodified control (ST). A delivery system based on Poly-Pore was loaded with one of the active agents: Tego Protect 5000 (Antiadhesive A), Dimethicone (Antiadhesive B), or Irgasan (Antibacterial A). All study subjects refrained from toothbrushing during the study period. Specimens were detached from the splints after 8 h and given a live/dead staining before fluorescence microscopy. A Friedman test and a post hoc Nemenyi test were applied with a significance level at p < 0.05. In summary, all materials but Antibacterial B showed a significant antibacterial effect compared to ST. The results suggested the role of the materials′ chem. in the dominance of cell adhesion. In conclusion, dental resin composites with Poly-Pore-loaded active agents showed antibacterial effectiveness in situ.

Polymers (Basel, Switzerland) published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, SDS of cas: 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Janchai, Khunanya published the artcileCrystallization behavior of isotactic polypropylene containing a fibrous nucleating agent in a flow field, Name: Tris(2,4-di-tert-butylphenyl) phosphite, the publication is Polymer Journal (Tokyo, Japan) (2022), 54(3), 367-375, database is CAplus.

The crystallization behavior of isotactic polypropylene containing a fibrous nucleating agent in a flow field was investigated using a polarized optical microscope equipped with a parallel-plate shear device. The addition of the fibrous nucleating agent greatly enhanced the crystallization rate, although isotactic polypropylene crystallization without the nucleating agent was enhanced after exposure to shear flow at a high shear rate. The sample with the nucleating agent demonstrated high mol. orientation to the flow direction after shear flow, even at a low shear rate. This was attributed to the formation of a pseudo shish-kebab structure, in which the fibrous nucleating agent acts as the shish. Moreover, the high level of mol. orientation without spherulitic morphol. was responsible for the reduced light scattering, which resulted in good transparency.

Polymer Journal (Tokyo, Japan) published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C42H63O3P, Name: Tris(2,4-di-tert-butylphenyl) phosphite.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Deb, Prashanta Kumar published the artcileVariation in chemical constituents, in-vitro bioactivity and toxicity profile among different parts of Clerodendrum glandulosum Lindl. (C. colebrookianum Walp.), Recommanded Product: Dimethyl adipate, the publication is South African Journal of Botany (2021), 50-61, database is CAplus.

In this study, chem., biol. and toxicity profile of hydromethanolic extracts of different parts (leaf, stem and root) of Clerodendrum glandulosum Lindl. were investigated simultaneously for the first time. Total phenolic and flavonoid contents were estimated spectrophotometrically. Untargeted metabolomics was performed using GC-MS and HPLC-PDA-MS to identify the individual secondary metabolites. Antioxidant potentials (DPPH, ABTS, FRAP, phosphomolybdenum, superoxide ion scavenging assay) were estimated and enzyme inhibition assays (α-glucosidase, α-amylase, pancreatic lipase, xanthine oxidase, angiotensin-converting enzyme) were performed. Cytotoxicity of the extracts in HepG2 and L6 cell lines along with acute oral toxicity was carried out. Leaf extract exhibited the highest phenolic (282.02 ± 5.87 mg GAE/g) and flavonoid (276.74 ± 5.08 mg QCE/g) content. Significantly (p<0.05) high antioxidant and enzyme inhibition potential was found in leaf extract as compared to stem and root. Leaf extract (IC50: 104.11 ± 0.36 μg/mL) exhibited comparatively better inhibition potential than standard inhibitor acarbose (IC50: 232.57 ± 3.28 μg/mL) against α-glucosidase enzyme. Chem. anal. confirmed the presence of verbascoside in all the three parts, whereas caffeic acid, other verbascoside derivatives, scutellarin, luteolin, and apigenin were identified in leaf. No cytotoxicity was demonstrated except by stem extract at higher concentration (1000 μg/mL). However, no in-vivo toxicity was demonstrated by extracts of any parts. These findings provides a brief overview on the chem. and biol. propensities of C. glandulosum Lindl. with possibility of its use in the management of various ailments.

South African Journal of Botany published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Recommanded Product: Dimethyl adipate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mohammadi Metkazini, S. Fatemeh published the artcileSustainable Visible Light-Driven Heck and Suzuki Reactions Using NiCu Nanoparticles Adorned on Carbon Nano-onions, Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(42), 14061-14069, database is CAplus.

NiCu nanoparticles supported on carbon nano-onion display astoundingly high photocatalytic activity for the Heck and Suzuki cross-coupling reactions. These reactions were performed under the irradiation of a mercury-vapor lamp (400 W) under mild and sustainable reaction conditions; visible light irradiation excites the electrons of metal nanoparticles, leading to the faster accomplishment of the reactions. This novel, easily accessible, and inexpensive noble-metal-free catalyst exhibited significant recyclability with no significant loss of catalytic activity after seven successive runs.

ACS Sustainable Chemistry & Engineering published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Prakash, Amruta published the artcileUltraviolet induced random mutagenesis in Bacillus amyloliquefaciens (MF 510169) for improving biodiesel production, Quality Control of 121-79-9, the publication is Fuel (2021), 121380, database is CAplus.

The present study aims to mutate Bacillus amyloliquefaciens (MF 510169) randomly for improving lipid accumulation towards green and efficient transformation of bacterial oil into biodiesel. The cellular lipid content of wild type Bacillus strain is improved by exposing the strain to UV light at 254 nm (UV-C) and 365 nm (UV-A) wavelengths for different time intervals from 20 to 380 s. A remarkable increase in lipid content is noted with increase in cell dry weight when exposed to UV-C with 320 s exposure time. The accumulated lipids are extracted and transesterified through acid catalyst (H₂SO₄, 1.52%) by various means for biodiesel production The chem. profiling of thus obtained biodiesel has been done by employing various spectroscopic techniques. The phys. and chem. properties of thus transesterified biodiesel are well-matching 86-90% with International ASTM standards The antioxidant stability of produced biodiesel tested with an addition of synthetic antioxidants remains stable for 25 d.

Fuel published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Quality Control of 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics