Month: December 2022

Abe, Ryota published the artcileLa(III)-Catalysed degradation of polyesters to monomers via transesterifications, Formula: C8H14O4, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(58), 8141-8144, database is CAplus and MEDLINE.

Tris(acetylacetonato)lanthanum(III) (1 mol%) catalyzes the degradation of poly(butylene succinate) (Mw = 90 700) by transesterification in MeOH at 90°C for 4 h, thus affording di-Me succinate (>99% yield) and 1,4-butanediol (98% yield). Moreover, the quant. degradations of poly(ethylene adipate), poly(ethylene terephthalate) and poly(butylene terephthalate) are also reported.

Chemical Communications (Cambridge, United Kingdom) published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Formula: C8H14O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Armanino, Nicolas published the artcileElectrophilic Trifluoromethylation of Primary Phosphines: Synthesis of a P-Bis(trifluoromethyl) Derivative of BINAP, Quality Control of 126613-06-7, the publication is Organometallics (2010), 29(7), 1771-1777, database is CAplus.

The new chiral diphosphine ligand (R)-(2′-(bis(trifluoromethyl)phosphino)-1,1′-binaphthyl-2-yl)diphenylphosphine (2, Ph₂PC₁₀H₆C₁₀H₆P(CF₃)₂), which contains a bis(trifluoromethyl)phosphine group, was prepared in five steps from (R)-BINOL (5). As a key transformation, the unprecedented electrophilic double trifluoromethylation of the primary phosphine H₂PC₁₀H₆C₁₀H₆OTf (8, OTf = triflate) was achieved using the hypervalent iodine trifluoromethylation reagent 1-trifluoromethyl-1,2-benziodoxol-3-(1H)-one (1), derived from o-iodobenzoic acid. The Pd dichloride complex of this ligand [PdCl₂(Ph₂PC₁₀H₆C₁₀H₆P(CF₃)₂)-κ²P,P] (10) shows the P(CF₃)₂ group with a high degree of pyramidalization at the P atom and a relatively short Pd-P bond (2.2230(4) Å), both features being indicative of the strong s-character of the P lone pair.

Organometallics published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Quality Control of 126613-06-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Alkattan, R. published the artcileBis[2-(Methacryloyloxy) Ethyl] Phosphate as a Primer for Enamel and Dentine, Recommanded Product: Ethyl 4-dimethylaminobenzoate, the publication is Journal of Dental Research (2021), 100(10), 1081-1089, database is CAplus and MEDLINE.

Dental resin composites are commonly used in the restorative management of teeth via adhesive bonding, which has evolved significantly over the past few decades. Although current self-etch bonding systems decrease the number of clin. steps, the acidic functional monomers employed exhibit a limited extent of demineralization of enamel in comparison to phosphoric acid etchants, and the resultant superficial ionic interactions are prone to hydrolysis. This study evaluates the etching of primers constituted with bis[2-(methacryloyloxy) ethyl] phosphate (BMEP) of dental hard tissue, interfacial characteristics, and inhibition of endogenous enzymes. We examine the incorporation of 2 concentrations of BMEP in the formulation of exptl. primers used with a hydrophobic adhesive to constitute a 2-step self-etching bonding system and compare to a com. 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP)-containing system. The interaction of the primer with enamel and dentin was characterized using scanning electron, confocal laser scanning, and Raman microscopy while the polymerization reaction between the BMEP primers and hydroxyapatite was evaluated by Fourier-transform IR spectroscopy. The inhibitory effect against matrix metalloproteinase (MMP) enzymes of these primers was studied and percentage of inhibition analyzed using 1-way anal. of variance and Tukey′s post hoc test (P < 0.05). Results of the SEM micrographs demonstrated potent etching of both enamel and dentin with the formation of longer resin tags with BMEP primers compared to the 10-MDP-based system. The BMEP polymerized on interaction with pure hydroxyapatite in the dark, while the 10-MDP primer exhibited the formation of salts. Furthermore, BMEP primers were able to inhibit MMP activity in a dose-dependent manner. BMEP could be used as a self-etching primer on enamel and dentin, and the high d.p. in the presence of hydroxyapatite can contribute to an increased quality of the resin polymer network, prompting resistance to gelatinolytic and collagenolytic degradation

Journal of Dental Research published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Recommanded Product: Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Heimburg, Tino published the artcileStructure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity, COA of Formula: C9H8O4, the publication is Journal of Medicinal Chemistry (2017), 60(24), 10188-10204, database is CAplus and MEDLINE.

Histone deacetylases (HDACs) are important modulators of epigenetic gene regulation and addnl. control the activity of non-histone protein substrates. While for HDACs 1-3 and 6 many potent selective inhibitors have been obtained, for other subtypes much less is known on selective inhibitors and the consequences of their inhibition. The present report describes the development of substituted benzhydroxamic acids as potent and selective HDAC8 inhibitors. Docking studies using available crystal structures have been used for structure-based optimization of this series of compounds Within this study, the authors have investigated the role of HDAC8 in the proliferation of cancer cells and optimized hits for potency and selectivity, both in vitro and in cell culture. The combination of structure-based design, synthesis, and in vitro screening to cellular testing resulted in potent and selective HDAC8 inhibitors that showed anti-neuroblastoma activity in cellular testing.

Journal of Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, COA of Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pritykin, L. M. published the artcileTo evaluation of the steric effect in organic compounds, Synthetic Route of 5340-78-3, the publication is Journal of Structural Chemistry (Translation of Zhurnal Strukturnoi Khimii) (2001), 41(5), 901-904, database is CAplus.

A new approach was developed to calculation of solid angles, which are a measure of steric effect in organic mols.; the approach is based on the geometrical model. The solution is implemented as a computer program.

Journal of Structural Chemistry (Translation of Zhurnal Strukturnoi Khimii) published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Synthetic Route of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mateliene, Lauryna published the artcileBenign Arylations of Dimethyl Itaconate via Heck-Matsuda Reaction Utilizing in-Situ Generated Palladium on Aluminum Oxide, Recommanded Product: Dimethyl itaconate, the publication is European Journal of Organic Chemistry (2020), 2020(1), 127-135, database is CAplus.

In situ generated palladium on aluminum oxide provides an active and efficient catalytic system for the preparation of arylmethylidene succinates using the Heck-Matsuda reaction. Beside the monoarylation the first examples of the biarylation of these monomers will be described.

European Journal of Organic Chemistry published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Recommanded Product: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lund, Birgitte W. published the artcileDesign, Synthesis, and Structure-Activity Analysis of Isoform-Selective Retinoic Acid Receptor β Ligands, Category: esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (2009), 52(6), 1540-1545, database is CAplus and MEDLINE.

We recently discovered the isoform selective RARβ2 ligand 4′-octyl-4-biphenylcarboxylic acid (3, AC-55649)(I). Although 3 is highly potent at RARβ2 and displays excellent selectivity, solubility issues make it unsuitable for drug development. Herein we describe the exploration of the SAR in a biphenyl and a phenylthiazole series of analogs of 3. This ultimately led to the design of 28 (II), a novel, orally available ligand with excellent isoform selectivity for the RARβ2.

Journal of Medicinal Chemistry published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Papadopoulos, Lazaros published the artcileStraightforward synthetic protocol to bio-based unsaturated poly(ester amide)s from itaconic acid with thixotropic behavior, Application In Synthesis of 617-52-7, the publication is Polymers (Basel, Switzerland) (2020), 12(4), 980, database is CAplus and MEDLINE.

In the field of polymer chem., tremendous efforts have been made over the last decade to replace petrochem. monomers with building blocks from renewable resources. In this respect, itaconic acid has been used as an alternative to acrylic acid or maleic acid in unsaturated polyesters for thermal or UV-curing applications. However, examples of poly(ester amide)s from itaconic acid are scarce. Under standard polycondensation reactions, the presence of free amines leads to aza-Michael addition reactions at the α,β-unsaturated double bond of the itaconic acid and isomerization reactions to mesaconic acid. Both reactions make the resulting materials useless as UV-curing polymer resins. To avoid these undesired side reactions, we herein report the use of preformed, well-defined diols containing internal amide bonds. The resulting unsaturated poly(ester amide) resins were analyzed before and after UV-induced crosslinking. Viscosity measurements revealed a strong thixotropic behavior induced by the amide groups, which is usually not detected in structurally similar polyester resins.

Polymers (Basel, Switzerland) published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Application In Synthesis of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Meng, Qi published the artcileContribution of 2-methyl-3-furanthiol to the cooked meat-like aroma of fermented soy sauce, Safety of Ethyl 2-mercaptopropanoate, the publication is Bioscience, Biotechnology, and Biochemistry (2017), 81(1), 168-172, database is CAplus and MEDLINE.

The cooked meat-like aroma compound, 2-methyl-3-furanthiol (2M3F), was detected in fermented soy sauce (FSS) by GC-olfactometry and GC-MS. 2M3F was present in FSS at a concentration considerably greater than the perception threshold, and the 2M3F concentration increased with heating temperature Sensory anal. indicated that with the addition of only 0.2 μg/L of 2M3F to the soy sauce sample, the cooked meat-like aroma is significantly stronger than that of sample without the addition of 2M3F. Hence, 2M3F contributes to the cooked meat-like aroma of FSS, which constitutes the key aroma component of FSS. In addition, 2M3F was generated from the addition of ribose and cysteine in FSS by heating at 120 °C, but it was not detected in a phosphate buffer under the same condition. Furthermore, 2M3F was not detected in acid-hydrolyzed vegetable-protein-mixed soy sauce (ASS) and heated ASS. These results indicated that fermentation by micro-organisms facilitates the generation of 2M3F in FSS.

Bioscience, Biotechnology, and Biochemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Safety of Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nishimoto, Yoshihiro published the artcileCoupling reaction of enol derivatives with silyl ketene acetals catalyzed by gallium trihalides, Recommanded Product: Ethyltert-butylacetate, the publication is Chemistry – A European Journal (2016), 22(33), 11837-11845, database is CAplus and MEDLINE.

A cross-coupling reaction between enol derivatives and silyl ketene acetals catalyzed by GaBr₃ took place to give the corresponding α-alkenyl esters. GaBr₃ showed the most effective catalytic ability, whereas other metal salts such as BF₃·OEt₂, AlCl₃, PdCl₂, and lanthanide triflates were not effective. Various types of enol ethers and vinyl carboxylates as enol derivatives are amenable to this coupling. The scope of the reaction with silyl ketene acetals was also broad. We successfully observed an alkylgallium intermediate by using NMR spectroscopy, suggesting a mechanism involving anti-carbogallation among GaBr₃, an enol derivative, and a silyl ketene acetal, followed by syn-β-alkoxy elimination from the alkylgallium. Based on kinetic studies, the turnover-limiting step of the reaction using a vinyl ether and a vinyl carboxylate involved syn-β-alkoxy elimination and anti-carbogallation, resp. Therefore, the leaving group had a significant effect on the progress of the reaction. Theor. calculations anal. suggest that the moderate Lewis acidity of gallium would contribute to a flexible conformational change of the alkylgallium intermediate and to the cleavage of the carbon-oxygen bond in the β-alkoxy elimination process, which is the turnover-limiting step in the reaction between a vinyl ether and a silyl ketene acetal.

Chemistry – A European Journal published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Recommanded Product: Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics