Month: December 2022

Gautam, Anurag Kumar published the artcilePreclinical evaluation of dimethyl itaconate against hepatocellular carcinoma via activation of the e/iNOS-mediated NF-κB-dependent apoptotic pathway, COA of Formula: C7H10O4, the publication is Frontiers in Pharmacology (2021), 823285, database is CAplus and MEDLINE.

Hepatocellular carcinoma (HCC) is one of the most common tumors affecting a large population worldwide, with the fifth and seventh greatest mortality rates among men and women, resp., and the third prime cause of mortality among cancer victims. Di-Me itaconate (DI) has been reported to be efficacious in colorectal cancer by decreasing IL-1β release from intestinal epithelial cells. In this study, diethylnitrosamine (DEN)-induced HCC in male albino Wistar rats was treated with DI as an anticancer drug. The function and mol. mechanism of DI against HCC in vivo were assessed using histopathol., ELISA (ELISA), and Western blot studies. Metabolomics using 1H-NMR was used to investigate metabolic profiles. As per mol. insights, DI has the ability to trigger mitochondrial apoptosis through iNOS- and eNOS-induced activation of the NF-κB/Bcl-2 family of proteins, CytC, caspase-3, and caspase-9 signaling cascade. Serum metabolomics investigations using 1H-NMR revealed that aberrant metabolites in DEN-induced HCC rats were restored to normal following DI therapy. Furthermore, our data revealed that the DI worked as an anti-HCC agent. The anticancer activity of DI was shown to be equivalent to that of the com. chemotherapeutic drug 5-fluorouracil.

Frontiers in Pharmacology published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, COA of Formula: C7H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Prasad, Bhim Bali published the artcileSol-gel derived multiwalled carbon nanotubes ceramic electrode modified with molecularly imprinted polymer for ultra trace sensing of dopamine in real samples, HPLC of Formula: 3052-61-7, the publication is Electrochimica Acta (2011), 56(20), 7202-7211, database is CAplus.

A new class of composite electrodes made of sol-gel derived ceramic-multiwalled C nanotubes was used for the growth of a nanometer thin film adopting surface grafting-from approach. For this the multiwalled C nanotubes-ceramic electrode surface is 1st modified with an iniferter (benzyl N,N-diethyldithiocarbamate) and then dopamine imprinted polymer, under UV irradiation, for differential pulse anodic stripping voltammetric sensing of dopamine in aqueous, blood serum, cerebrospinal fluid, and pharmaceutical samples (detection limit 0.143-0.154 ng mL^-1, 3σ), without any cross reactivity, interferences and false-pos. contributions. Such composite electrodes offer higher stability, electron kinetics, and renewable porous surface of larger electroactive area (with insignificant capacitance) than C ceramic electrodes. Addnl. cyclic voltammetry (stripping mode) and chronocoulometry experiments were performed to explore electrodics and kinetics of electrooxidation of dopamine.

Electrochimica Acta published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, HPLC of Formula: 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pathak, Purnendu Kumar published the artcileA novel electrocatalytic nanocomposite of reduced graphene oxide/silver nanocube hybrid decorated imprinted polymer for ultra-trace sensing of temozolomide, Safety of Benzyl diethylcarbamodithioate, the publication is New Journal of Chemistry (2018), 42(16), 13486-13496, database is CAplus.

A new nanocomposite of reduced graphene oxide/silver nanocube hybrid decorated molecularly imprinted polymer at the surface of a screen-printed carbon electrode was developed for the electroanal. of an anticancerous drug, temozolomide, at the ultra-trace level. For this, a hybrid of reduced graphene oxide/silver nanocubes was successfully obtained through the simultaneous reduction of Ag⁺ and graphene oxide via simple one-pot green synthesis. Among the various shapes of nanomaterials used in imprinted polymer synthesis, silver nanocubes, as evident from SEM, TEM and, X-ray diffraction methods, have been found to render high surface to volume ratios and a higher electrocatalytic activity. Herein, the synergistic electrocatalytic effect of reduced graphene oxide and silver nanocubes was utilized for decreasing the analyte oxidation overpotential, without any interfacial barrier in between the imprinted film and the electrode surface, owing to the porous texture of the coating. Consequently, approx. 3-fold differential pulse anodic stripping current and ∼5-fold electron transfer rate kinetics were obtained on the reduced graphene oxide/silver nanocube hybrid compared with the simple graphene oxide decorated sensor. The covalent Ag-S links, in between the imprinted film and the silver nanocube decorated screen-printed carbon electrode, were crucial for imparting higher stability to the coating of the film. A perfect linearity in the current-concentration profile was observed, in the range 1.09-144.21 ng mL^-1, with the detection limits of 0.16 (aqueous), 0.24 (blood plasma), 0.31 (pharmaceutics), and 0.42 (urine) ng mL^-1 (S/N = 3). The proposed sensor was found to be useful in aqueous and real samples (human blood plasma, human urine, and pharmaceutics), without any matrix effect, cross-reactivity, or false-positives.

New Journal of Chemistry published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Safety of Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Guozhong published the artcileEffect of steam explosion on physicochemical properties and fermentation characteristics of sorghum (Sorghum bicolor (L.) Moench), Product Details of C20H40O2, the publication is LWT–Food Science and Technology (2020), 109579, database is CAplus.

Steam explosion (SE) was applied to modify the physicochem. properties and fermentation characteristics of sorghum (Sorghum bicolor (L.) Moench). SEM (SEM) showed that the dense structures of sorghum especially the starch granules were destroyed, and much more folds, crimps and holes appeared in sorghum starch. Cellulose, hemicellulose and proteins in sorghum tended to decrease when the SE pressure increased which were investigated by fourier transformed IR (FTIR) spectroscopy and SDS-PAGE. SE pretreatment increased the content of reducing sugar in sorghum, and the content of reducing sugar in sorghum pretreated by SE of 2.0 MPa increased over 19 times than the control. Moreover, fermentation results indicated that the ethanol yield was over 2 times higher than the control under the pressure of 1.5 MPa. The fermentation broth increased and the fermentation residue decreased obviously by SE pretreatment than the control. The kinds and the relative contents of esters increased, especially the Et acetate. This study suggested that SE pretreatment could reduce the waste content and promote the ethanol production in the liquor industry.

LWT–Food Science and Technology published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C8H17Br, Product Details of C20H40O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Thesen, Manuel W. published the artcileInvestigation of spacer influences in phosphorescent-emitting nonconjugated PLED systems, Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2010), 48(2), 389-402, database is CAplus.

An assay was introduced to clarify influences on electroluminescent behavior for RGB-colored phosphorescent terpolymers with N,N-Di-p-tolyl-aniline as hole-transporting unit, 2-(4-biphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (tert-BuPBD) as electron-transporting unit, and different iridium complexes in RGB-colors as triplet emitting materials. All monomers were attached with spacer moieties to the “para” position of a polystyrene. Polymer light emitting diodes (PLEDs) were built to study the electro-optical behavior of these materials. The gist was a remarkable influence of hexyl-spacer units to the PLED performance. For all three colors only very restricted PLED performances were found. In comparison RGB-terpolymers were synthesized with directly attached charge transport materials to the polymer backbone. For this directly linked systems efficiencies were 28 cd A^-1 @ 6 V (green), 4.9 cd A^-1 @ 5 V (red) and 4.3 cd A^-1 @ 6 V (bluish). In summary we assume that an improved charge percolation pathways regarding to the higher content of semiconducting mols. and an improved charge transfer to the phosphorescent dopant in the case of the copolymers without spacers are responsible for the better device performance comparing the copolymers with hexyl spacers. The approach of the directly connected charge transport materials at the nonconjugated styrene polymer backbone should be favored for further investigations, therefore. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 389-402, 2010.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C9H9NO6S, Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tomal, Wiktoria published the artcileBeneficial stilbene-based derivatives: From the synthesis of new catalytic photosensitizer to 3D printouts and fiber-reinforced composites, Synthetic Route of 10287-53-3, the publication is European Polymer Journal (2021), 110603, database is CAplus.

New meta- and para-cyanoderivatives of 1,4-di(styryl)benzene and 1,3-di(styryl)benzene were synthesized and investigated for their use as photosensitizers of iodonium salt for various photopolymerization processes. Detail spectroscopic characteristic of this compound were performed, and the mechanism of initiation in binary photoinitiating system together with iodine salt was discussed and confirmed by experiments Using real-time FTIR, the usefulness of the proposed meta- and para-cyanoderivatives of 1,4-di(styryl)benzene and 1,3-di(styryl)benzene as highly efficient photosensitizers for various photopolymerization processes was tested, including: free-radical photopolymerization of acrylate monomer or cationic photopolymerization of epoxy and glycidyl monomers. In addition, the formation of interpenetrating polymer networks with the use of proposed two-component initiating systems was performed. Encouraged by excellent polymerization results with the use of the developed initiating systems, addnl. application tests were carried out, including: 3D printing using vat polymerization, visible based direct ink writing, preparation of various fiber-reinforced composite or formation of multiwalled carbon nanotubes composites (MWCNTs nanocomposites), for which the manufacturing process has been analyzed in detail using real-time FTIR method.

European Polymer Journal published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C10H10CoF6P, Synthetic Route of 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Thiyagarajan, Subramanian published the artcileKOtBu-Catalyzed Michael Addition Reactions Under Mild and Solvent-Free Conditions, HPLC of Formula: 517-23-7, the publication is Chemistry – An Asian Journal (2020), 15(4), 518-523, database is CAplus and MEDLINE.

Herein, a mild and environmentally friendly strategy of readily available KOtBu-catalyzed Michael addition reactions was demonstrated. This simple inorganic base efficiently catalyzed the Michael addition of underexplored acrylonitriles, esters and amides with oxa-, aza-, and thia-heteroatom nucleophiles to afford Michael addition products. This catalytic process proceeded under solvent-free conditions and at room temperature Notably, this protocol offered an easy operational procedure, broad substrate scope with excellent selectivity, reaction scalability and excellent TON (>9900). Preliminary mechanistic studies revealed that the reaction followed an ionic mechanism. Formal synthesis of promazine was demonstrated using this catalytic protocol.

Chemistry – An Asian Journal published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C5H12O2, HPLC of Formula: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Brewer, J. Wayne published the artcileForest Lepidoptera attracted to six synthetic pheromones in Czechoslovakia, Quality Control of 16974-11-1, the publication is Zeitschrift fuer Angewandte Entomologie (1985), 100(4), 372-81, database is CAplus.

The attractiveness of 6 synthetic pheromones to forest Lepidoptera was studied at 2 locations in Czechoslovakia during 1983. The synthetic attractants tested included pheromones for Choristoneura fumiferana (Tortricidae), Eucosma sonomana (Olethreutidae), Lymantria dispar (Lymantriidae), Orgyia pseudotsugata, Rhyacionia frustrana, and R. buoliana. The attractant for R. buoliana, (E)-9-dodecenyl acetate, was prepared in Czechoslovakia for use with European species but the other 5 materials are of North American origin and intended for use with species there. Sticky traps baited with these pheromones captured some 32 species in 26 genera with significant numbers of species as follows: Traps with the C. fumiferana attractant contained Acleris sparsana and Cnephasia stephensiana. Those with the E. sonomana attractant contained Enarmonia formosana and Caradrina morpheus. The L. dispar pheromone attracted 354 L. monacha and merely 14 L. dispar. The traps for O. pseudotsugata contained O. antiqua and those baitedwith the R. frustrana pheromone contained Cnephasia interjectana and Dichrorampha simpliciana. Traps with the R. buoliana attractant contained Gypsonoma oppressana. Thus, substantial species, genus and family cross attraction occurs with some of the synthetic sex attractants tested.

Zeitschrift fuer Angewandte Entomologie published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Quality Control of 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Demkowicz, Sebastian published the artcilePhosphate and Thiophosphate Biphenyl Analogs as Steroid Sulfatase Inhibitors, Category: esters-buliding-blocks, the publication is Drug Development Research (2015), 76(2), 94-104, database is CAplus and MEDLINE.

Preclin. Research In the present work, we report convenient methods for the synthesis and biol. evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity. The described synthesis is based on straightforward preparation of biphenyl-4-ol and 4′-hydroxy-biphenyl-4-carboxylic acid Et ester modified with various phosphate or thiophosphate moieties. The inhibitory effects of these compounds were tested on STS isolated from human placenta and led to two compounds of interest, 5a and 5d with IC₅₀ values of 28.0 and 22.1 μM, resp. and that had interesting new binding modes in the STS active site. Drug Dev Res, 2015. © 2015 Wiley Periodicals, Inc.

Drug Development Research published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nouri Parouch, Ahmad published the artcilePalladium and silk fibroin-containing magnetic nano-biocomposite: a highly efficient heterogeneous nanocatalyst in Heck coupling reactions, Category: esters-buliding-blocks, the publication is Research on Chemical Intermediates (2021), 47(8), 3165-3177, database is CAplus.

Supported metal catalysts, for instance, palladium, are one of the foundations of chem. reactions, especially in C-C bond formation. The present study reports preparation of a magnetically separable palladium-supported nano-biocomposite with a low cost and easy immobilization technique. Fibroin, a natural biodegradable polymer, was used through an in situ method to cover the Fe₃O₄ nanoparticles to make a nano-biocomposite followed by anchoring palladium on the fibroin surface. The morphol. and the structure of palladium-supported nano-biocomposite Fe₃O₄@fibroin-Pd were characterized by FT-IR, XRD, TGA, SEM, EDX, and TEM techniques. Consequently, the nanocatalyst activity was evaluated in the Heck coupling reactions. Only a very small amount of the nanocatalyst was employed in the reaction, and it showed excellent catalytic activity; in most cases more than 90% efficiency. The significant advantages of employing this nanocatalyst include high catalytic activity, short reaction times, easy separation of the nanocatalyst with an external magnet and great reusability. The results demonstrated that the used nanocatalysts were very active for four consecutive reaction rounds.

Research on Chemical Intermediates published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics