Month: December 2022

Renou, Michel published the artcileMultivariate analysis of the correlation between noctuidae subfamilies and the chemical structure of their sex pheromones or male attractants, HPLC of Formula: 16974-11-1, the publication is Journal of Chemical Ecology (1988), 14(4), 1187-1215, database is CAplus and MEDLINE.

Female-emitted pheromones and sex attractants of Noctuidae were investigated by using a specific computer procedure to analyze data collected from the literature. Correspondence anal. was used to survey the structure-activity relationships of sex pheromones in 7 subfamilies. Structural, stereochem., and functional features of active mols. were related to taxonomy. This multidimensional anal. revealed that the prevalent chem. frame of noctuid moth pheromones was a monosatd. acetate with Z stereochem. and a double bond on the 5th carbon closest to the nonfunctional branch of the mol. Possible phylogenetic relationships within Noctuidae and between Noctuidae and other families are discussed in light of the sex pheromone biochem. Female sex pheromones appeared to be an addnl. character to be considered in the classification of noctuid moths.

Journal of Chemical Ecology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, HPLC of Formula: 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Renou, M. published the artcileSexual pheromones of Noctuidae from the Antilles. Electrophysiological studies, Computed Properties of 16974-11-1, the publication is Colloques – Institut National de la Recherche Agronomique (1988), 46(Mediateurs Chim.: Comportement Syst. Lepidopteres), 21-33, database is CAplus.

Light trapping of native males and electroantennog. measurements were used to study the antennal sensitivity of 80 species of Noctuidae from Guadeloupe. For the electroantennog. tests, 160 synthetic pheromonal compounds were used. From key-compound determination and response profile anal., the chem. structure of female-emitted pheromones was inferred. Differences in olfactory sensitivity between Noctuidae subfamilies were discussed with respect to the biosystematic relations.

Colloques – Institut National de la Recherche Agronomique published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Computed Properties of 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Des Azevedo, Sonia published the artcileMolecularly Imprinted Polymer-Hybrid Electrochemical Sensor for the Detection of β-Estradiol, Category: esters-buliding-blocks, the publication is Industrial & Engineering Chemistry Research (2013), 52(39), 13917-13923, database is CAplus.

This paper discusses the construction of a novel electrochem. sensor for 17β-estradiol (E2) based on a molecularly imprinted polymer (MIP)-conducting polymer modified hybrid electrode. A bifunctional monomer, N-phenylethylene diamine methacrylamide (NPEDMA), was used for the construction of the electrochem. sensor. Conducting films were prepared on the surface of a gold electrode by electropolymerization of the aniline moiety of NPEDMA. A layer of MIP was photochem. grafted over the polyaniline, via N,N-diethyldithiocarbamic acid benzyl ester (iniferter) activation of the methacrylamide groups. Computational modeling was used to select the most suitable monomer for preparation of MIPs for E2. Exptl. parameters such as deposition time, cyclic voltammetric (CV) scan cycles, and conditions for polymer accumulation were optimized. The detection limit of the resulting sensor, determined by CV, was 6.86 × 10^-7 M. Furthermore, the hybrid electrode was successfully used to analyze E2 in water without complex sample pretreatment. These results reveal that the MIP hybrid sensor has potential to be an effective technique for the electrochem. determination of E2 in real-time in complicated matrixes.

Industrial & Engineering Chemistry Research published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wu, Zhiyong published the artcileAn Efficient Synthesis of Benzyl Dithiocarbamates by Base-Promoted Cross-Coupling Reactions of Benzyl Chlorides with Tetraalkylthiuram Disulfides at Room Temperature, Recommanded Product: Benzyl diethylcarbamodithioate, the publication is European Journal of Organic Chemistry (2018), 2018(48), 7033-7036, database is CAplus.

A straightforward, mild and efficient protocol for the synthesis of benzyl dithiocarbamates from benzyl chlorides and tetraalkylthiuram disulfides is presented. This protocol is compatible with a wide variety of electron-donating and -withdrawing substituents and enables construction of various dithiocarbamate derivatives from readily available starting materials.

European Journal of Organic Chemistry published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C38H24F4O4P2, Recommanded Product: Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ferreira da Silveira, Tayse Ferreira published the artcileImpact of surfactant concentration and antioxidant mode of incorporation on the oxidative stability of oil-in-water nanoemulsions, SDS of cas: 121-79-9, the publication is LWT–Food Science and Technology (2021), 110892, database is CAplus.

The effect of the presence of surfactant micelles and of the mode of incorporation (pre-homogenization or post-homogenization) on the antioxidant efficiency of a homologous series of n-alkyl gallates phenolipids (G0, G3, G8, G12 or G16) was investigated in oil-in-water nanoemulsions. In both absence and presence of surfactant micelles, G12 and G16 were the best antioxidants. The effect of the mode of incorporation was modulated by the presence of surfactant micelles. In absence of surfactant micelles, G8 and G16 had higher efficiency when incorporated pre-homogenization, suggesting that the mode of incorporation promoted a distinct initial distribution of these compounds In contrast, in presence of surfactant micelles, the antioxidants could be incorporated in any phases without efficiency loss. These results demonstrate the important role of surfactant micelles in modulating the antioxidant efficiency and could be used by the food industry to optimize emulsion formulations.

LWT–Food Science and Technology published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, SDS of cas: 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Marquis, Robert W. published the artcileAntagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues, Computed Properties of 115314-17-5, the publication is Journal of Medicinal Chemistry (2009), 52(13), 3982-3993, database is CAplus and MEDLINE.

Functional screening of the former SmithKline Beecham compound collection against the human calcium receptor (CaR) resulted in the identification of the amino alc.-based hit 2 (IC₅₀ = 11 μM). Structure-activity studies of 2 focused on the optimization of the right- and left-hand side aromatic moieties as well as the amino alc. linker region. Critical to the optimization of this antagonist template was the discovery that the chirality of the C-2 secondary alc. played a key role in enhancing both CaR potency as well as selectivity over the β-adrenergic receptor subtypes. These SAR studies ultimately led to the identification of 38 (NPS 2143; SB-262470A), a potent and orally active CaR antagonist. Pharmacokinetic characterization of 38 in the rat revealed that this mol. had a large volume of distribution (11 L/kg), which resulted in a prolonged systemic exposure, protracted increases in the plasma levels of PTH, and an overall lack of net bone formation effect in a rodent model of osteoporosis.

Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Computed Properties of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ding, Bao-Jian published the artcileThe Yeast ATF1 Acetyltransferase Efficiently Acetylates Insect Pheromone Alcohols: Implications for the Biological Production of Moth Pheromones, Quality Control of 16974-11-1, the publication is Lipids (2016), 51(4), 469-475, database is CAplus and MEDLINE.

Many moth pheromones are composed of mixtures of acetates of long-chain (≥10 carbon) fatty alcs. Moth pheromone precursors such as fatty acids and fatty alcs. can be produced in yeast by the heterologous expression of genes involved in insect pheromone production Acetyltransferases that subsequently catalyze the formation of acetates by transfer of the acetate unit from acetyl-CoA to a fatty alc. have been postulated in pheromone biosynthesis. However, so far no fatty alc. acetyltransferases responsible for the production of straight chain alkyl acetate pheromone components in insects have been identified. In search for a non-insect acetyltransferase alternative, we expressed a plant-derived diacylglycerol acetyltransferase (EaDAcT) (EC 2.3.1.20) cloned from the seed of the burning bush (Euonymus alatus) in a yeast system. EaDAcT transformed various fatty alc. insect pheromone precursors into acetates but we also found high background acetylation activities. Only one enzyme in yeast was shown to be responsible for the majority of that background activity, the acetyltransferase ATF1 (EC 2.3.1.84). We further investigated the usefulness of ATF1 for the conversion of moth pheromone alcs. into acetates in comparison with EaDAcT. Overexpression of ATF1 revealed that it was capable of acetylating these fatty alcs. with chain lengths from 10 to 18 carbons with up to 27- and 10-fold higher in vivo and in vitro efficiency, resp., compared to EaDAcT. The ATF1 enzyme thus has the potential to serve as the missing enzyme in the reconstruction of the biosynthetic pathway of insect acetate pheromones from precursor fatty acids in yeast.

Lipids published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Quality Control of 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Severac, Romain published the artcileReversible addition-fragmentation chain-transfer (RAFT) copolymerization of vinylidene chloride and methyl acrylate, Product Details of C5H10O2S, the publication is Polymer International (2002), 51(10), 1117-1122, database is CAplus.

The reversible addition-fragmentation chain-transfer (RAFT) copolymerization of vinylidene chloride with Me acrylate was investigated at 70°C in benzene. Three benzodithioate chain-transfer agents were synthesized in high yield by a simple and straightforward transesterification method. These dithioesters were successfully used as reversible chain-transfer agents, as demonstrated by the increase of mol. weight with conversion, a relatively low polydispersity index (I_p = 1.5) in comparison with a blank experiment (I_p = 1.9), first-order polymerization kinetics, and efficient chain extension. Nevertheless, a transfer reaction to vinylidene chloride monomer was considered to address the limitations of the RAFT process for this system. Moreover, a retardation effect was noticeable on the kinetics, depending on the structure and concentration of the transfer agent, leading to lower rate of polymerization for lower targeted mol. weights

Polymer International published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C18H34N4O5S, Product Details of C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hansen, Hanne D. published the artcileSynthesis, radiolabeling and in vivo evaluation of [¹¹C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT₇ receptor, Recommanded Product: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, the publication is European Journal of Medicinal Chemistry (2014), 152-163, database is CAplus and MEDLINE.

In the search for a novel serotonin 7 (5-HT₇) receptor PET radioligand we synthesized and evaluated a new series of biphenylpiperazine derivatives in vitro. Among the studied compounds, (R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, showed the best combination of affinity, selectivity, and lipophilicity, and was thus chosen for carbon-11 labeling and evaluation in pigs. After i.v. injection, compound I entered the pig brain and displayed reversible tracer kinetics. Pretreatment with the 5-HT₇ receptor selective antagonist SB-269970 resulted in limited decrease in the binding of I, suggesting that this radioligand is not optimal for imaging the brain 5-HT₇ receptor in vivo but it may serve as a lead compound for the design of novel 5-HT₇ receptor PET radioligands.

European Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Recommanded Product: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Levoin, Nicolas published the artcileNovel and highly potent histamine H3 receptor ligands. Part 1: withdrawing of hERG activity, Quality Control of 50670-76-3, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(18), 5378-5383, database is CAplus and MEDLINE.

Pre-clin. investigation of some aryl-piperidinyl ether histamine H3 receptor antagonists revealed a strong hERG binding. To overcome this issue, we have developed a QSAR model specially dedicated to H3 receptor ligands. This model was designed to be directly applicable in medicinal chem. with no need of mol. modeling. The resulting recursive partitioning trees are robust (80-85% accuracy), but also simple and comprehensible. A novel promising lead I emerged from our work and the structure-activity relationships are presented.

Bioorganic & Medicinal Chemistry Letters published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Quality Control of 50670-76-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics