Month: December 2022

Kim, Dae Seok published the artcileSelf-Regulated Smectic Emulsion with Switchable Lasing Application, Category: esters-buliding-blocks, the publication is Small (2019), 15(49), 1903818, database is CAplus and MEDLINE.

A structurally reversible smectic liquid crystal (LC) emulsion made of semifluorinated rod-type mols. in silicone oil, which is controlled by simple heating and cooling, is presented. Without adding any kind of additives, such as surfactants, polymers or emulsifiers, and without using any special tools, such as microfluidics or gas bubbling, the LC mols. spontaneously form monodisperse spherical and myelin-like structures upon cooling from the isotropic temperature The LC emulsion can easily trap guest materials, providing a platform for repeatable and reliable switchable emulsification. For example, this interesting system enables the realization of an on-off lasing system by confining fluorescent dyes in the LC droplets.

Small published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kim, Jae-Hoon published the artcileα,ω-Bis[4-(4′-(S)-(+)-2-methylbutylbiphenyl-4-carboxy)phenoxy]alkanes – synthesis and liquid crystalline properties of new dimesogenic compounds, SDS of cas: 50670-76-3, the publication is Journal of the Korean Chemical Society (1998), 42(6), 679-695, database is CAplus.

α,ω-Bis[4-(4′-(S)-(+)-2-methylbutoxybiphenyl-4-carboxy)phenoxy]alkanes were synthesized, and their thermal and liquid crystalline properties were studied. The chains length of the central polymethylene spacers, x, of the chiral twin compounds was varied from 3 to 12. These compounds were characterized by elemental analyses, IR and NMR spectroscopy, DTA (DSC), and cross-polarized microscopy. All compounds are enantiotropic liquid crystalline, and the values of melting (Tm) and isotropization temperature (T_i) as well as ΔH₄ and ΔS_i decreased in a zigzag fashion, revealing the so-called odd-even effect as x increased. Their mesomorphic properties fell into four categories depending on x. Compounds with x = 3, 4 and 5 formed only a cholesteric phase on heating, while on cooling they went through two transitions of isotropic (I)-to-cholesteric (Ch) and Ch-to-smectic A (S_A) phases before crystallization Compounds with x = 6, 8 and 10 exhibited only a cholesteric phase both on heating and on cooling. Compounds with x = 7 and 9 went through three transitions of crystal (C)-to-S_A, S_A-to-Ch, and Ch-to-I phases on heating while on cooling they went through four transitions of I-to-Ch, Ch-to-S_A, S_A-to-Smectic C (S_C), and S_C-to-C phases in that order. Compounds with x = 11 and 12 went reversibly through four transitions of C-to-S_C, S_C-to-S_A, S_A-to-Ch, and Ch-to-I phases.

Journal of the Korean Chemical Society published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, SDS of cas: 50670-76-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Patel, Meera published the artcileDescriptive aroma profiles of fresh sweet basil cultivars (Ocimum spp.): Relationship to volatile chemical composition, Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is Journal of Food Science (2021), 86(7), 3228-3239, database is CAplus and MEDLINE.

Few studies have linked sensory descriptions of the aroma profiles of fresh, sweet basil varieties with their volatile chem. Using a recently developed lexicon for fresh basil, a descriptive panel characterized the aroma profiles of seven basil varieties. Chem. anal. of fresh basil leaves was performed using GC-MS headspace anal. Anal. of variance probed for differences in the sensory attributes among varieties and principal component anal. (PCA) related the sensory profiles to volatile chem. composition Three com. specialty basils, “Queenette Thai” (QT), “Sweet-Dani” (SD) lemon basil, and MC-9 (cinnamon basil) had strong anise, lemon, and cinnamon-like aromas, resp. These basils were distinguished from breeding lines of traditional Italian sweet basils where SB-22, CB-1, and CB-39 exhibited strong anise-like aroma and SB-17 had strong “general spice” aromas, characteristic of a warm spice blend. The PCA accounted for 58.7% of the variation in the data and characterized the samples in two dimensions: general spice-citrus and cinnamon-like-anise. There was a strong correspondence between the sensory attributes and volatile chem. composition SD associated with lemon aroma and citral content; QT, CB-1, and CB-39 associated with anise aroma and Me chavicol; and MC-9 associated with the cinnamon-like aroma, Me cinnamate. SB-17 and SB-22 associated with general spice aroma and were in close proximity to the spice-like volatiles, 1,8 cineole, and eugenol, associated with clove aroma. We constructed precise sensory/chem. profiles for fresh basil aroma that can be used to guide breeding programs for variety improvement to meet consumer expectations or market demand.

Journal of Food Science published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Feng, Pengju published the artcileAccess to a new class of synthetic building blocks via trifluoromethoxylation of pyridines and pyrimidines, SDS of cas: 1448637-05-5, the publication is Chemical Science (2016), 7(1), 424-429, database is CAplus and MEDLINE.

A scalable and operationally simple protocol for regioselective trifluoromethoxylation of a wide range of functionalized pyridines I [R = 5-Br-6-OMe, 6-(1H-Benzo[d]imidazol-1-yl), 6-(1H-pyrazol-1-yl), etc.; R¹ = OMe, Me; X = OH; Y = H] and pyrimidines II [R² = (2-(Thiazol-4-yl)-1H-benzo[d]imidazol-1-yl), 2-OMe, 4-Cl-3,5-(Me)₂-OC₆H₂, etc.; W = OH; Z = H] under mild reaction conditions is presented. The trifluoromethoxylated products I [X = H; Y = 2-OCF₃, 4-OCF₃] and II [W = H; Z = OCF₃] are useful scaffolds that can be further elaborated by amidation and palladium-catalyzed cross coupling reactions. Mechanistic studies suggest that a radical O-trifluoromethylation followed by the OCF₃ -migration reaction pathway is operable. The unique properties of the OCF₃ group and the ubiquity of pyridine and pyrimidine in biol. active mols. and functional materials, trifluoromethoxylated pyridines I [X = H; Y = 2-OCF₃, 4-OCF₃] and pyrimidines II [W = H; Z = OCF₃] could serve as valuable building blocks for the discovery and development of new drugs, agrochems., and materials.

Chemical Science published new progress about 1448637-05-5. 1448637-05-5 belongs to esters-buliding-blocks, auxiliary class Alkynyl,Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is Methyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethynyl)benzoate, and the molecular formula is C22H23BO4, SDS of cas: 1448637-05-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Park, Seung Yeon published the artcileDimethyl itaconate attenuates palmitate-induced insulin resistance in skeletal muscle cells through the AMPK/FGF21/PPARδ-mediated suppression of inflammation, Application In Synthesis of 617-52-7, the publication is Life Sciences (2021), 120129, database is CAplus and MEDLINE.

Itaconate (ITA), a derivative of the tricarboxylic acid cycle, has been documented to have a direct antimicrobial effect by inhibiting isocitrate lyase and suppressing proinflammatory cytokines in LPS-treated macrophages. However, the effects of di-Me ITA (DITA), a membrane-permeable derivative of ITA, on insulin signaling and inflammation in skeletal muscle in an obese state remain to be elucidated. Thus, this study was designed to investigate the effects of DITA on the impairment of insulin signaling and inflammation in palmitate-treated C2C12 myocytes. Western blotting was used to determine the expression of insulin signaling associated genes, inflammatory markers, fibroblast growth factor 21 (FGF21), and PPARδ expression, as well as AMPK phosphorylation in mouse skeletal muscle cells. Secreted proinflammatory cytokine levels were detected by ELISA. Insulin signaling was assessed by glucose uptake assay. Treating C2C12 myocytes with DITA attenuated palmitate-induced aggravation of insulin signaling markers, such as insulin receptor substrate-1 (IRS-1) and Akt phosphorylation and inflammatory markers, such as NFκB and IκB phosphorylation. AMPK phosphorylation, as well as PPARδ and myokine FGF21 expression, were enhanced in C2C12 myocytes by DITA treatment. siRNA-mediated suppression of AMPK or FGF21 expression abolished the effects of DITA on insulin resistance and inflammation in palmitate-treated C2C12 myocytes. In sum, DITA suppresses inflammation through the AMPK/FGF21/PPARδ signaling, thereby alleviating insulin resistance in palmitate-treated C2C12 myocytes. The current study appears to be an essential basis for performing animal experiments to develop insulin resistance therapeutics.

Life Sciences published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Application In Synthesis of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Byun, Young Min published the artcileMechanical properties of carbon fiber-reinforced Al₂O₃ porous ceramics, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate, the publication is Journal of the Korean Ceramic Society (2021), 58(3), 269-275, database is CAplus.

This study reports the improvement of the mech. properties of Al₂O₃ porous ceramics from particle-stabilized colloidal suspension with the addition of carbon fiber through direct foaming. The initial colloidal suspension of Al₂O₃ was partially hydrophobized by a surfactant, Pr gallate (2 wt%), to stabilize the wet foam used with the addition of carbon fiber from 2 to 8 wt% as reinforcement. The influence of carbon fiber on the air content, bubble size, pore size, and pore distribution were discussed in terms of the wet foam stability and the phys. properties of the porous ceramics. The mech. properties of the sintered porous samples were investigated by the Hertzian indentation test. The results show that the wet foam stability of more than 90% corresponds to the compressive load bearing capacity of 110 N using tungsten carbide ball with a radius of r = 7.93 mm and the elastic modulus of 114.3 MPa in the sintered sample with 2 wt% of carbon content.

Journal of the Korean Ceramic Society published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kurz, Lilia published the artcileStereospecific functionalization of (R)-(-)-1,1′-bi-2-naphthol triflate, Quality Control of 126613-06-7, the publication is Tetrahedron Letters (1990), 31(44), 6321-4, database is CAplus.

Several examples of transition metal mediated functionalization of chiral 1,1′-bi-2-naphthol triflate are described which proceed with complete retention of substrate chirality. The transformations described demonstrate the potential of Pd(0) mediated reactions for the stereoselective transformation of the C-O bonds in this substrate.

Tetrahedron Letters published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Quality Control of 126613-06-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Huang, Lily published the artcileIdentification of Potent and Selective Mechanism-Based Inhibitors of the Cysteine Protease Cruzain Using Solid-Phase Parallel Synthesis, Recommanded Product: Ethyl 2-mercaptopropanoate, the publication is Journal of Medicinal Chemistry (2002), 45(3), 676-684, database is CAplus and MEDLINE.

Targeted libraries of ketone-based cysteine protease inhibitors were synthesized and screened against cruzain, a cysteine protease implicated in Chagas’ disease. A number of single digit nanomolar, low mol. weight inhibitors were identified and optimized for solubility and potency. Specifically, the best inhibitors identified have K_i values of 0.9-10 nM and mol. weights between 499 and 609 Da. The most effective inhibitor was also greater than 1000-fold selective for cruzain relative to cathepsin B and 100-fold selective for cruzain relative to cathepsin L.

Journal of Medicinal Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Recommanded Product: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lan, Jin published the artcileSelective synthesis of functionalized quinazolinone derivatives via biocatalysis, SDS of cas: 30414-53-0, the publication is Molecular Catalysis (2020), 111261, database is CAplus.

A novel and efficient biocatalyzed methodol. for the construction of functionalized quinazolinone derivatives via tandem / hydrolysis / decarboxylation / cyclization and transesterification reactions has been developed that works with a variety of 2-aminobenzamide and β-dicarbonyl compounds This method requires mild conditions, and has demonstrated high catalytic activity, excellent yields, excellent chemoselectivity, and a broad substrate scope. Addnl., biocatalyzed decarboxylation does not require high temperatures or light activation, giving it a substantial advantage over alternative techniques. Most importantly, it offers a new example for the exploration of simple, convenient, and environmentally friendly synthetic routes utilizing enzymes in organic chem.

Molecular Catalysis published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, SDS of cas: 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nguyen, Van Hai published the artcilePropyl gallate, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate, the publication is Molbank (2021), M1201, database is CAplus.

The title compound, Pr gallate (III), is an important substance popularly used in the food, cosmetic and pharmaceutical industries. Current chem. syntheses of this compound are based on the acylation supported by thionyl chloride, DIC/DMAP or Fischer esterification using a range of homogenous and heterogenous catalysts. In this paper, an efficient, green, straightforward, and economical method for synthesizing Pr gallate using potassium hydrogen sulfate, KHSO₄, as the heterogenous acidic catalyst has been developed for the first time. In addition, this paper provides a comprehensive spectral dataset for the title compound, especially the new data on DEPT and 2D NMR (HSQC and HMBC) spectra which are not currently available in the literature.

Molbank published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics