Month: December 2022

Haag, Franziska published the artcileThe key food odorant receptive range of broadly tuned receptor OR2W1, HPLC of Formula: 103-26-4, the publication is Food Chemistry (2022), 131680, database is CAplus and MEDLINE.

Mammals perceive a multitude of odorants by their chem. sense of olfaction, a high-dimensional stimulus-detection system, with hundreds of narrowly or broadly tuned receptors, enabling pattern recognition by the brain. Cognate receptor-agonist information, however, is sparse, and the role of broadly tuned odorant receptors for encoding odor quality remains elusive. Here, we screened IL-6-HaloTag-OR2W1 and haplotypes against 187 out of 230 defined key food odorants using the GloSensor system in HEK-293 cells, yielding 48 new agonists. Altogether, key food odorants represent about two-thirds of now 153 reported agonists of OR2W1, the highest number of agonists known for a mammalian odorant receptor. In summary, we characterized OR2W1 as a human odorant receptor, with a chem. diverse but exclusive receptive range, complementary to chem. subgroups covered by evolutionary younger, highly selective receptors. Our data suggest OR2W1 to be suited for participating in the detection of many foodborne odorants.

Food Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, HPLC of Formula: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jassem, Ahmed M. published the artcileMicrowave-assisted synthesis, molecular docking and anti-HIV activities of some drug-like quinolone derivatives, SDS of cas: 924-99-2, the publication is Medicinal Chemistry Research (2020), 29(6), 1067-1076, database is CAplus.

Abstract: In targeted therapy of breast cancer, human epidermal growth factor receptor 2 HER2 (PDB ID: 3PP0) is being considered as a promising route to design novel anti-breast cancer drugs. In this work, we report two of novel N-substituted pyrrolidine at C-8 position of quinolone derivatives 18 and 19, their synthesis under microwave technique, spectral methods, mol. docking study and anti-HIV activities. Docking study exhibited hydrogen bonding, polar, and Van der Waals interactions with the active site residues of HER2 target. The binding energy and hydrogen bonding interactions show that synthesized compounds are being considered to have a potential activity against breast cancer. In addition, quinolone derivatives were evaluated in vitro for antiviral activity against the replication of HIV-1 and HIV-2 in MT-4 cells. The results showed that quinolone derivatives 18 and 19 possess a potent activity against HIV-1 replication with IC₅₀ values of ≥15.20 and 14.26μM, SI ≤ 6 and >7, resp.

Medicinal Chemistry Research published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gautom, Trishnamoni published the artcileStructural basis of terephthalate recognition by solute binding protein TphC, Name: Potassium 4-nitrophenyl sulfate, the publication is Nature Communications (2021), 12(1), 6244, database is CAplus and MEDLINE.

Biol. degradation of Polyethylene terephthalate (PET) plastic and assimilation of the corresponding monomers ethylene glycol and terephthalate (TPA) into central metabolism offers an attractive route for bio-based mol. recycling and bioremediation applications. A key step is the cellular uptake of the non-permeable TPA into bacterial cells which has been shown to be dependent upon the presence of the key tphC gene. However, little is known from a biochem. and structural perspective about the encoded solute binding protein, TphC. Here, we report the biochem. and structural characterization of TphC in both open and TPA-bound closed conformations. This anal. demonstrates the narrow ligand specificity of TphC towards aromatic para-substituted dicarboxylates, such as TPA and closely related analogs. Further phylogenetic and genomic context anal. of the tph genes reveals homologous operons as a genetic resource for future biotechnol. and metabolic engineering efforts towards circular plastic bio-economy solutions

Nature Communications published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Name: Potassium 4-nitrophenyl sulfate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yadav, Kalpana published the artcileNano catalyzed Biginelli type reaction in green reaction media, HPLC of Formula: 30414-53-0, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2020), 59B(1), 102-109, database is CAplus.

Green chem. approach has been developed by using ionic liquid [MIM-H]CCl₃ (1-methyl-3-hydro-1H-imidazol-3-ium trichloromethanide) and TiO₂ nanoparticles (NPs) for the synthesis of 3,4-dihydropyrimidine-2(1H)-one (DHPMs) derivatives I (R¹ = Me, Et, n-Pr; R² = Me, Et, i-Pr, CH₂CH₂OMe; Ar = Ph, CH:CHC₆H₅, 5-Me-2-furyl).

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C7H8BNO4, HPLC of Formula: 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Leonhardt, B. A. published the artcileGas chromatographic mass spectrometric indication of double bond position in monounsaturated primary acetates and alcohols without derivatization, Formula: C14H26O2, the publication is Organic Mass Spectrometry (1983), 18(1), 9-11, database is CAplus.

Electron impact mass spectra of 54 straight chain, monounsaturated C₁₂, C₁₄, and C₁₆ alcs. and their corresponding acetates are useful in the determination of the double bond position on an empirical basis. The ratio of intensities of the m/z 55 and m/z 54 ions increases proportionately as the double bond is moved away from the acetate or alc. functional group. The intensity to the m/z 61 ion also can be correlated with the double bond position. Results are generally accurate to ±1 C atom.

Organic Mass Spectrometry published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Guan, Zhibin published the artcileFluorocarbon-Based Heterophase Polymeric Materials. 1. Block Copolymer Surfactants for Carbon Dioxide Applications, SDS of cas: 3052-61-7, the publication is Macromolecules (1994), 27(20), 5527-32, database is CAplus.

1,1-Dihydroperfluorooctyl acrylate (I) block copolymers were prepared for use as lipophilic surfactants for liquid CO₂ applications. Telechelic polystyrenes capped with N,N-diethyldithiocarbamate groups were prepared using the iniferter method. The functionalities of the telechelic polystyrene samples were analyzed by UV/vis, ¹H-NMR, and 3-D GPC. The 3-D GPC anal. provided detailed information on the functionality of end groups across the molar mass distribution. The block copolymers were prepared by subsequent polymerization of I using the telechelic polystyrene as macroinitiator. The chem. composition, the glass transition temperature, and solubility of the block copolymers were studied.

Macromolecules published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, SDS of cas: 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Randriamahefa, S. published the artcileImproved synthesis of tertiary alkylacetic acids and esters, SDS of cas: 5340-78-3, the publication is Synthesis (1985), 493-5, database is CAplus.

RR¹MeCCH₂CO₂H (R, R¹ = Me, Et) were prepared in 13-90% yield by treating CH₂:CCl₂ with RR¹MeCOH, H₂SO₄, and then H₂O. Similar treatment of CH₂:CCl₂ with Me₃COMe and Me₃CCl gave 55 and 77% Me₃CCH₂CO₂H resp. with some Me₃CCH₂CO₂Me also being formed when the ether was used. Addition of R²OH (R² = Me, Et, Pr, Me₂CH, Bu, Me₂CHCH₂, pentyl) to the reaction-mixture prior to H₂O yielded 13-76% RR¹CMeCH₂CO₂R².

Synthesis published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, SDS of cas: 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nantogmah, S. published the artcileSynthesis and preliminary evaluation of affinity to retinoic acid receptors for new organosilicon-based retinoids, Application In Synthesis of 50670-76-3, the publication is Pharmaceutical Chemistry Journal (2012), 45(10), 612-621, database is CAplus.

Two facile synthetic routes to eleven new Si-containing ligands for retinoic acid receptors (RARs) are reported. The design of these RAR ligands is based on a pharmacophoric model that divides the mols. into three regions that are necessary for efficient binding to the corresponding receptors: a hydrophobic region (A), a linker or tether region (B) and a hydrophilic region (C). The ligands are unique in region A due to their acyclic nature and the presence of alkyl-substituted Si at the core. The substituted silyl groups were used to fulfill pharmacophore requirements. Various alkyl substituents available on the Si starting materials afford an opportunity to explore steric effects on binding. In region B of four ligands, a cinnamate moiety maintains some degree of conjugation and planarity in the mols. A biaryl group used in region B of another series of compounds is known to lead to RARb selectivity. Finally, region C of the ligands contains a carboxylate group, a well known pharmacophore requirement for RAR ligands. The compounds prepared in this work have micromolar to nanomolar affinity for these medically relevant target receptors. The proposed silane-containing ligands represent siloacetylenic aryl acids that are worth of further study. They may serve as leads for the development of higher-affinity, more receptor-selective agents.

Pharmaceutical Chemistry Journal published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Application In Synthesis of 50670-76-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Yang published the artcileElectrochemically Promoted Nickel-Catalyzed Carbon-Sulfur Bond Formation, Synthetic Route of 19788-49-9, the publication is ACS Catalysis (2019), 9(3), 1630-1634, database is CAplus.

This work describes a nickel-catalyzed Ullmann-type thiolation of aryl iodides under mild electrochem. conditions. The simple undivided cell with graphite felt/nickel foam electrode setups offers excellent substrate tolerance, affording aryl and alkyl sulfides in good chem. yields. Furthermore, the mechanism for this electrochem. cross-coupling reaction has been investigated by cyclic voltammetry.

ACS Catalysis published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C6H6N2O, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lu, Hongyu published the artcileSynergistic degradation of fluorene in soil by dielectric barrier discharge plasma combined with P25/NH₂-MIL-125(Ti), HPLC of Formula: 624-49-7, the publication is Chemosphere (2022), 133950, database is CAplus and MEDLINE.

Plasma techniques to degrade pollutants are generally more efficient than conventional methods, but exist some problems such as high energy consumption, incomplete degradation of pollutants, and secondary pollution caused by highly toxic intermediates. In this study, the dielec. barrier discharge plasma (DBDP) combined with the Ti-based metal organic frameworks (MOFs) catalysts (P25/NH₂-MIL-125(Ti)) was used to degrade fluorene in the soil. The synergistic treatment technique used in soil remediation can realize a green and promising treatment efficiency with relatively low energy consumption. Compared with DBDP system alone, the synergetic treatment system of DBDP and P25/NH₂-MIL-125(Ti) considerably increased the degradation efficiency of fluorene in the soil to above 90% at 10 min, even with a relatively low discharge voltage (5 kV). The synergistic treatment system achieved 88.8% of fluorene mineralization at 60 min. Optical emission spectroscopy and ESR spectroscopy both showed that •OH and •O₂^– played an important role in the synergetic treatment system. Nine main intermediates were identified using gas chromatog.-mass spectrometry and Fourier transform IR anal. The main degradation of fluorine in soil was caused by the electronic transition of the catalytic material excited by DBDP, and finally mineralized into CO₂ and H₂O. The fluorene and its toxic intermediates were effectively removed. This study provides an insight for achieving high efficiency and environmentally friendly application perspective in soil remediation.

Chemosphere published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, HPLC of Formula: 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics