Month: December 2022

Water-soluble esters: useful enzyme substrates for the synthesis of β-lactam antibiotics was written by Muneyuki, Ryonosuke;Mitsugi, Takashi;Kondo, Eiji. And the article was included in Chemistry & Industry (London, United Kingdom) in 1981.Application of 19432-68-9 This article mentions the following:

Water-soluble thienyl and aromatic esters acylated β-lactam amines in the presence of 3 enzymes. E.g., I, prepared by treating RCH₂CO₂Me (R = 2-thienyl) with H(OCH₂CH₂)₄OH and K₂CO₃ (60°, 70 mm Hg, 3 h), with II (R¹ = H) in the presence of Bacillus circulans M-1123-5 gave 49.6% II (R¹ = 2-thienylacetyl). In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Application of 19432-68-9).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 19432-68-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Influence of apricot constituents as eco-friendly corrosion inhibitor for mild steel in acidic medium: A theoretical approach was written by Khadom, Anees A.;Jassim, Salah A.;Kadhim, Mustafa M.;Ali, Nabaa B.. And the article was included in Journal of Molecular Liquids in 2022.COA of Formula: C12H20O2 This article mentions the following:

The corrosion prevention mechanism of steel by apricot juice as green chems. was better understood using mol. dynamics and quantum chem. simulations. Furthermore, math. and statistical anal. were a powerful tool for building a relationship between inhibitor performance and independent variables. Eighteen main compounds of apricot juice were investigated using quantum chem. calculations HOMO energy, LUMO energy, energy gap, chem. hardness, electrophilicity index, softness, and back donation were calculated as identifications parameters. Caffeic acid, beta-cyclocitral and gallic acid were observed as the most potent inhibitors between all the studied components. In addition, docking studies were applied to present the interactions with A.ferrooxidans bacteria that caused the corrosion. Math. model, with good correlation coefficient, was designed to link quantum chem. characteristics to theor. inhibitory efficiency (%IEcal). Theor. data were compared with exptl. one (%IEexp). %IEexp was ranged from 53 to 75%, while the %IEcal was ranged from 61 to 73%. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3COA of Formula: C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C12H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Click chemistry-based synthesis and cytotoxic activity evaluation of 4α-triazole acetate podophyllotoxin derivatives was written by Hou, Wei;Zhang, Guanjun;Luo, Zhi;Su, Lin;Xu, Hongtao. And the article was included in Chemical Biology & Drug Design in 2019.Application In Synthesis of tert-Butyl (3-ethynylphenyl)carbamate This article mentions the following:

A series of novel 4α-triazole acetate podophyllotoxin derivatives were synthesized via click chem. In vitro cytotoxic activity evaluation showed that most of the derivatives exhibited potent inhibitory activities against the tested cancer cell lines with low nanomolar IC₅₀ values. Further studies demonstrated that compound I exhibited broad-spectrum cytotoxic activities, effectively overcame drug-resistance, and showed relatively weak cytotoxicity on non-cancer cells. Preliminary mechanistic studies indicated that I might have action on microtubule, cause cell cycle arrest at G₂/M phase, and induce apoptosis in human PC-3 cancer cells. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3Application In Synthesis of tert-Butyl (3-ethynylphenyl)carbamate).

tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of tert-Butyl (3-ethynylphenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Functionalization and patterning of reactive polymer brushes based on surface reversible addition and fragmentation chain transfer polymerization was written by Choi, Jiyeon;Schattling, Philipp;Jochum, Florian D.;Pyun, Jeffrey;Char, Kookheon;Theato, Patrick. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2012.Related Products of 27249-90-7 This article mentions the following:

We present the synthesis of reactive polymer brushes prepared by surface reversible addition-fragmentation chain transfer polymerization of pentafluorophenyl acrylate. The reactive ester moieties can be used to functionalize the polymer brush film with virtually any functionality by simple post-polymerization modification with amines. Dithiobenzoic acid benzyl-(4-ethyltrimethoxylsilyl) ester was used as the surface chain transfer agent (S-CTA) and the anchoring group onto the silicon substrates. Reactive polymer brushes with adjustable mol. weight, high grafting d., and conformal coverage through the grafting-from approach were obtained. Subsequently, the reactive polymer brushes were converted with amino-spiropyrans resulting in reversible light-responsive polymer brush films. The wetting behavior could be altered by irradiation with UV or visible light. Furthermore, a patterned surface of polymer brushes was obtained using a lithog. technique. UV irradiation of the S-CTA-modified substrates leads to a selective degradation of S-CTA in the exposed areas and gives patterned activated polymer brushes after a subsequent RAFT polymerization step. Conversion of the patterned polymer brushes with 5-((2-aminoethyl)amino)naphthalene-1-sulfonic acid resulted in patterned fluorescent polymer brush films. The utilization of reactive polymer brushes offers an easy approach in the fabrication of highly functional brushes, even for functionalities whose introduction is limited by other strategies. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Related Products of 27249-90-7).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 27249-90-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Asymmetric Synthesis of Netarsudil: A New Therapeutic for Open-Angle Glaucoma was written by deLong, Mitchell A.;Sturdivant, Jill M.. And the article was included in Synthesis in 2019.Name: Methyl 2-(4-(hydroxymethyl)phenyl)acetate This article mentions the following:

The asym. synthesis of a Rho kinase/norepinephrine transport inhibitor, netarsudil, the active component in the recently FDA-approved product Rhopressa, is described herein. This concise six-step synthetic route utilizes the 2,4-dimethylbenzoate ester of a phenylacetic acid as the backbone of the β-amino acid’s framework. A chiral enolate of the Evans auxiliary, ( R)-4-benzyloxazolidin-2-one, is used to direct the formation of the ( S)-stereocenter by incorporating the N-Boc-protected β-amino Me arm with high diastereoselectivity (96:4 dr) using N-Boc-1-(aminomethyl)benzotriazole as the electrophile. Uniquely, 2,2,2-trichloro-1,1-dimethylethyl chloroformate is used as a non-racemizing activating agent for the coupling reaction between the chiral (S)-3-[(tert-Butoxycarbonyl)amino]-2-(4-{[(2,4-dimethylbenzoyl)oxy]methyl}phenyl)propanoic acid and 6-aminoisoquinoline to provide N-Boc-protected netarsudil in good yield and excellent enantiomeric purity (63%, 98% ee). Final acidic deprotection and recrystallization provides netarsudil (>99% ee), an ophthalmic agent used for the treatment of patients with open-angle glaucoma. In the experiment, the researchers used many compounds, for example, Methyl 2-(4-(hydroxymethyl)phenyl)acetate (cas: 155380-11-3Name: Methyl 2-(4-(hydroxymethyl)phenyl)acetate).

Methyl 2-(4-(hydroxymethyl)phenyl)acetate (cas: 155380-11-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: Methyl 2-(4-(hydroxymethyl)phenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of polyorganophosphazenes and fabrication of their blend microspheres and micro/nanofibers as drug delivery systems was written by Ullah Khan, Rizwan;Wang, Li;Yu, Haojie;Zain-Ul-Abdin;Haq, Fazal;Haroon, Muhammad;Naveed, Kaleem-Ur-Rehman;Elshaarani, Tarig;Fahad, Shah;Ren, Sicong;Wang, Jun. And the article was included in International Journal of Polymeric Materials and Polymeric Biomaterials in 2020.Formula: C9H10O3 This article mentions the following:

Four amino acid-based polyorganophosphazenes were synthesized and characterized by ¹H NMR, ³¹P NMR and GPC. Individually, the synthesized polyorganophosphazenes were blended with two commonly used biocompatible polymers, poly (Me methacrylate) (PMMA) and polylactic-co-glycolic acid (PLGA) to fabricate anticancer drug loaded micro/nanofibers and microspheres. The nature of side groups, blend composition and drug contents were particularly found significant to adjust the surface morphol., hydrolytic degradation and drug loading/release behavior of microspheres. Moreover, higher in vitro drug release rate was observed in acidic medium. Collectively, our findings suggest that amino acid-based polyorganophosphazenes blend’ systems may provide a therapeutic strategy for cancers. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Formula: C9H10O3).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Formula: C9H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vaporization/sublimation enthalpies of mono- and dimethyl-esters estimated by solution calorimetry method was written by Samatov, Aizat A.;Nagrimanov, Ruslan N.;Miroshnichenko, Evgeniy A.;Solomonov, Boris N.. And the article was included in Thermochimica Acta in 2020.Formula: C12H22O4 This article mentions the following:

The additive scheme for calculating the solvation enthalpies of aliphatic compounds has been developed for linear mono- and dimethyl-esters. Ester group contribution to the enthalpy of solvation in n-heptane was obtained. Accuracy of the proposed approach for determination of solvation enthalpies of linear mono- and dimethyl-esters was tested by comparison with exptl. solvation enthalpies. In most cases, deviations do not exceed 1 kJ·mol^-1. It was found that the dependence of the solution enthalpies of mono- and dimethyl-esters on the number of carbon atoms in the mol. can be fitted by power function. This dependence and a group-additivity scheme for solvation enthalpy were used for estimation of the enthalpies of phase transitions of mono- and dimethyl-esters. Evaluated values of sublimation, vaporization, and fusion enthalpies at 298.15 K are in good agreement with exptl. data obtained by conventional methods. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Formula: C12H22O4).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C12H22O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rh(III)-Catalyzed C(7)-H Alkylation of Quinolines in the Synthesis of Angular π-Extended Pyrroloquinolines for Single-Component White-Light Emission was written by Khot, Nandkishor Prakash;Mahato, Paritosh;Sajeev, T. K.;Mukherjee, Saptarshi;Kapur, Manmohan. And the article was included in Organic Letters in 2022.Category: esters-buliding-blocks This article mentions the following:

Reported herein is a sustainable approach for a regioselective Rh(III)-catalyzed C(7)-H alkylation of 8-aminoquinolines via metal carbene migratory insertion. This transformation displays a high functional group tolerance and exquisite site selectivity to afford the C-7 alkylated products I [R¹ = H, 2-Me, 3-Br, etc., R² = Me, Et, Ar = Ph, 4-FC₆H₄, 2-furyl, etc.]. These products were derivatized to afford π-extended angular pyrroloquinolines II [R³ = H, Me, R⁴ = H, 7-(4-HOC₆H₄), 7-(4-MeOC₆H₄), Ar¹ = Ph, 3-FC₆H₄, 2-thienyl, etc.], one of which, II [R³ = R⁴ = H, Ar = 2-thienyl], showed white-light emission (WLE) with CIE coordinates (0.26, 0.34). An excellent cell viability and in vivo cellular imaging substantiated the nontoxic nature of these compounds In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Category: esters-buliding-blocks).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electrochemical two-electron oxygen reduction reaction (ORR) induced aerobic oxidation of α-diazoesters was written by Ruan, Mengyao;Chen, Liang;Wen, Ziyang;Yang, Fan;Ma, Chao;Lu, Cuifen;Yang, Guichun;Gao, Meng. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Recommanded Product: 587-88-2 This article mentions the following:

The recent progress in the oxidation of α-diazoesters R¹C(=N₂)C(O)OR² (R¹ = Ph, 2-naphthyl, benzo[d][1,3]dioxol-5-yl, etc.; R² = Me, cyclohexyl, (tetrahydrofuran-2-yl)methyl, etc.) to α-ketoesters R¹C(O)C(O)OR² by in situ generated hydrogen peroxide via a two-electron oxygen reduction approach was described. A diverse collection of valuable α-ketoester products was obtained with moderate to high yields under an exogenous-oxidant-free and metal catalyst-free electrochem. conditions. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Recommanded Product: 587-88-2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 587-88-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phthalate diversity in eggs and associations with oxidative stress in the European herring gull (Larus argentatus) was written by Allen, Simon F.;Ellis, Francesca;Mitchell, Christopher;Wang, Xianyu;Boogert, Neeltje J.;Lin, Chun-Yin;Clokey, Joseph;Thomas, Kevin V.;Blount, Jonathan D.. And the article was included in Marine Pollution Bulletin in 2021.Electric Literature of C20H26O4 This article mentions the following:

Phthalates are plastic-derived contaminants that are ubiquitous in natural environments and function as pro-oxidants. The extent to which phthalates bioaccumulate in wild animals and associations with oxidative stress are poorly understood. Here, we describe relationships between maternally-derived phthalates, lipid peroxidation (malondialdehyde, MDA) and the dietary antioxidant α-tocopherol in eggs of European herring gulls (Larus argentatus) in Cornwall, UK. Up to six phthalate parent compounds and four phthalate metabolites were detected. Egg concentrations of MDA were pos. associated with dicyclohexyl phthalate (DCHP) and neg. associated with α-tocopherol, suggesting that DCHP is associated with oxidative stress in gulls. The consequences of phthalate exposure in ovo for offspring development warrants study. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Electric Literature of C20H26O4).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C20H26O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics