Month: December 2022

Parmar, Hamendra Singh published the artcileCross Talk between COVID-19 and Breast Cancer, COA of Formula: C12H9N3O5S, the main research area is review COVID19 prognosis breast cancer; ACE-2 receptors; Cytokine storm; DPP-IV.; TMPRSS2; breast cancer; diabetes.

Cancer patients are more susceptible to COVID-19; however, the prevalence of COVID-19 in different types of cancer is still inconsistent and inconclusive. Here, we delineate the intricate relationship between breast cancer and COVID-19. Breast cancer and COVID-19 share the involvement of common comorbidities, hormonal signalling pathways, gender differences, rennin- angiotensin system (RAS), angiotensin-converting enzyme-2 (ACE-2), transmembrane protease serine 2 (TMPRSS2) and dipeptidyl peptidase-IV (DPP-IV). We also shed light on the possible effects of therapeutic modalities of COVID-19 on breast cancer outcomes. Briefly, we conclude that breast cancer patients are more susceptible to COVID-19 in comparison with their normal counterparts. Women are more resistant to the occurrence and severity of COVID-19. Increased expressions of ACE2 and TMPRSS2 are correlated with occurrence and severity of COVID-19, but higher expression of ACE2 and lower expression of TMPRSS2 are prognostic markers for overall disease free survival in breast cancer. The ACE2 inhibitors and ibuprofen therapies for COVID-19 treatment may aggravate the clin. condition of breast cancer patients through chemo-resistance and metastasis. Most of the available therapeutic modalities for COVID-19 were also found to exert pos. effects on breast cancer outcomes. Besides drugs in clin. trend, TMPRSS2 inhibitors, estrogen supplementation, androgen deprivation and DPP-IV inhibitors may also be used to treat breast cancer patients infected with SARS-CoV-2. However, drug-drug interactions suggest that some of the drugs used for the treatment of COVID-19 may modulate the drug metabolism of anticancer therapies which may lead to adverse drug reaction events.

Current Cancer Drug Targets published new progress about Androgens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, COA of Formula: C12H9N3O5S.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rajina, M. published the artcileEfficacy of e-beam irradiation on shelf-life and accompanied changes in major metabolites of Desmodium gangeticum (L.) DC., an Ayurveda medicinal plant, Application of Methyl docosanoate, the main research area is Desmodium root methanol extract electron irradiation neophytadiene antioxidant activity.

The effects of electron beam irradiation (5, 10 and 15 kGy) on shelf-life and major plant metabolites of an Ayurvedic medicinal plant Desmodium gangeticum was evaluated. Its root possesses incredible medicinal effects; hence powd. root sample (choorna) was subjected to radiation processing and thereby shelf-life extension. The root sample was found to possess an appreciable amount of phenolic and flavonoid compounds TPC of untreated sample was completely deteriorated during storage. Flavonoids of untreated sample were depleted almost completely after a shelf-life of 12 mo. TFC of all the irradiated samples also decreased significantly (p<0.05) under storage. Irradiated and control samples were found to possess adequate amount amounts of minerals. Electron beam irradiation with dose of 5 kGy and 15 kGy significantly decreased nitrogen and magnesium levels. In contrast, Calcium content was increased significantly (p < 0.05) on radiation processing wit 5 kGy and 15 kGy. Microbial status revealed that the untreated sample was acceptable only up to 4 mo. A dose-dependent reduction in the microbial count resulted in all the radiation processed samples. Treatment with doses of 10 kGy and 15 kGy reduced the colony count to nil immediately after irradiation Irradiation with 15 kGy kept the sample completely sterilized up to 2 mo of storage and was acceptable even 12th month of storage. GCMS analyses identified compounds with pharmacol. importance such as Me palmitate, mome-inositol, Neophytadiene, etc. Although, a slight change in mineral composition and phytochems. were observed it could effectively decontaminate the medicinal herb and increase the shelf-life with min. loss of major metabolites compared to other conventional methods of processing. International Journal of Research in Pharmaceutical Sciences (Madurai, India) published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Application of Methyl docosanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haida, S. published the artcileChemical composition, phenolic content and antioxidant capacity of Haloxylon scoparium extracts, Application In Synthesis of 929-77-1, the main research area is Haloxylon scoparium extract chem composition phenolic content antioxidant capacity.

This work is part of the valorization of the Haloxylon scoparium plant, belonging to the Chenopodiaceae family and native to southeastern of Morocco. The aim of the present work is to study the chem. composition of this plant, to estimate the phenolic compounds contents of its extracts and to evaluate their antioxidant powers. After extraction by maceration of the aerial and root part of Haloxylon scoparium, the extracts obtained are fractionated by liquid-liquid extraction using solvents of different polarities. The best extraction yield is obtained in the aerial part 23.54% against 10.99% for the root part. The anal. carried out by the coupling of gas chromatog. with mass spectrometry (GC-MS) shows that the root part contains mainly carbohydrates, however the aerial part consists mainly of alkaloids. The total polyphenol content obtained in the root part 69.86 mg/gEAG (mg/g of gallic acid) is significantly higher than that in the aerial part 56.79 mg/g EAG. The hydrolysable tannins are the predominant polyphenols of the root part of Haloxylon scoparium corresponding to 83.87 mg/g EAT (mg/g of tannic acid). The antioxidant activity of the various extracts obtained is evaluated by two methods: the DPPH (1,1-diphenyl-2-picryl hydrazyl) free radical scavenging test and the ferric reducing antioxidant power (FRAP). The examination of the inhibitory concentration values shows that the butanolic extract of the root part is the most active with values of IC50 = 0.06 mg/mL and IC0.5 = 0.19 mg/mL resp. for the DPPH and FRAP tests. The other extracts also showed a very interesting potential as antioxidants.

South African Journal of Botany published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Application In Synthesis of 929-77-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haida, S. published the artcileChemical composition, phenolic content and antioxidant capacity of Haloxylon scoparium extracts, Product Details of C11H22O2, the main research area is Haloxylon scoparium extract chem composition phenolic content antioxidant capacity.

This work is part of the valorization of the Haloxylon scoparium plant, belonging to the Chenopodiaceae family and native to southeastern of Morocco. The aim of the present work is to study the chem. composition of this plant, to estimate the phenolic compounds contents of its extracts and to evaluate their antioxidant powers. After extraction by maceration of the aerial and root part of Haloxylon scoparium, the extracts obtained are fractionated by liquid-liquid extraction using solvents of different polarities. The best extraction yield is obtained in the aerial part 23.54% against 10.99% for the root part. The anal. carried out by the coupling of gas chromatog. with mass spectrometry (GC-MS) shows that the root part contains mainly carbohydrates, however the aerial part consists mainly of alkaloids. The total polyphenol content obtained in the root part 69.86 mg/gEAG (mg/g of gallic acid) is significantly higher than that in the aerial part 56.79 mg/g EAG. The hydrolysable tannins are the predominant polyphenols of the root part of Haloxylon scoparium corresponding to 83.87 mg/g EAT (mg/g of tannic acid). The antioxidant activity of the various extracts obtained is evaluated by two methods: the DPPH (1,1-diphenyl-2-picryl hydrazyl) free radical scavenging test and the ferric reducing antioxidant power (FRAP). The examination of the inhibitory concentration values shows that the butanolic extract of the root part is the most active with values of IC50 = 0.06 mg/mL and IC0.5 = 0.19 mg/mL resp. for the DPPH and FRAP tests. The other extracts also showed a very interesting potential as antioxidants.

South African Journal of Botany published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Product Details of C11H22O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Pengjie published the artcileChanges in Non-Volatile and Volatile Metabolites Associated with Heterosis in Tea Plants (Camellia sinensis), Category: esters-buliding-blocks, the main research area is Camellia heterosis metabolome; Camellia sinensis; heterosis; hybrid; volatiles; widely targeted metabolomics.

Heterosis or hybrid vigor is extensively used in plant breeding. However, the contribution of metabolites to heterosis is still elusive. Here, we systematically identified the non-volatile and volatile metabolites of two hybrids and their parents in Camellia sinensis. The metabolomics anal. showed prevalent non-additive accumulation in hybrids, among which the non-additive nucleotides, alkaloids, organic acids, and tannins contribute to the pos. heterosis of hybrids, including typical inosine, guanosine, adenosine, caffeine, succinic acid, adipic acid, xylonic acid, and gallic acid. The catechins and free amino acids in hybrids showed neg. heterosis compared to its maternal cultivar TGY. Furthermore, the significant accumulation of non-additive terpenes combined with the mild heterosis of other types of volatiles contributes to the aroma of tea plant hybrids. The genetics of volatiles from different parents affect the aroma of hybrids processed into oolong tea. The comprehensive heterosis of these non-additive metabolites may play an important role in the formation of desirable breeding traits for hybrids. Our results provide insights into the utilization of heterosis breeding and the regulation of heterosis metabolites in tea plants.

Journal of Agricultural and Food Chemistry published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Zhibin published the artcileDynamic changes of volatile and phenolic components during the whole manufacturing process of Wuyi Rock tea (Rougui), Quality Control of 140-11-4, the main research area is Wuyi Rock tea phenolics leaf alkaloids Maillard reaction flavor; Dynamic changes; Manufacturing process; Morphology; Phenolic compounds; Volatile compounds; Wuyi Rock tea.

Wuyi Rock tea (WRT), a top-ranking oolong tea, possesses characteristic woody, floral, nutty flavor. WRT flavor is mainly formed during the manufacturing process. However, details regarding its formation process are not fully understood yet. In this study, the dynamics of volatile and phenolic components over the whole manufacturing process of WRT were investigated. During withering, despite minor changes in volatile and phenolic components, the central vacuole shrunk remarkably, which reduced the cell mech. performance and facilitated the subsequent enzymic fermentation During fermentation, approx. 78% of flavan-3-ols in fresh tea leaves were oxidized and converted to a diverse mixture of highly heterogeneous oxidation products, such as theaflavins, whereas flavonols, phenolic acids, and xanthine alkaloids remained stable throughout the manufacturing process. Aldehydes, ketones, and heterocyclic compounds, imparting woody, floral, and nutty scent, were mainly formed during the roasting steps. This detailed information can expand our understanding on the formation of WRT flavor.

Food Chemistry published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Quality Control of 140-11-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahmed, Maqsood published the artcilePhytochemical analysis, biochemical and mineral composition and GC-MS profiling of methanolic extract of Chinese arrowhead Sagittaria trifolia L. from Northeast China, Safety of Methyl octanoate, the main research area is Sagittaria phytoconstituent biochem mineral composition GC MS Northeast China; DPPH; Sagittaria trifolia; biochemical composition; phenol and flavonoids content; phytochemicals.

Sagittaria trifolia is a medicinal foodstuff of China and East Asia belonging to the family Alismataceae. The current study was aimed to evaluate the qual. and quant. anal., antioxidant activity, biochem. anal. and chem. composition of different populations of S. trifolia. By using Folin-Ciocalteu, aluminum chloride colorimetric and 1,1-diphenyl-1-picrylhydrazyl (DPPH), total phenol and flavonoids content and antioxidant activity was analyzed. Furthermore, chem. composition, biochem. anal. and mineral substances were also determined The results showed the presence of flavonoids, phenols, saponins, tannins, glycosides and steroids except for alkaloids and terpenoids by qual. anal. Quant. anal. revealed that highest total phenol, flavonoids content and antioxidant potential identified from Meihekow, i.e., 2.307 mg GAE/g, 12.263 mg QE/g and 77.373%, resp. Gas chromatog.-mass spectrometry results showed the presence of 40 chem. compounds corresponding to 99.44% of total extract that might be responsible for antioxidant properties. Mineral and biochem. anal. revealed the presence of calcium, magnesium, potassium, sodium, iron, copper, zinc and, carbohydrate, protein, fiber and fat contents, resp. Interestingly, all S. trifolia populations collected from different locations possess similar composition The dietary values, phytoconstituents, antioxidant activities and nutritional and curative chem. compounds of S. trifolia are beneficial for the nutritherapy of human beings.

Molecules published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, Safety of Methyl octanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mogle, Prashant P. published the artcileThiazole derivatives containing compounds as curative agents for tuberculosis: a review, Computed Properties of 55981-09-4, the main research area is review tuberculosis thiazole derivative compound curative agent.

Tuberculosis disease is the second main cause of deaths worldwide & become more dangerous because of increasing resistance towards novel anti-tubercular agents. In the last few decades, the number of development & research acomplished for the synthesis and biol. studies of novel anti-tubercular agents. Among heterocycles, thiazole is a versatile building block useful in the field of medicinal chem. Recently these compounds used for lead generation of future anti-tubercular agents having high effectiveness, potent anti-tubercular activity & possessing less toxicity. In this review, our focal point is to investigate the recent developments in the synthesis of thiazole derivatives & evaluate their biol. importance in anti-tubercular drug discovery. This review accessible for researchers which involves the rational designing of more potent anti-tubercular drugs containing thiazole moiety.

Heterocyclic Letters published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, Computed Properties of 55981-09-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pandey, Avantika published the artcileUltraviolet-B mediated biochemical and metabolic responses of a medicinal plant Adhatoda vasica Nees. at different growth stages, Category: esters-buliding-blocks, the main research area is Adhatoda vasica medicinal plant growth UV biochem metabolic pathway; Adhatoda vasica; Antioxidants; Metabolic profile; Secondary metabolites; UV-B.

In the present study, the effects of elevated UV-B (eUV-B; ambient ± 7.2 kJ m-2 day-1) were evaluated on the biochem. and metabolic profile of Adhatoda vasica Nees. (an indigenous medicinal plant) at different growth stages. The results showed reduction in superoxide radical production rate, whereas increase in the content of hydrogen peroxide which was also substantiated by the histochem. localization. Malondialdehyde content, which is a measure of oxidative stress, did not show significant changes at any of the growth stages however photosynthetic rate and chlorophyll content showed reduction at all growth stages under eUV-B exposure. Increased activities of the enzymic and non-enzymic antioxidants were noticed except ascorbic acid, which was reduced under eUV-B exposure. The metabolic profile of A. vasica revealed 43 major compounds (assigned under different classes) at different growth stages. Triterpenes, phytosterols, unsaturated fatty acids, diterpenes, tocopherols, and alkaloids showed increment, whereas reduction in saturated fatty acids and sesquiterpenes were observed under eUV-B treatment. Vasicinone and vasicoline, the two important alkaloids of A. vasica, showed significant induction under eUV-B exposure as compared to control. Treatment of eUV-B leads to the synthesis of some new compounds, such as oridonin oxide (diterpene) and α-Bisabolol oxide-B (sesquiterpene), which possess potent anti-inflammatory and anticancerous activities. The study displayed that differential crosstalk between antioxidants and secondary metabolites at different growth stages, were responsible for providing protection to A. vasica against eUV-B induced oxidative stress and enhancing its medicinal properties.

Journal of Photochemistry and Photobiology, B: Biology published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Saxena, Shaiphali published the artcilePharmacological and phytochemical assessment of Anagallis arvensis L. leaf extracts, SDS of cas: 929-77-1, the main research area is Anagallis arvensis leaf extract phytochem pharmacol assessment.

The present study elucidates anti-inflammatory potential and biochem. activity via 2,2′-diphenyl-1-picrylhydrazyl scavenging potential (DPPH), total antioxidant activity (TAA), ferric reducing antioxidant power (FRAP), ferrous chelating activity (FCA), total phenolic content (TPC), total flavonoid content (TFC) of aqua-methanol (AqM) and aqua-acetone (AqA) extracts of Anagallis arvensis L. leaf along with mineral content (AAS) and quant. phytochems. (FT-IR and GC-MS). AqM extract exhibited maximum anti-inflammatory activity (82.90 ± 0.91%), DPPH (65.06 ± 1.87%), TAA (46.85 ± 7.32 μg VCE/mg), FRAP (73.82 ± 1.21 μg TE/mg), TPC (104.17 ± 1.41 μg GAE/mg); while AqA showed maximum FCA (64.77 ± 1.61%) and TFC (19.12 ± 1.24 μg QE/mg). FT-IR spectra of AqM extract ranged from 1020.58 to 3853.42 cm-1. The major six phytochems. investigated through GC-MS were 9-octadecenoic acid (Z)-methylester; 2-hexadecen-1-ol-3,7,11,15-tetramethyl-[R-[R*,R*-(E)]]; Me elaidate; 2-methoxy-4-vinylphenol; 9-octadecenamide-(Z)-; and benzoic acid 2-hydroxy-phenylmethyl ester exhibiting antioxidant and anti-inflammatory properties. The present investigation characterizes the pharmacognostic and phytochem. profile of A. arvensis leading towards its futuristic significance in pharmaceutical and nutraceutical industries.

Asian Journal of Chemistry published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, SDS of cas: 929-77-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics