Month: December 2022

Hua, My published the artcileIdentification of Cytotoxic Flavor Chemicals in Top-Selling Electronic Cigarette Refill Fluids, Formula: C9H10O2, the main research area is epithelial cell flavor chem electronic cigarette refill fluid cytotoxicity.

We identified the most popular electronic cigarette (EC) refill fluids using an Internet survey and local and online sales information, quantified their flavor chems., and evaluated cytotoxicities of the fluids and flavor chems. “”Berries/Fruits/Citrus”” was the most popular EC refill fluid flavor category. Twenty popular EC refill fluids were purchased from local shops, and the ingredient flavor chems. were identified and quantified by gas chromatog.-mass spectrometry. Total flavor chem. concentrations ranged from 0.6 to 27.9 mg/mL, and in 95% of the fluids, total flavor concentration was greater than nicotine concentration The 20 most popular refill fluids contained 99 quantifiable flavor chems.; each refill fluid contained 22 to 47 flavor chems., most being esters. Some chems. were found frequently, and several were present in most products. At a 1% concentration, 80% of the refill fluids were cytotoxic in the MTT assay. Six pure standards of the flavor chems. found at the highest concentrations in the two most cytotoxic refill fluids were effective in the MTT assay, and ethyl maltol, which was in over 50% of the products, was the most cytotoxic. These data show that the cytotoxicity of some popular refill fluids can be attributed to their high concentrations of flavor chems.

Scientific Reports published new progress about Cytotoxicity. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Formula: C9H10O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hua, My published the artcileIdentification of Cytotoxic Flavor Chemicals in Top-Selling Electronic Cigarette Refill Fluids, Quality Control of 123-29-5, the main research area is epithelial cell flavor chem electronic cigarette refill fluid cytotoxicity.

We identified the most popular electronic cigarette (EC) refill fluids using an Internet survey and local and online sales information, quantified their flavor chems., and evaluated cytotoxicities of the fluids and flavor chems. “”Berries/Fruits/Citrus”” was the most popular EC refill fluid flavor category. Twenty popular EC refill fluids were purchased from local shops, and the ingredient flavor chems. were identified and quantified by gas chromatog.-mass spectrometry. Total flavor chem. concentrations ranged from 0.6 to 27.9 mg/mL, and in 95% of the fluids, total flavor concentration was greater than nicotine concentration The 20 most popular refill fluids contained 99 quantifiable flavor chems.; each refill fluid contained 22 to 47 flavor chems., most being esters. Some chems. were found frequently, and several were present in most products. At a 1% concentration, 80% of the refill fluids were cytotoxic in the MTT assay. Six pure standards of the flavor chems. found at the highest concentrations in the two most cytotoxic refill fluids were effective in the MTT assay, and ethyl maltol, which was in over 50% of the products, was the most cytotoxic. These data show that the cytotoxicity of some popular refill fluids can be attributed to their high concentrations of flavor chems.

Scientific Reports published new progress about Cytotoxicity. 123-29-5 belongs to class esters-buliding-blocks, name is Ethyl nonanoate, and the molecular formula is C11H22O2, Quality Control of 123-29-5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wee, Chan Woo published the artcileNewly synthesized DNA methyltransferase inhibitors as radiosensitizers for human lung cancer and glioblastoma cells, Category: esters-buliding-blocks, the main research area is glioblastoma cell DNA methyltransferase inhibitor radiosensitizer; DNA methyltransferase; glioblastoma; lung cancer; radiosensitizer; radiotherapy.

Improvement of the efficacy of radiotherapy for lung cancer and glioblastoma is urgently needed. We synthesized several novel DNA methyltransferase inhibitors and evaluated their potentials as possible radiosensitizers. Eleven non-nucleoside compounds were synthesized and evaluated along with one known compound using human lung cancer (A549) and glioblastoma (U373MG) cells. Cytotoxicity and radiosensitizing effects were evaluated using clonogenic assay. Sensitizer enhancement ratios at a survival fraction of 0.5 were calculated, and statistical anal. was performed using the ratio paired t-test. The inhibitory effects of three selected compounds on the activity of DNA methyltransferase 1 (DNMT1) and the pharmacokinetic profiles were analyzed. All twelve compounds demonstrated various levels of cytotoxicity. Of the twelve compounds, eleven and eight compounds radiosensitized A549 and U373MG cells, resp., with at least marginal significance (p<0.10). The sensitizer enhancement ratios in A549 and U373MG ranged 1.166-2.537 and 1.083-1.743 among compounds with radiosensitizing effects, resp. The three selected compounds inhibited DNMT1 activity by 26.5-78.5%. Elimination half-lives ranged from 0.3 to 1.3 h. Novel DNA methyltransferase inhibitors with significant radiosensitizing capacity and improved biostability were synthesized. These materials will serve as a basis for the development of novel radiosensitizers. Anticancer Research published new progress about Cytotoxicity. 142-90-5 belongs to class esters-buliding-blocks, name is Dodecyl 2-methylacrylate, and the molecular formula is C16H30O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lecholocholo, Nkamo published the artcileInfluence of different rootstocks on quality and volatile constituents of cantaloupe and honeydew melons (Cucumis melo. L) grown in high tunnels, SDS of cas: 140-11-4, the main research area is Cucumis rootstock volatile; Antioxidant activity; Chemometric approach; Cucumis melo; Grafting; Volatile compounds.

Two rootstock crosses of sweet melon and watermelon (Cucurbita moschata x Cucurbita maxima hybrids), ‘Kickstart’ and ‘Carnivor’, grafted onto four melon cultivars (cantaloups; ‘Majestic’, ‘Hunter’, ‘Honeygoal’ and ‘Honeyval’) were evaluated for quality, phytonutrient composition and volatile compounds in the 2020 and 2021 growing season at two harvests. Grafted fruits showed higher SSC/TA ratio, and antioxidant scavenging activity. Grafted ‘Majestic/Carnivor’ and ‘Honeyval/ Carnivor’ melons significantly increased the ascorbic acid content than the controls. ‘Majestic/Carnivor’ melons showed the highest β- carotene and lutein than the controls. PLS-DA score plots discriminated the grafted cantaloupes and honeydew melons from controls based on the concentration of volatile compounds Hexyl acetate and hexadecane resp. discriminated the grafted cantaloups and honeydew melons from ungrafted fruits. ‘Carnivor’ rootstocks showed higher expression of volatiles in the grafted cantaloupes and honeydew melons in the heat map. Panellists preferred Majestic/Carnivor’ and ‘Honeyval/ Carnivor’ melons.

Food Chemistry published new progress about Cucumis melo. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, SDS of cas: 140-11-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koh, Pei Chen published the artcileSensory quality and flavour of alginate coated and repetitive pulsed light treated fresh-cut cantaloupes (Cucumis melo L. Var. Reticulatus Cv. Glamour) during storage, Application of Methyl octanoate, the main research area is Cucumis alginate sensory quality repetitive pulsed light food storage; Alginate coating; Aroma; Flavour; Fresh-cut cantaloupes; Repetitive pulsed light; Sensory.

Fresh-cut fruits are popular due to the convenience provided. However, fresh-cut processes damage fruit tissues and reduce the shelf life of products. Pulsed light (PL) treatment is a decontamination method of foods. PL treatment given repetitively at a certain interval during storage could further extend the shelf life of fresh-cut fruits. Edible coating preserves fresh-cut fruits by providing mech. strength and reducing respiration and water loss. This study was to evaluate the effects of alginate coating combined with repetitive pulsed light (RPL) on sensory quality and flavor of fresh-cut cantaloupes during storage. Cantaloupes were treated with alginate (1.86%, w/v) and RPL (0.9 J/cm2 at every 48 h up to 26 days) alone or in combination. Flavor anal. of fresh-cut cantaloupes was carried out every 12 days during storage at 4 ± 1 °C while sensory anal. was performed on day 32. Alginate coating and/or RPL retained sugar contents (17.92-20.01 g/kg FW for fructose, 18.77-19.98 g/kg FW for glucose and 23.02-29.41 g/kg FW for sucrose) in fresh-cut cantaloupes during storage. Combination of alginate with RPL reduced accumulation of lactic acid although alginate coating was more effective to minimise changes of other organic acids in fresh-cut cantaloupes. The combined treatment was also more effective than individual treatment in retaining total aroma compound concentration of fresh-cut cantaloupes during storage with the highest relative concentration, i.e. 3.174 on day 36. Overall, the combined alginate coating and RPL was effective to maintain the fresh-like sensory quality of fresh-cut cantaloupes with insignificant overall acceptability compared to the control.

Journal of Food Science and Technology (New Delhi, India) published new progress about Cucumis melo. 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, Application of Methyl octanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kende, Aniko published the artcileHigh throughput quantitative volatile profiling of melons with silicone rod extraction – thermal desorption – GC-MS for plant breeding line selection, SDS of cas: 140-11-4, the main research area is volatile compound melon silicone rod extraction GC MS; Flavor profiling; GC–MS; Line selection; Marker assisted breeding; Melon; Plant breeding; Silicone rod extraction; Thermal desorption; Volatiles.

Volatile compounds determine the aroma of fruits, giving their unique flavor characteristics. The aim of many plant breeding projects is to improve the consumers’ flavor experience when eating fresh produce. Large scale breeding trials produce thousands of samples which need volatile profiling amongst other phenotypes. Despite this interest, current methods have limitations: sampling unsuitable for field conditions, high cost and the inherent issue of highly variable data, which can hinder interpretation. We introduced a simple and robust sampling methodol. based on silicone rod extraction, thermal desorption gas chromatog. – mass spectrometry (GC-MS) to address these issues. We used differentiated calibration standards to generate quant. data for metabolites of varying abundance. The method was used to profile 327 melons with high sensitivity (0.05-10 ng/mL, compound dependent), good reproducibility (7%) and differentiate melon varieties based on their volatile profile. The data were then used for line selection for a desired flavor profile.

Food Chemistry published new progress about Cucumis melo. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, SDS of cas: 140-11-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Farcuh, Macarena published the artcileSensory, physicochemical and volatile compound analysis of short and long shelf-life melon (Cucumis melo L.) genotypes at harvest and after postharvest storage, HPLC of Formula: 140-11-4, the main research area is sensory descriptive analysis Cucumis melo harvest postharvest storage; Cucumis melo L.; Flavor; Fruit quality; HS-SPME-GC–MS; Postharvest storage; Sensory descriptive analysis; Volatiles.

Flavor is a key attribute defining melon fruit quality and driving consumer preferences. We characterized and compared fruit ripening patterns (ethylene, respiration), physicochem. properties (rind/flesh color, firmness, soluble solids, acidity), aroma volatiles, and flavor-related sensory attributes in seven melon genotypes differing in shelf life capacity. Fruits were evaluated at optimal maturity and after storage for six days at 5°C plus one day at room temperature Total volatile content increased after storage in all genotypes, with esters being dominant. Shorter shelf-life genotypes, displaying a sharper climacteric phase, correlated with fruity/floral/sweet flavor-related descriptors, and with esters, sulfur-containing compounds and a terpenoid. Longer shelf-life types were associated with firmness, green and grassy aroma/flavor and aldehydes. Multivariate regression identified key volatiles that predict flavor sensory perception, which could accelerate breeding of longer shelf-life melons with improved flavor characteristics.

Food Chemistry: X published new progress about Cucumis melo. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, HPLC of Formula: 140-11-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gyorgy, Csilla published the artcileSynthesis and derivatization of epoxy-functional sterically-stabilized diblock copolymer spheres in non-polar media: does the spatial location of the epoxy groups matter, Recommanded Product: Dodecyl 2-methylacrylate, the main research area is epoxy functionalized sterically stabilized diblock copolymer sphere synthesis.

Epoxy-functional sterically-stabilized diblock copolymer spherical nanoparticles were synthesized via polymerization-induced self-assembly (PISA) in mineral oil. Epoxy groups were located either (i) in the nanoparticle cores or (ii) within the steric stabilizer chains. For the first system, RAFT dispersion polymerization of glycidyl methacrylate (GlyMA) was conducted using a poly(lauryl methacrylate) (PLMA63) precursor. The second system involved statistical copolymerization of GlyMA with lauryl methacrylate to produce a P(LMA50-stat-GlyMA9) precursor followed by chain extension using Me methacrylate (MMA). 1H NMR studies and THF GPC anal. indicated that high monomer conversions (â‰?95%) and narrow mol. weight distributions (Mw/Mn â‰?1.17) were obtained for both formulations. Dynamic light scattering indicated hydrodynamic diameters of 26 nm and 28 nm for P(LMA50-stat-GlyMA9)-PMMA67 and PLMA63-PGlyMA89 spheres, resp. Transmission electron microscopy studies confirmed a well-defined spherical morphol. in each case. Post-polymerization modification of these spherical nanoparticles was examined by reacting the epoxy groups with benzylamine. For the PLMA63-PGlyMA89 spheres, an [amine]/[epoxy] molar ratio of unity was sufficient to react all the epoxy groups. In contrast, the P(LMA50-stat-GlyMA9)-PMMA67 spheres required a fifty-fold excess of benzylamine for complete reaction. Furthermore, epoxy ring-opening reactions were conducted using either a trace amount of water or 50% volume/volume aqueous acetic acid at 110°C.

Polymer Chemistry published new progress about Crosslinking. 142-90-5 belongs to class esters-buliding-blocks, name is Dodecyl 2-methylacrylate, and the molecular formula is C16H30O2, Recommanded Product: Dodecyl 2-methylacrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xia, Shan published the artcileBioinspired Dynamic Cross-Linking Hydrogel Sensors with Skin-like Strain and Pressure Sensing Behaviors, Quality Control of 142-90-5, the main research area is hydrogel strain pressure sensor.

Biomimetic skin-like elec. materials have been rapidly developed for human-machine interfaces, health monitoring and soft robots. However, it is still a challenge of achieving a combination of the mech. and sensory properties like human skin. Here, a bioinspired phys. crosslinking hydrogel sensor is designed and fabricated based on an ionic conductive hydrogel with hybrid latex particles phys. crosslinked network. The hydrogels exhibit excellent mech. adaptability similar to human skin, including low modulus, excellent stretchability, robust elasticity, rapid self-recoverability and good antifatigue property. Moreover, the addition of LiCl gives hydrogel ideal ionic conducive behavior as high-performance wearable sensors. The hydrogel-based sensor exhibits high sensitivity (GF=5.44) at a broad strain window (0.25-2000%), excellent pressure sensing capability, rapid response time, negligible hysteresis and good durability. As a result, the hydrogel sensor can monitor various human motions, including large-scale joint bending, running and jumping, as well as tiny phonating and breathing. Therefore, the strategy will broaden the path for new generation of biomimetic sensors with skin-like mech. and strain and pressure sensing performances.

Chemistry of Materials published new progress about Crosslinking. 142-90-5 belongs to class esters-buliding-blocks, name is Dodecyl 2-methylacrylate, and the molecular formula is C16H30O2, Quality Control of 142-90-5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guan, Song published the artcileLiquid Crystalline Nanowires by Polymerization Induced Hierarchical Self-Assembly, Recommanded Product: Dodecyl 2-methylacrylate, the main research area is liquid crystalline nanowire polymerization hierarchical self assembly.

By taking advantage of strong liquid crystallization ordering and photo dimerization of the mesogen stilbene, we propose large-scale synthesis of nanowires of stilbene-containing block copolymers by polymerization induced hierarchical self-assembly. The interior of nanowires is in the type of liquid crystal (LC) structure with highly ordered smectic LC layers, which are perpendicular to the long axis. The alternative striped structure consists of the polymethacrylate backbone and stilbene-containing side chain. The approach is general toward stilbene-containing block copolymer LC nanowires, irrelevant with the composition of stabilizer blocks. The nanowires become robust with the layered structure preserved after crosslinking via dimerization upon UV irradiation The nanowires reported here may provide one-dimensional model blocks toward superstructures, which can be used in the fields of elec. nanoconductors, functional additives, etc.

Macromolecules (Washington, DC, United States) published new progress about Crosslinking. 142-90-5 belongs to class esters-buliding-blocks, name is Dodecyl 2-methylacrylate, and the molecular formula is C16H30O2, Recommanded Product: Dodecyl 2-methylacrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics