Month: December 2022

Facile Construction of Troponoid Derivatives Incorporating Imidazolin-2-one Moieties was written by Yu, Jing;Chen, Xiaobei;Liu, Ye;Wu, Bing;Li, Haiyan;Hu, Yanwei;Wang, Liang;Zhang, Shilei. And the article was included in Synthesis in 2020.Quality Control of 3-Cyanophenylisocyanate This article mentions the following:

Troponoid derivatives incorporating imidazolin-2-one moieties I [R = 4-Me, 3-F, 3-CF₃-4-Cl, etc.] were efficiently constructed via a cascade process, under simple thermal conditions, which features a novel nitrogen source, is catalyst- and oxidant-free and was high atom- and step-economy. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Quality Control of 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A systematic investigation of comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry with dynamic pressure gradient modulation for high peak capacity separations was written by Schoneich, Sonia;Trinklein, Timothy J.;Warren, Cable G.;Synovec, Robert E.. And the article was included in Analytica Chimica Acta in 2020.SDS of cas: 118-61-6 This article mentions the following:

Dynamic pressure gradient modulation (DPGM) in full modulation mode is optimized for comprehensive two-dimensional (2D) gas chromatog. (GC x GC) with time-of-fight mass spectrometry (TOFMS) detection to obtain high peak capacity separations and demonstrate broad applicability for complex samples. A pulse valve introduces an auxiliary carrier gas flow at a T-union connecting the first dimension (¹D) column to the second dimension (²D) column. At a sufficiently high auxiliary pressure (P_aux) the ¹D flow is temporarily stopped. Then, during each modulation period (P_M) the valve is turned off briefly, a period termed the pulse width (p_w), allowing the ¹D effluent to essentially be reinjected onto the ²D column for the modulated separations Modifications to the modulator assembly are provided to improve performance. Method optimization is demonstrated for a 116-component test mixture by tuning the P_aux and the p_w. For a P_M = 2 s and ¹F of 0.10 mL/min, the optimal p_w and initial P_aux selected were 200 ms and 330.9 kPa (33 psig), resp. The 30 min separation of the test mixture provided a ¹D peak capacity of ¹n_c = 330 and a ²D peak capacity of ²n_c = 15, hence an ideal 2D peak capacity n_c,2D = ¹n_c x ²n_c = 4950. Likewise, the 2D peak capacity corrected for undersampling of the ¹D separation was 4500 and corrected for both undersampling and sampling variation via statistical overlap theory was 4090. These results provide a 2-fold improvement in peak capacity relative to the previous DPGM study in full modulation mode for GC x GC-TOFMS. The optimized conditions were applied for a variety of applications: diesel fuel, derivatized cow serum, solid phase microextraction (SPME) of coffee headspace, and SPME of river water headspace. Addnl., the fraction of 2D separation space utilized (f_coverage), as defined by the min. convex hull method, ranged from 0.60 to 0.85. We observed that any f_coverage correction to 2D peak capacity is highly sample dependent, since all samples, except for the diesel sample, were run with the same separation conditions, and yet the f_coverage ranged from 0.60 to 0.80. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6SDS of cas: 118-61-6).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 118-61-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

11,12-Secoprostaglandins. 3. 8-Alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids and related compounds was written by Smith, Robert L.;Bicking, John B.;Gould, Norman P.;Lee, Ta-Jyh;Robb, Charles M.;Kuehl, Frederick A. Jr.;Mandel, Lewis R.;Cragoe, Edward J. Jr.. And the article was included in Journal of Medicinal Chemistry in 1977.Related Products of 62020-09-1 This article mentions the following:

Seven title compounds with structural features of 11,12-secoprostaglandins were prepared and tested for prostaglandin E mimicry in stimulating cyclic AMP [60-92-4] in the mouse ovary and in binding to the rat lipocyte prostaglandin receptor. The most active compound, 8-(methylsulfonyl)-12-hydroxyheptadecanoic acid (I) [59768-16-0], markedly stimulated cyclic AMP formation in the mouse ovary and human psoriatic skin slices, showed significant affinity for a prostaglandin receptor, and effectively inhibited antigen-induced lymphocyte transformation. I is not a substrate for 15-hydroxyprostaglandin dehydrogenase and is not a phosphodiesterase inhibitor. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, Methyl 2-(methylsulfonyl)acetate (cas: 62020-09-1Related Products of 62020-09-1).

Methyl 2-(methylsulfonyl)acetate (cas: 62020-09-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 62020-09-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Non-Arrhenius behavior: Influence of antioxidants on lifetime predictions for materials used in the cable and wire industries was written by Blivet, Camille;Larche, Jean-Francois;Israeli, Yael;Bussiere, Pierre-Olivier. And the article was included in Polymer Degradation and Stability in 2022.Product Details of 6683-19-8 This article mentions the following:

Thermo-oxidation (70-160°) of peroxide crosslinked polyethylene (XLPE) formulations stabilized with different antioxidants were studied. In order to sep. study the influence of three commonly used antioxidants, three formulations were prepared with only one antioxidant each (0.3% weight/weight): a sterically hindered phenolic antioxidant (Irganox 1010), an organosulfur antioxidant (Hostanox SE4) and an oligomeric, sterically hindered amine light stabilizer (HALS 94). The materials were characterized by IR spectroscopy measurements and tensile testing. Results proved that the addition of antioxidants causes in each case an Arrhenius break, occurring at a different temperature depending on the nature of the added antioxidant. Interestingly, the study of the thermo-oxidation (50-105°) of a certified antioxidant-free polyethylene (non-cross-linked) revealed no Arrhenius deviation. In a previous paper, the authors reported an Arrhenius deviation at low temperature (50°) for two crosslinked PE and EPR, containing residual process antioxidants. These results strengthen our hypothesis that several Arrhenius deviations could be explained by the presence of antioxidants (residual process antioxidants or formulation antioxidants), which “activity” is extremely dependent on the temperature In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Product Details of 6683-19-8).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 6683-19-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Encapsulation of Zanthoxylum bungeanum essential oil to enhance flavor stability and inhibit lipid oxidation of C hinese-style sausage was written by Meng, Fan-Bing;Lei, Yu-Ting;Zhang, Qian;Li, Yun-Cheng;Chen, Wei-Jun;Liu, Da-Yu. And the article was included in Journal of the Science of Food and Agriculture in 2022.COA of Formula: C12H20O2 This article mentions the following:

Zanthoxylum bungeanum essential oil (ZBEO) is a popular seasoning, commonly used in the food industry. It contains many easily degraded and highly volatile bioactive substances. Control of the stability of the bioactive substances in ZBEO is therefore very important in the food industry. In this study, microencapsulation was applied to improve ZBEO stability. The key parameters for microcapsule preparation were optimized by the Box-Behnken design method, and the optimum conditions were as follows: ratio of core to wall, 1:8; ratio of hydroxypropyl-α-cyclodextrin (HPCD) to soy protein isolate (SPI), 4; total solids content, 12%; and homogenization speed, 12 000 rpm. Antioxidant experiments have indicated that tea polyphenols (TPPs) effectively inhibited hydroxy-α-sanshool degradation in ZBEO microcapsules. Application of ZBEO microcapsules in Chinese-style sausage effectively inhibited lipid oxidation in sausages and protected hydroxy-α-sanshool and typical volatiles from volatilization and degradation during sausage storage. The results suggested that ZBEO microencapsulation is an effective strategy for improving the stability of its bioactive components and flavor ingredients during food processing. 2022 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3COA of Formula: C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C12H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Development of small-molecule inhibitors of fatty acyl-AMP and fatty acyl-CoA ligases in Mycobacterium tuberculosis was written by Baran, Marzena;Grimes, Kimberly D.;Sibbald, Paul A.;Fu, Peng;Boshoff, Helena I. M.;Wilson, Daniel J.;Aldrich, Courtney C.. And the article was included in European Journal of Medicinal Chemistry in 2020.Application In Synthesis of 12-Methoxy-12-oxododecanoic acid This article mentions the following:

Lipid metabolism in Mycobacterium tuberculosis (Mtb) relies on 34 fatty acid adenylating enzymes (FadDs) that can be grouped into two classes: fatty acyl-CoA ligases (FACLs) involved in lipid and cholesterol catabolism and long chain fatty acyl-AMP ligases (FAALs) involved in biosynthesis of the numerous essential and virulence-conferring lipids found in Mtb. The precise biochem. roles of many FACLs remain poorly characterized while the functionally non-redundant FAALs are much better understood. Here we describe the systematic investigation of 5′-O-[N-(alkanoyl)sulfamoyl]adenosine (alkanoyl adenosine monosulfamate, alkanoyl-AMS) analogs as potential multitarget FadD inhibitors for their antitubercular activity and biochem. selectivity towards representative FAAL and FACL enzymes. We identified several potent compounds including 12-azidododecanoyl-AMS, 11-phenoxyundecanoyl-AMS, and nonyloxyacetyl-AMS with min. inhibitory concentrations (MICs) against M. tuberculosis ranging from 0.098 to 3.13μM. Compound I was notable for its impressive biochem. selectivity against FAAL28 (apparent K_i = 0.7μM) vs. FACL19 (K_i > 100μM), and uniform activity against a panel of multidrug and extensively drug-resistant TB strains with MICs ranging from 3.13 to 12.5μM in minimal (GAST) and rich (7H9) media. The SAR anal. provided valuable insights for further optimization of I and also identified limitations to overcome. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Application In Synthesis of 12-Methoxy-12-oxododecanoic acid).

12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of 12-Methoxy-12-oxododecanoic acid

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and evaluation of novel imidazo[4,5-c]pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis was written by Madaiah, Malavalli;Prashanth, Maralekere K.;Revanasiddappa, Hosakere D.;Veeresh, Bantal. And the article was included in New Journal of Chemistry in 2016.Related Products of 16413-26-6 This article mentions the following:

The current study involves the synthesis of novel imidazo[4,5-c]pyridine derivatives (IPD) containing amide/urea/sulfonamide. The synthesized compounds were evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. The pharmacol. activities were determined by the objective to better understand their structure-activity relationship (SAR) for their in vitro antimycobacterial activity against M. tuberculosis. Some synthesized compounds showed significant activity against M. tuberculosis based on the agar dilution method. Among the forty-one compounds screened, compounds 21, 22 and 23 were found to be the most active compounds against M. tuberculosis. In the in vivo animal model, 21, 22 and 23 decreased the bacterial load in lung and spleen tissues at the dose of 50 mg kg^-1 body weight In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Related Products of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors was written by Vats, Lalit;Sharma, Vikas;Angeli, Andrea;Kumar, Rajiv;Supuran, Claudiu T.;Sharma, Pawan K.. And the article was included in European Journal of Medicinal Chemistry in 2018.Recommanded Product: 13669-10-8 This article mentions the following:

The design, synthesis and biol. evaluation of a library of 1,2,3-triazole carboxylates incorporating carboxylic acid, hydroxymethyl, carboxylic acid hydrazide, carboxamide and benzenesulfonamide moieties was disclosed. All the compounds were investigated for their inhibition potential against carbonic anhydrase (CA, EC 4.2.1.1) human (h) isoforms hCA 1, 2, 4 and 9, well established drug targets. The cytosolic isoform hCA 1 was inhibited with Ki’s ranging between 53.2 nM and 7.616 μM whereas the glaucoma associated cytosolic isoform hCA 2 was inhibited with Ki’s in the range 21.8 nM-0.807 μM. The membrane bound isoform hCA 4, involved in glaucoma and retinitis pigmentosa among others, was effectively inhibited by some of these compounds with Ki < 60 nM, better than the reference drug acetazolamide (AAZ). The tumor associated isoform hCA 9, a recently validated antitumor/antimetastatic drug target, was also effectively inhibited by some of the new sulfonamides, which possessed the potential to be used as tools for exploring in more details the selective inhibition of hCAs involved in various pathologies. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hazardous compounds in recreational and urban recycled surfaces made from crumb rubber. Compliance with current regulation and future perspectives was written by Celeiro, Maria;Armada, Daniel;Dagnac, Thierry;de Boer, Jacob;Llompart, Maria. And the article was included in Science of the Total Environment in 2021.Electric Literature of C20H26O4 This article mentions the following:

Crumb rubber obtained from scrap tires is greatly employed for the construction of different facilities for sport, recreational and other uses. However, in recent years the concern about their safety and the related adult and children exposure to these surfaces is growing. This study aims a thorough chem. characterization encompassing 42 hazardous compounds, including polycyclic aromatic hydrocarbons (PAHs), phthalates, adipates, antioxidants and vulcanization agents in a wide range of crumb rubber from different surfaces. For the extraction of the target compounds, a method based on ultrasound-assisted extraction followed by gas chromatog.-tandem mass spectrometry (UAE-GC-MS/MS) was validated. Forty crumb rubber samples coming from synthetic turf football pitches, outdoor and indoor playgrounds, urban pavements, com. tiles and granulates, and scrap tires, were analyzed. In addition, green alternative materials, such as sand and artificial turf based on cork granulate infill were included to compare the levels of the target compounds with those of crumb rubber. Most of the analyzed recycled surfaces meet the recent limits proposed by the European Commission for rubber granulates and mulches, although they exceed in several cases the maximum levels allowed for rubber consumer products. Besides, most of the other target compounds, including several of them considered as endocrine disruptors, were detected in the analyzed samples, reaching ppm concentrations In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Electric Literature of C20H26O4).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C20H26O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hydroxamic Acids as Potent Inhibitors of Endothelin-Converting Enzyme from Human Bronchiolar Smooth Muscle was written by Bihovsky, Ron;Levinson, Barry L.;Loewi, Rivka C.;Erhardt, Paul W.;Polokoff, Mark A.. And the article was included in Journal of Medicinal Chemistry in 1995.COA of Formula: C11H20O4 This article mentions the following:

Hydroxamic acids HONHCOCHRCO-X-R¹ (I; R = H. CHMe₂, CH₂CHMe₂; X = β-Ala, Asn, Trp, Gly; R¹ = OH. NH₂), derived from malonyl amino acids, and HONHCHCH₂CH(CHMe₂)CO-X-R¹ (X = Asn, β-Ala, Trp, R¹ = OH, NH₂), derived from succinyl amino acids, were synthesized as inhibitors of human bronchiolar smooth muscle endothelin-converting enzyme (HBSM ECE). Several unexpected side reactions were discovered, particularly in the synthesis of hydroxamates derived from succinates. In vitro evaluation against human bronchiolar ECE revealed that in all cases hydroxamates derived from malonate were more potent than hydroxamates derived from succinate. P₁‘ side chains R = CHMe₂, CH₂CHMe₂ were suitable; omission of the P₁‘ side chain (R = H) seriously diminished potency. In the P₂‘ position, several amino acids gave potent malonate-derived hydroxamate inhibitors (IC₅₀ = 0.2-6.8 nM), and I (R = CHMe₂, X = β-Ala, R¹ = OH) (II) provided an extremely potent inhibitor (IC₅₀ = 0.01 nM). C-terminus carboxylates are much more potent ECE inhibitors than the corresponding amides. Most of the hydroxamates were also potent inhibitors of thermolysin and neutral endopeptidase (NEP); however, the P₂‘ β-Ala derivative II uniquely inhibited HBSM ECE much more potently than NEP. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4COA of Formula: C11H20O4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C11H20O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics