Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials was written by Snyder, Lawrence B.;Meng, Zhaoxing;Mate, Robert;D’Andrea, Stanley V.;Marinier, Anne;Quesnelle, Claude A.;Gill, Patrice;DenBleyker, Kenneth L.;Fung-Tomc, Joan C.;Frosco, MaryBeth;Martel, Alain;Barrett, John F.;Bronson, Joanne J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.HPLC of Formula: 2327-45-9 This article mentions the following:
A series of potential antimicrobial derivatives possessing bioisosteric replacements for the central oxazolidinone ring found in oxazolidinone antibacterials have been prepared The design concept involved replacement of the requisite sp3-hybridized stereogenic center found at the 5-position of the oxazolidinone with a nitrogen atom. The synthesis and antibacterial activity of three such ring systems, the benzisoxazolinones, e.g., I, pyrroles, e.g., II, and isoxazolinones, e.g., III, is described. In the experiment, the researchers used many compounds, for example, Methyl 5-methoxy-2-nitrobenzoate (cas: 2327-45-9HPLC of Formula: 2327-45-9).
Methyl 5-methoxy-2-nitrobenzoate (cas: 2327-45-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 2327-45-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics