Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors was written by Pan, Xiaoyan;Dong, Jinyun;Gao, Hongping;Wang, Fang;Zhang, Yanmin;Wang, Sicen;Zhang, Jie. And the article was included in Chemical Biology & Drug Design in 2014.Safety of Ethyl 3-amino-4-methylbenzoate This article mentions the following:
A series of pyridin-3-yl pyrimidines was synthesized and evaluated for their Bcr-Abl inhibitory and anticancer activity. The preliminary results indicated that some compounds were promising anticancer agents. Compounds I [R = 3-CF3, 3,5-(CF3)2, 3-Br-5-CF3] exhibited potent Bcr-Abl inhibitory activity, suggesting that aniline containing halogen substituents might be important for biol. activity. Mol. docking was carried out to investigate the binding mode of them with Bcr-Abl. Details of synthesis and SAR studies of these compounds are described. In the experiment, the researchers used many compounds, for example, Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8Safety of Ethyl 3-amino-4-methylbenzoate).
Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Safety of Ethyl 3-amino-4-methylbenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics