Hit to Lead Account of the Discovery of Bisbenzamide and Related Ureidobenzamide Inhibitors of Rho Kinase was written by Morwick, Tina;Buttner, Frank H.;Cywin, Charles L.;Dahmann, Georg;Hickey, Eugene;Jakes, Scott;Kaplita, Paul;Kashem, Mohammed A.;Kerr, Steven;Kugler, Stanley;Mao, Wang;Marshall, Daniel;Paw, Zofia;Shih, Cheng-Kon;Wu, Frank;Young, Erick. And the article was included in Journal of Medicinal Chemistry in 2010.Category: esters-buliding-blocks This article mentions the following:
A highly selective series of bisbenzamide inhibitors of Rho-associated coiled-coil forming protein kinase (ROCK) and a related ureidobenzamide series, both identified by high throughput screening (HTS), are described. Details of the hit validation and lead generation process, including structure-activity relationship (SAR) studies, a selectivity assessment, target-independent profiling (TIP) results, and an anal. of functional activity using a rat aortic ring assay are discussed. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Category: esters-buliding-blocks).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics