Straightforward Enantioselective Access to γ-Butyrolactones Bearing an All-Carbon β-Quaternary Stereocenter was written by Meninno, Sara;Fuoco, Tiziana;Tedesco, Consiglia;Lattanzi, Alessandra. And the article was included in Organic Letters in 2014.Application of 33166-79-9 This article mentions the following:
An enantioselective one-pot aldol/lactonization sequence has been developed to access highly challenging γ-butyrolactones bearing an all-carbon quaternary stereocenter at the β-position by reacting acylated succinic esters with aqueous formaldehyde in the presence of 3 mol % loading of a cinchona alkaloid-derived squaramide providing direct access to paraconic acid derivatives in high yield and fairly good level of enantioselectivity (up to 88% ee). Thus, e.g., keto diester I (R1 = 2-phenyl-2-Pr, R3 = Me) + paraformaldehyde in presence of epi-hydroquinine-derived squaramide afforded lactone II in 79% yield and 78% ee. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Application of 33166-79-9).
Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 33166-79-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics