Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis was written by Guo, Tao;Shao, Yuefei;Qian, Gang;Rokosz, Laura L.;Stauffer, Tara M.;Hunter, Rachael C.;Babu, Suresh D.;Gu, Huizhong;Hobbs, Doug W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Application In Synthesis of 3-Cyanophenylisocyanate This article mentions the following:
An encoded combinatorial library based on aryl- and biarylpiperidine scaffolds was designed and synthesized. Screening of this library resulted in the discovery of high-nanomolar biarylpiperidine-based MCH1 receptor antagonists. Follow-up optimization using a parallel synthesis provided potent, single digit nanomolar antagonists. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Application In Synthesis of 3-Cyanophenylisocyanate).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of 3-Cyanophenylisocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics