Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A was written by Guichou, Jean-Francois;Viaud, Julien;Mettling, Clement;Subra, Guy;Lin, Yea-Lih;Chavanieu, Alain. And the article was included in Journal of Medicinal Chemistry in 2006.HPLC of Formula: 16413-26-6 This article mentions the following:
Cyclophilin A is involved in many cellular processes, including protein folding and intracellular transports. Because cyclophilin A has been shown to interact with HIV-1 gag proteins and to enhance the viral infectivity, nonimmunosuppressive cyclophilin A ligands may represent a new class of therapeutic agents against HIV. In this paper, a virtual screening using structure- and pharmacophore-based design to identify original nonpeptidic cyclophilin ligands is reported. Following a lead identification of compounds 1-(3-benzyloxypyridin-2-yl)-3-(3-chlorophenyl)urea [I; R1 = H, R2 = Cl (II)] and 1-(3-benzyloxypyridin-2-yl)-3-(3-trifluoromethylphenyl)urea [I; R1 = H, R2 = CF3 (III)] (IC50 = 0.3 μM), a series of mols. were synthesized from a diarylurea scaffold and evaluated for their in vitro ability to inhibit the cis-trans isomerase activity of cyclophilin A. Mol. modifications provided several more potent compounds, in particular analogs I (R1 = NO2, R2 = H) and I (R1 = CO2Et, R2 = H) with IC50 of 14 and 20 nM, resp. Then, the effect of analogs II and III (R1 = H, R2 = CF3) on HIV virion infectivity in both immortalized and primary cells was evaluated. Both II and III reduced virion infectivity in the replication-defective one-round infection assay, but only II impaired wild-type HIV infection in human peripheral blood mononuclear cells. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6HPLC of Formula: 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 16413-26-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics