Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases was written by Goetz, Marion G.;Caffrey, Conor R.;Hansell, Elizabeth;McKerrow, James H.;Powers, James C.. And the article was included in Bioorganic & Medicinal Chemistry in 2004.Application of 87694-53-9 This article mentions the following:
A new series of peptidyl allyl sulfone inhibitors was discovered while trying to synthesize epoxy sulfone inhibitors from vinyl sulfones using basic oxidizing conditions. The various dipeptidyl allyl sulfones were evaluated with calpain I, papain, cathepsins B and L, cruzain and rhodesain and found to be potent inhibitors. In comparison to the previously developed class of vinyl sulfone inhibitors, the novel dipeptidyl allyl sulfones were more potent inhibitors than the corresponding dipeptidyl vinyl sulfones. It was observed that the stereochem. of the vinyl sulfone precursor played a role in the potency of the dipeptidyl allyl sulfone inhibitor. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Application of 87694-53-9).
(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 87694-53-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics