Minor groove DNA binders as antimicrobial agents. 1. Pyrrole tetraamides are potent antibacterials against vancomycin resistant enterococci and methicillin resistant Staphylococcus aureus was written by Dyatkina, Natalia B.;Roberts, Christopher D.;Keicher, Jesse D.;Dai, Yuqin;Nadherny, Joshua P.;Zhang, Wentao;Schmitz, Uli;Kongpachith, Ana;Fung, Kevin;Novikov, Alexander A.;Lou, Lillian;Velligan, Mark;Khorlin, Alexander A.;Chen, Ming S.. And the article was included in Journal of Medicinal Chemistry in 2002.COA of Formula: C7H8N2O4 This article mentions the following:
A new series of short pyrrole tetraamides are described whose submicromolar DNA binding affinity is an essential component for their strong antibacterial activity. This class of compounds is related to the linked bis-netropsins and bis-distamycins, but here, only one amino-pyrrole-carboxamide unit and an amidine tail is connected to either side of a central dicarboxylic acid linker. The highest degree of DNA binding, measured by compound-induced changes in UV melting temperatures of an AT-rich DNA oligomer, was observed for flat, aromatic linkers with no inherent bent, i.e., terephthalic acid or 1,4-pyridine-dicarboxylic acid. However, the antibacterial activity is critically linked to the size of the N-alkyl substituent of the pyrrole unit. None of the tetraamides with the commonly used methyl-pyrrole showed antibacterial activity. Isoamyl- or cyclopropylmethylene-substituted dipyrrole derivatives have the min. inhibitory concentrations in the submicromolar range. In vitro toxicity against human T-cells was studied for all compounds The degree to which compounds inhibited cell growth was neither directly correlated to DNA binding affinity nor directly correlated to antibacterial activity but seemed to depend strongly on the nature of the N-alkyl pyrrole substituents. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7COA of Formula: C7H8N2O4).
Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.COA of Formula: C7H8N2O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics